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    Nature genetics. 2017 Mar 27. pii: ng.3826. doi: 10.1038/ng.3826
    Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
    Phelan CM1,  Kuchenbaecker KB2,  Tyrer JP3,  Kar SP4,  Lawrenson K5,  Winham SJ6,  Dennis J7,  Pirie A8,  Riggan MJ9,  Chornokur G10,  Earp MA11,  Lyra PC12,  Lee JM13,  Coetzee S14,  Beesley J15,  McGuffog L16,  Soucy P17,  Dicks E18,  Lee A19,  Barrowdale D20,  Lecarpentier J21,  Leslie G22,  Aalfs CM23,  Aben KK24,  Adams M25,  Adlard J26,  Andrulis IL27,  Anton-Culver H28,  Antonenkova N29,  Aravantinos G30,  Arnold N31,  Arun BK32,  Arver B33,  Azzollini J34,  Balmaña J35,  Banerjee SN36,  Barjhoux L37,  Barkardottir RB38,  Bean Y39,  Beckmann MW40,  Beeghly-Fadiel A41,  Benitez J42,  Bermisheva M43,  Bernardini MQ44,  Birrer MJ45,  Bjorge L46,  Black A47,  Blankstein K48,  Blok MJ49,  Bodelon C50,  Bogdanova N51,  Bojesen A52,  Bonanni B53,  Borg Å54,  Bradbury AR55,  Brenton JD56,  Brewer C57,  Brinton L58,  Broberg P59,  Brooks-Wilson A60,  Bruinsma F61,  Brunet J62,  Buecher B63,  Butzow R64,  Buys SS65,  Caldes T66,  Caligo MA67,  Campbell I68,  Cannioto R69,  Carney 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Glendon G138,  Godwin AK139,  Goldgar DE140,  Goranova T141,  Gore M142,  Greene MH143,  Gronwald J144,  Gruber S145,  Hahnen E146,  Haiman CA147,  Håkansson N148,  Hamann U149,  Hansen TV150,  Harrington PA151,  Harris HR152,  Hauke J153,  Hein A154,  Henderson A155,  Hildebrandt MA156,  Hillemanns P157,  Hodgson S158,  Høgdall CK159,  Høgdall E160,  Hogervorst FB161,  Holland H162,  Hooning MJ163,  Hosking K164,  Huang RY165,  Hulick PJ166,  Hung J167,  Hunter DJ168,  Huntsman DG169,  Huzarski T170,  Imyanitov EN171,  Isaacs C172,  Iversen ES173,  Izatt L174,  Izquierdo A175,  Jakubowska A176,  James P177,  Janavicius R178,  Jernetz M179,  Jensen A180,  Jensen UB181,  John EM182,  Johnatty S183,  Jones ME184,  Kannisto P185,  Karlan BY186,  Karnezis A187,  Kast K188,  Kennedy CJ189,  Khusnutdinova E190,  Kiemeney LA191,  Kiiski JI192,  Kim SW193,  Kjaer SK194,  Köbel M195,  Kopperud RK196,  Kruse TA197,  Kupryjanczyk J198,  Kwong A199,  Laitman Y200,  Lambrechts D201,  Larrañaga 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    Author information
    1Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    2Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
    3Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    4Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    5Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    6Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
    7Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    8Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    9Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
    10Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    11Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
    12Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    13Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    14Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    15Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    16Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    17Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Quebec, Canada.
    18Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    19Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    20Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    21Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    22Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    23Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
    24Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, the Netherlands.
    25Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    26Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
    27Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital and Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
    28Genetic Epidemiology Research Institute, UCI Center for Cancer Genetics Research and Prevention, School of Medicine, University of California-Irvine, Irvine, California, USA.
    29N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
    30'Agii Anargiri' Cancer Hospital, Athens, Greece.
    31Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian Albrechts University Kiel, Kiel, Germany.
    32Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    33Department of Oncology and Pathology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden.
    34Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
    35Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain.
    36Gynaecology Unit, Royal Marsden Hospital, London, UK.
    37Bâtiment Cheney D, Centre Léon Bérard, Lyon, France.
    38Laboratory of Cell Biology, Department of Pathology, Landspitali, Reykjavik, Iceland.
    39Department of Gynecologic Oncology, Oregon Health &Science University, Portland, Oregon, USA.
    40Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany.
    41Division of Epidemiology, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
    42Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
    43Institute of Biochemistry and Genetics, Ufa Science Center, Russian Academy of Sciences, Ufa, Russian Federation.
    44Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
    45Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
    46Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
    47Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    48Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
    49Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
    50Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    51Radiation Oncology Research Unit, Hannover Medical School, Hannover, Germany.
    52Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
    53Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), Milan, Italy.
    54Department of Oncology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.
    55Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    56Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.
    57Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK.
    58Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    59Department of Cancer Epidemiology, University Hospital, Lund, Lund University, Lund, Sweden.
    60Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
    61Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
    62Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain.
    63Service de Génétique Oncologique, Institut Curie, Paris, France.
    64Department of Pathology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
    65Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
    66Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
    67Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.
    68Cancer Genetics Laboratory, Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    69Cancer Pathology and Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA.
    70Department of Obstetrics and Gynecology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.
    71Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
    72Cancer Risk Program, University of California, San Francisco, San Francisco, California, USA.
    73Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    74Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    75Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    76Centre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
    77Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Centre de Recherche FRSQ du Centre Hospitalier Affilié Universitaire de Québec, Quebec City, Quebec, Canada.
    78Departments of Pediatrics and Medicine, Columbia University, New York, New York, USA.
    79Center for Medical Genetics, Ghent University, Ghent, Belgium.
    80Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
    81Division of Epidemiology, Biostatistics and Preventative Medicine, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA.
    82Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK.
    83Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    84Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    85Social &Scientific Systems, Inc., Durham, North Carolina, USA.
    86Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
    87Bâtiment Cheney D, Centre Léon Bérard, Lyon, France.
    88Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation.
    89Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
    90Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    91Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK.
    92Centre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
    93Unité d'Oncogénétique, ICO-Centre René Gauducheau, Nantes, France.
    94Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    95Oncogenetics Group, Vall d'Hebron Institute of Oncology, Barcelona, Spain.
    96Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
    97Department of Epidemiology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
    98Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    99Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Pretoria, South Africa.
    100Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
    101Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
    102Institute of Biology and Molecular Genetics, Universidad de Valladolid (IBGM-UVA), Valladolid, Spain.
    103Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.
    104Institute of Human Genetics, Münster, Germany.
    105University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, UK.
    106Division of Epidemiology, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
    107Oncogenetics Team, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK.
    108Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    109Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    110Institute of Human Genetics, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
    111Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    112Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation.
    113Department of Biostatistics and Bioinformatics, Roswell Park Institute, Buffalo, New York, USA.
    114Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
    115Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
    116Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany.
    117Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
    118Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France.
    119Department of Surgery and Cancer, Imperial College London, London, UK.
    120Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
    121Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    122Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
    123Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.
    124Department of Medical Oncology, Papageorgiou, Hospital, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece.
    125Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, USA.
    126Harvard T.H. Chan School of Public Health and Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    127Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.
    128Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    129Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, UCLA Schools of Medicine and Public Health, Los Angeles, California, USA.
    130Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    131Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
    132Molecular Oncology Laboratory, Hospital Clínico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain.
    133Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
    134Women's Cancer, Institute for Women's Health, University College London, London, UK.
    135Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    136Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
    137Beatson West of Scotland Cancer Centre, Glasgow, UK.
    138Ontario Cancer Genetics Network: Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.
    139Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
    140Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
    141Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.
    142Department of Medicine, Royal Marsden Hospital, London, UK.
    143Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
    144Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    145Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.
    146Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany.
    147Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
    148Division of Nutritional Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    149Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
    150Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    151Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    152Division of Nutritional Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    153Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany.
    154Department of Gynecology and Obstetrics, Universtiy Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany.
    155Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK.
    156Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    157Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
    158Medical Genetics Unit, St George's University of London, London, UK.
    159Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    160Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
    161Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands.
    162Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    163Department of Medical Oncology, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands.
    164Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    165Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, New York, USA.
    166Center for Medical Genetics, NorthShore University HealthSystem, University of Chicago Pritzker School of Medicine, Evanston, Illinois, USA.
    167Centre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
    168Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    169Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    170Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    171N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation.
    172Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
    173Department of Statistical Science, Duke University, Durham, North Carolina, USA.
    174Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
    175Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain.
    176Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    177Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    178Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medicine Center, Vilnius University Hospital Santariskiu Clinics, Vilnius, Lithuania.
    179Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.
    180Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
    181Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
    182Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA.
    183Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    184Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
    185Department of Obstetrics and Gynecology, Lund University Hospital, Lund, Sweden.
    186Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    187Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    188Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
    189Centre for Cancer Research, Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
    190Institute of Biochemistry and Genetics, Ufa Science Center, Russian Academy of Sciences, Ufa, Russian Federation.
    191Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, the Netherlands.
    192Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    193Department of Surgery, Breast Care Center, Daerim St. Mary's Hospital, Seoul, Republic of Korea.
    194Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    195Department of Pathology, University of Calgary, Calgary, Alberta, Canada.
    196Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
    197Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
    198Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
    199Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong.
    200Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.
    201Vesalius Research Center, VIB, Leuven, Belgium.
    202Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Donostia-San Sebastian, Spain.
    203Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
    204Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain.
    205Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
    206Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
    207Department of Surgery, Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
    208Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
    209Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    210Département de Génétique, Centre Hospitalier Universitaire de Grenoble, Grenoble, France.
    211Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    212Institut Curie, PSL Research Unviersity and INSERM U900, Paris, France.
    213Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    214College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA.
    215Cancer Center Wolfsburg, Clinics of Gynaecology, Wolfsburg, Germany.
    216Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
    217Division of Epidemiology, Department of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee, USA.
    218Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
    219Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    220Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    221Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    222Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    223Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
    224Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    225Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
    226Radboud University Medical Center, Radboud Institute for Health Sciences, Department for Health Evidence, Nijmegen, the Netherlands.
    227Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
    228INSERM U1052, CNRS UMR 5286, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, Centre Léon Bérard, Lyon, France.
    229Ovarian Cancer Research (OVCARE) Program-Gynecologic Tissue Bank, Vancouver General Hospital and BC Cancer Agency, Vancouver, British Columbia, Canada.
    230Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
    231Public Health Ontario, Toronto, Ontario, Canada.
    232Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK.
    233Department of Clinical Genetics, VU University Medical Centre, Amsterdam, the Netherlands.
    234Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
    235Women's Cancer, Institute for Women's Health, University College London, London, UK.
    236Department of Human Genetics, Radboud University Medical Centre, Nijmegen, the Netherlands.
    237Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
    238Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
    239Familial Cancer Centre, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
    240Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    241Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
    242Knight Cancer Institute, Oregon Health &Science University, Portland, Oregon, USA.
    243Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
    244Cancer Pathology and Prevention, Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA.
    245Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
    246Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    247Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    248Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    249University of Texas School of Public Health, Houston, Texas, USA.
    250Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
    251Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    252Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
    253Invitae Corporation, San Francisco, California, USA.
    254Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
    255Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
    256Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA.
    257Department of Cancer Epidemiology, University Hospital, Lund, Lund University, Lund, Sweden.
    258Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
    259Department of Obstetrics and Gynecology, Ohio State University and the James Cancer Center, Columbus, Ohio, USA.
    260West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK.
    261Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
    262Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK.
    263Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    264Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.
    265Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute-ISPO, Florence, Italy.
    266Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
    267Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
    268Cancer Research UK Clinical Trials Unit, Institute of Cancer Sciences, University of Glasgow, Glasgow, UK.
    269Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
    270Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
    271Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.
    272Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
    273Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
    274Knight Cancer Institute, Oregon Health &Science University, Portland, Oregon, USA.
    275Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
    276Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    277IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
    278Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
    279Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
    280Centre for Epidemiology and Biostatistics, School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
    281NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA.
    282Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
    283Cancer Research UK (CRUK) Cambridge Institute, University of Cambridge, Cambridge, UK.
    284Department of Gynecological Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA.
    285Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
    286Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    287Center for Medical Genetics, Ghent University, Ghent, Belgium.
    288South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK.
    289Service de Génétique Clinique Chromosomique et Moléculaire, Centre Hospitalier Universitaire de St Etienne, St Etienne, France.
    290Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation.
    291Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    292Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
    293Unité d'Oncogénétique, Centre Hospitalier Universitaire Arnaud de Villeneuve, Montpellier, France.
    294Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Milan, Italy.
    295Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
    296Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
    297Clalit National Israeli Cancer Control Center, Haifa, Israel.
    298Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany.
    299Clinical Cancer Genetics for the City of Hope, Clinical Cancer Genetics Community Research Network, Duarte, California, USA.
    300Department of Pathology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    301Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    302Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA.
    303Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
    304Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    305Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
    306Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
    307Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
    308Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    309Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany.
    310Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
    311Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
    312Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
    313Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
    314Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
    315Facultés de Médecin, Université Paris-Sud, Villejuif, France.
    316Department of Hematology and Oncology, University of Kansas Medical Center, Kansas City, Kansas, USA.
    317Center for Inherited Disease Research, Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    318Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK.
    319North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK.
    320Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
    321Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
    322Département Oncologie Génétique, Institut Paoli-Calmettes, Marseille, France.
    323Department of Oncology, Centre for Cancer Genetic Epidemiology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    324Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
    325Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    326Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    327Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
    328Service de Génétique Oncologique, Institut Curie, Paris, France.
    329Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA.
    330Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    331Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida, USA.
    332Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
    333Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
    334National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
    335Department of Pathology and Laboratory Diagnostics, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
    336Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
    337Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
    338Department of Obstetrics and Gynecology, Medical University of Vienna and Comprehensive Cancer Center, Vienna, Austria.
    339Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
    340Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia.
    341Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    342Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    343Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.
    344Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    345Latvian Biomedical Research and Study Centre, Riga, Latvia.
    346Ovarian Cancer Research (OVCARE) Program-Cheryl Brown Ovarian Cancer Outcomes Unit (CBOCOU), BC Cancer Agency, Vancouver, British Columbia, Canada.
    347Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.
    348Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Padua, Italy.
    349Division of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
    350Division of Gynecologic Oncology, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada.
    351Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    352Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
    353Hellenic Health Foundation, Athens, Greece.
    354Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
    355Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
    356Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands.
    357Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
    358Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
    359Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
    360Center for Medical Genetics, Ghent University, Ghent, Belgium.
    361Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
    362Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Pretoria, South Africa.
    363Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
    364Institute of Medical and Human Genetics, Charité Universitätsmedizin, Campus Virchov Klinikum, Berlin, Germany.
    365Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde (SERGAS), Instituto de Investigación Sanitaria (IDIS), Santiago de Compostela, Spain.
    366Vanderbilt Epidemiology Center, Department of Medicine, Vanderbilt Medical School, Nashville, Tennessee, USA.
    367Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
    368Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
    369Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    370Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
    371Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK.
    372Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    373Institute of Human Genetics, University Hospital, Leipzig, Germany.
    374Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
    375Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany.
    376Population Health Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.
    377Biostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
    378Clinical Cancer Genetics, City of Hope, Duarte, California, USA.
    379Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    380Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA.
    381Departments of Human Genetics and Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
    382Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
    383Division of Nutritional Epidemiology, Department of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    384Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
    385Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    386Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA.
    387Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    388Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece.
    389Department of Epidemiology, University of California-Irvine, Irvine, California, USA.
    390Magee-Womens Hospital of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    391Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
    392Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    393Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA.
    394Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA.
    395School of Women's and Children's Health, Lowy Cancer Research Centre, University of New South Wales, Sydney, New South Wales, Australia.
    396Department of Molecular Medicine, University La Sapienza, Rome, Italy.
    397Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    398Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
    399Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
    400Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA.
    401Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
    402Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    403Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec City, Quebec, Canada.
    404Center for Familial Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany.
    405Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    406Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    407Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    408Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA.
    409Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    410Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA.
    411Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    412Center for Bioinformatics and Functional Genomics, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
    413Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    414Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK.
    Abstract

    To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.


    Publikations ID: 28346442
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