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| Expert review of endocrinology & metabolism. 2014 Sep 18. doi: 10.1586/17446651.2014.960845 |
| Selenium status in patients with autoimmune and non-autoimmune thyroid diseases from four European countries. |
| Krassas GE1, Pontikides N2, Tziomalos K3, Tzotzas T4, Zosin I5, Vlad M6, Luger A7, Gessl A8, Marculescu R9, Toscano V10, Morgante S11, Papini E12, Pirags V13, Konrade I14, Hybsier S15, Hofmann PJ16, Schomburg L17, Köhrle J18 |
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Abstract CONTEXT: Selenium supplementation has been suggested for Hashimoto thyroiditis and Graves' ophthalmopathy. Objective, Design: Our aim is to measure selenium status (p-Se, p-SePP), urine iodine (UI) levels and urine iodine/creatinine ratio (UI/C) in different thyroid diseases (n = 416) from four European countries and to compare the results between patients with and without thyroid autoimmunity. RESULTS: p-Se and p-SePP showed positive correlation and did not correlate with UI/C. Also, these measurements were higher in patients from Italy in comparison with the other countries. Austria had the lowest UI/C ratios. Selenium deficiency exists in these four European countries. Selenium status was lower in patients with Hashimoto thyroiditis and Graves' disease in comparison with non-autoimmune thyroid disease patients and did not differ between autoimmune patients with or without thyroid peroxidase antibodies. The latter correlated positively with age. CONCLUSIONS: Our findings suggest that Se supplementation might have a beneficial effect in autoimmune thyroid patients. |
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KEYWORDS: Graves’ disease, Hashimoto’s thyroiditis, non-autoimmune thyroid disease, plasma selenium, plasma selenoprotein P, selenium status, thyroid diseases, urine iodine |
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Publikations ID: 30736204 Quelle: öffnen |
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