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| Cancers. 2022 Apr 26. pii: cancers14092163. doi: 10.3390/cancers14092163 |
| 7T HR FID-MRSI Compared to Amino Acid PET: Glutamine and Glycine as Promising Biomarkers in Brain Tumors. |
| Hangel G1, Lazen P2, Sharma S3, Hristoska B4, Cadrien C5, Furtner J6, Rausch I7, Lipka A8, Niess E9, Hingerl L10, Motyka S11, Gruber S12, Strasser B13, Kiesel B14, Preusser M15, Roetzer-Pejrimovsky T16, Wöhrer A17, Bogner W18, Widhalm G19, Rössler K20, Traub-Weidinger T21, Trattnig S22 |
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Abstract (1) Background: Recent developments in 7T magnetic resonance spectroscopic imaging (MRSI) made the acquisition of high-resolution metabolic images in clinically feasible measurement times possible. The amino acids glutamine (Gln) and glycine (Gly) were identified as potential neuro-oncological markers of importance. For the first time, we compared 7T MRSI to amino acid PET in a cohort of glioma patients. (2) Methods: In 24 patients, we co-registered 7T MRSI and routine PET and compared hotspot volumes of interest (VOI). We evaluated dice similarity coefficients (DSC), volume, center of intensity distance (CoI), median and threshold values for VOIs of PET and ratios of total choline (tCho), Gln, Gly, myo-inositol (Ins) to total N-acetylaspartate (tNAA) or total creatine (tCr). (3) Results: We found that Gln and Gly ratios generally resulted in a higher correspondence to PET than tCho. Using cutoffs of 1.6-times median values of a control region, DSCs to PET were 0.53 ± 0.36 for tCho/tNAA, 0.66 ± 0.40 for Gln/tNAA, 0.57 ± 0.36 for Gly/tNAA, and 0.38 ± 0.31 for Ins/tNAA. (4) Conclusions: Our 7T MRSI data corresponded better to PET than previous studies at lower fields. Our results for Gln and Gly highlight the importance of future research (e.g., using Gln PET tracers) into the role of both amino acids. |
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KEYWORDS: 7T, MR spectroscopy, MRSI, PET, choline, gliomas, glutamine, glycine |
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Publikations ID: 35565293 Quelle: öffnen |
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