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| ERJ open research. 2021 Dec 6. doi: 10.1183/23120541.00457-2021. pii: 00457-2021. pmc: PMC8646001 |
| Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study. |
| Wang G1, Hallberg J2, Charalampopoulos D3, Sanahuja MC4, Breyer-Kohansal R5, Langhammer A6, Granell R7, Vonk JM8, Mian A9, Olvera N10, Laustsen LM11, Rönmark E12, Abellan A13, Agusti A14, Arshad SH15, Bergström A16, Boezen HM17, Breyer MK18, Burghuber O19, Bolund AC20, Custovic A21, Devereux G22, Donaldson GC23, Duijts L24, Esplugues A25, Faner R26, Ballester F27, Garcia-Aymerich J28, Gehring U29, Haider S30, Hartl S31, Backman H32, Holloway JW33, Koppelman GH34, Lertxundi A35, Holmen TL36, Lowe L37, Mensink-Bout SM38, Murray CS39, Roberts G40, Hedman L41, Schlünssen V42, Sigsgaard T43, Simpson A44, Sunyer J45, Torrent M46, Turner S47, Van den Berge M48, Vermeulen RCH49, Vikjord SAA50, Wedzicha JA51, Maitland van der Zee AH52, Melén E53 |
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Abstract BACKGROUND: The prevalences of obstructive and restrictive spirometric phenotypes, and their relation to early-life risk factors from childhood to young adulthood remain poorly understood. The aim was to explore these phenotypes and associations with well-known respiratory risk factors across ages and populations in European cohorts.
METHODS: We studied 49 334 participants from 14 population-based cohorts in different age groups (≤10, >10-15, >15-20, >20-25 years, and overall, 5-25 years). The obstructive phenotype was defined as forced expiratory volume in 1 s (FEV)/forced vital capacity (FVC) z-score less than the lower limit of normal (LLN), whereas the restrictive phenotype was defined as FEV/FVC z-score ≥LLN, and FVC z-score
RESULTS: The prevalence of obstructive and restrictive phenotypes varied from 3.2-10.9% and 1.8-7.7%, respectively, without clear age trends. A diagnosis of asthma (adjusted odds ratio (aOR=2.55, 95% CI 2.14-3.04), preterm birth (aOR=1.84, 1.27-2.66), maternal smoking during pregnancy (aOR=1.16, 95% CI 1.01-1.35) and family history of asthma (aOR=1.44, 95% CI 1.25-1.66) were associated with a higher prevalence of obstructive, but not restrictive, phenotype across ages (5-25 years). A higher current body mass index (BMI was more often observed in those with the obstructive phenotype but less in those with the restrictive phenotype (aOR=1.05, 95% CI 1.03-1.06 and aOR=0.81, 95% CI 0.78-0.85, per kg·m increase in BMI, respectively). Current smoking was associated with the obstructive phenotype in participants older than 10 years (aOR=1.24, 95% CI 1.05-1.46).
CONCLUSION: Obstructive and restrictive phenotypes were found to be relatively prevalent during childhood, which supports the early origins concept. Several well-known respiratory risk factors were associated with the obstructive phenotype, whereas only low BMI was associated with the restrictive phenotype, suggesting different underlying pathobiology of these two phenotypes.
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Copyright ©The authors 2021. |
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Publikations ID: 34881328 Quelle: öffnen |
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