1Department of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131 Napoli, Italy. 2Medical University of Vienna, Center for Physiology and Pharmacology, Schwsrzspanierstr. 17, 1090 Vienna, Austria. 3Integrated Drug Discovery, Sanofi R&D, Waltham, Massachusetts 02451, United States. 4Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198, United States.