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| Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. |
| Grebien F, Vedadi M, Getlik M, Giambruno R, Grover A, Avellino R, Skucha A, Vittori S, Kuznetsova E, Smil D, Barsyte-Lovejoy D, Li F, Poda G, Schapira M, Wu H, Dong A, Senisterra G, Stukalov A, Huber KV, Schönegger A, Marcellus R, Bilban M, Bock C, Brown PJ, Zuber J, Bennett KL, Al-Awar R, Delwel R, Nerlov C, Arrowsmith CH, Superti-Furga G |
| Nature chemical biology. 2015 Jul 13. pii: nchembio.1859. doi: 10.1038/nchembio.1859. pmc: PMC4511833. mid: EMS63643 |
| PMID: 26167872 |
| KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth. |
| Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, Ciechanover A |
| Cell. 2015 Apr 11. pii: S0092-8674(15)00254-8. doi: 10.1016/j.cell.2015.03.001 |
| PMID: 25860612 |
| Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. |
| Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A, Jemth AS, Göktürk C, Sanjiv K, Strömberg K, Pham T, Berglund UW, Colinge J, Bennett KL, Loizou JI, Helleday T, Knapp S, Superti-Furga G |
| Nature. 2014 Apr 2. pii: nature13194. doi: 10.1038/nature13194. pmc: PMC4150021. mid: EMS57294 |
| PMID: 24695225 |
| A chemical biology approach identifies AMPK as a modulator of melanoma oncogene MITF. |
| Borgdorff V, Rix U, Winter GE, Gridling M, Müller AC, Breitwieser FP, Wagner C, Colinge J, Bennett KL, Superti-Furga G, Wagner SN |
| Oncogene. 2013 Jun 3. pii: onc2013185. doi: 10.1038/onc.2013.185 |
| PMID: 23728343 |
| KIT-D816V-independent oncogenic signaling in neoplastic cells in systemic mastocytosis: role of Lyn and Btk activation and disruption by dasatinib and bosutinib. |
| Gleixner KV, Mayerhofer M, Cerny-Reiterer S, Hörmann G, Rix U, Bennett KL, Hadzijusufovic E, Meyer RA, Pickl WF, Gotlib J, Horny HP, Reiter A, Mitterbauer-Hohendanner G, Superti-Furga G, Valent P |
| Blood. 2011 Jun 16. pii: blood-2010-06-289959. doi: 10.1182/blood-2010-06-289959 |
| PMID: 21680801 |
| Immunosuppression and atypical infections in CML patients treated with dasatinib at 140 mg daily. |
| Sillaber C, Herrmann H, Bennett K, Rix U, Baumgartner C, Böhm A, Herndlhofer S, Tschachler E, Superti-Furga G, Jäger U, Valent P |
| European journal of clinical investigation. 2009 Sep 9. pii: ECI2206. doi: 10.1111/j.1365-2362.2009.02206.x |
| PMID: 19744184 |
| Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. |
| Baumgartner C, Gleixner KV, Peter B, Ferenc V, Gruze A, Remsing Rix LL, Bennett KL, Samorapoompichit P, Lee FY, Pickl WF, Esterbauer H, Sillaber C, Superti-Furga G, Valent P |
| Experimental hematology. 2008 Jul 10. pii: S0301-472X(08)00206-3. doi: 10.1016/j.exphem.2008.04.017 |
| PMID: 18619723 |
| The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. |
| Kneidinger M, Schmidt U, Rix U, Gleixner KV, Vales A, Baumgartner C, Lupinek C, Weghofer M, Bennett KL, Herrmann H, Schebesta A, Thomas WR, Vrtala S, Valenta R, Lee FY, Ellmeier W, Superti-Furga G, Valent P |
| Blood. 2008 Jan 7. pii: blood-2007-08-104372. doi: 10.1182/blood-2007-08-104372 |
| PMID: 18180381 |
| Selective serotonin reuptake inhibitors--a new modality for the treatment of lymphoma/leukaemia? |
| Schuster C, Fernbach N, Rix U, Superti-Furga G, Holy M, Freissmuth M, Sitte HH, Sexl V |
| Biochemical pharmacology. 2007 Jul 20. pii: S0006-2952(07)00470-4. doi: 10.1016/j.bcp.2007.07.017 |
| PMID: 17709099 |
| Germline RBBP6 mutations in familial myeloproliferative neoplasms. |
| Harutyunyan AS, Giambruno R, Krendl C, Stukalov A, Klampfl T, Berg T, Chen D, Milosevic Feenstra JD, Jäger R, Gisslinger B, Gisslinger H, Rumi E, Passamonti F, Pietra D, Müller AC, Parapatics K, Breitwieser FP, Herrmann R, Colinge J, Bennett KL, Superti-Furga G, Cazzola M, Hammond E, Kralovics R |
| Blood. 2015 Nov 16. pii: blood-2015-09-668673. doi: 10.1182/blood-2015-09-668673 |
| PMID: 26574608 |
| Gene essentiality and synthetic lethality in haploid human cells. |
| Blomen VA, Májek P, Jae LT, Bigenzahn JW, Nieuwenhuis J, Staring J, Sacco R, van Diemen FR, Olk N, Stukalov A, Marceau C, Janssen H, Carette JE, Bennett KL, Colinge J, Superti-Furga G, Brummelkamp TR |
| Science (New York, N.Y.). 2015 Oct 15. pii: science.aac7557. doi: 10.1126/science.aac7557 |
| PMID: 26472760 |
| SLC38A9: a lysosomal amino acid transporter at the core of the amino acid-sensing machinery that controls MTORC1. |
| Rebsamen M, Superti-Furga G |
| Autophagy. 2015 Oct 2. doi: 10.1080/15548627.2015.1091143 |
| PMID: 26431368 |
| Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth. |
| Peter B, Winter GE, Blatt K, Bennett KL, Stefanzl G, Rix U, Eisenwort G, Hadzijusufovic E, Gridling M, Dutreix C, Hoermann G, Schwaab J, Radia D, Roesel J, Manley PW, Reiter A, Superti-Furga G, Valent P |
| Leukemia. 2015 Sep 9. pii: leu2015242. doi: 10.1038/leu.2015.242 |
| PMID: 26349526 |
| Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death. |
| Dixon SJ, Winter GE, Musavi LS, Lee ED, Snijder B, Rebsamen M, Superti-Furga G, Stockwell BR |
| ACS chemical biology. 2015 May 15. doi: 10.1021/acschembio.5b00245. pmc: PMC4509420 |
| PMID: 25965523 |
| Overcoming MITF-conferred drug resistance through dual AURKA/MAPK targeting in human melanoma cells. |
| Pathria G, Garg B, Borgdorff V, Garg K, Wagner C, Superti-Furga G, Wagner SN |
| Cell death & disease. 2016 Mar 10. pii: cddis2015369. doi: 10.1038/cddis.2015.369 |
| PMID: 26962685 |
| NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors. |
| Byrgazov K, Gorna M, Hoermann G, Koenig M, Ulreich R, Benesch M, Strenger V, Lackner H, Schwinger W, Sovinz P, Haas OA, van den Heuvel-Eibrink M, Niemeyer CM, Hantschel O, Valent P, Superti-Furga G, Urban C, Dworzak MN, Lion T |
| Leukemia. 2016 Aug 30. pii: leu2016250. doi: 10.1038/leu.2016.250 |
| PMID: 27573554 |
| Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities. |
| Radic-Sarikas B, Tsafou KP, Emdal KB, Papamarkou T, Huber KV, Mutz C, Toretsky JA, Bennett KL, Olsen JV, Brunak S, Kovar H, Superti-Furga G |
| Molecular cancer therapeutics. 2016 Nov 15. pii: 1535-7163.MCT-16-0235. doi: 10.1158/1535-7163.MCT-16-0235 |
| PMID: 28062706 |
| Next generation of network medicine: interdisciplinary signaling approaches. |
| Korcsmaros T, Schneider MV, Superti-Furga G |
| Integrative biology : quantitative biosciences from nano to macro. 2017 Jan 20. doi: 10.1039/c6ib00215c |
| PMID: 28106223 |
| TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML. |
| Valent P, Herndlhofer S, Schneeweiß M, Boidol B, Ringler A, Kubicek S, Gleixner KV, Hoermann G, Hadzijusufovic E, Müllauer L, Sperr WR, Superti-Furga G, Mannhalter C |
| Oncotarget. 2017 Apr 18. pii: 15481. doi: 10.18632/oncotarget.15481. pmc: PMC5410285 |
| PMID: 28416739 |
| Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter. |
| Radic-Sarikas B, Halasz M, Huber KVM, Winter GE, Tsafou KP, Papamarkou T, Brunak S, Kolch W, Superti-Furga G |
| Scientific reports. 2017 Jun 8. doi: 10.1038/s41598-017-03129-6. pii: 10.1038/s41598-017-03129-6 |
| PMID: 28596528 |
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