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    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2015 Mar 31. pii: S1083-8791(15)00224-4. doi: 10.1016/j.bbmt.2015.03.024
    National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: V. The 2014 Ancillary Therapy and Supportive Care Working Group Report.
    Carpenter PA1,  Kitko CL2,  Elad S3,  Flowers ME4,  Gea-Banacloche JC5,  Halter JP6,  Hoodin F7,  Johnston L8,  Lawitschka A9,  McDonald GB10,  Opipari AW11,  Savani BN12,  Schultz KR13,  Smith SR14,  Syrjala KL15,  Treister N16,  Vogelsang GB17,  Williams KM18,  Pavletic SZ19,  Martin PJ20,  Lee SJ21,  Couriel DR22
    Author information
    1Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. Electronic address: pcarpent@fredhutch.org.
    2Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
    3Division of Oral Medicine, Eastman Institute for Oral Health and Wilmot Cancer Center, University of Rochester Medical Center, Rochester, New York.
    4Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
    5Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
    6Department of Hematology, University Hospital Basel, Basel, Switzerland.
    7Department of Psychology, Eastern Michigan University, Ypsilanti, Michigan.
    8Department of Blood and Marrow Transplantation, Stanford University Medical Center, Stanford, California.
    9St. Anna Children's Hospital, Medical University, Vienna, Austria.
    10Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
    11Department of Obstetrics and Gynecology, University of Michigan Health System, Ann Arbor, Michigan.
    12Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
    13Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital and University of BC, Vancouver, British Columbia.
    14Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan.
    15Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
    16Division of Oral Medicine and Dentistry, Dana-Farber/Brigham and Women's Cancer Center, Boston, Massachusetts.
    17Oncology Department, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    18Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
    19Center for Cancer Research National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
    20Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
    21Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
    22Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan.
    Abstract

    The 2006 National Institutes of Health (NIH) Consensus paper presented recommendations by the Ancillary Therapy and Supportive Care Working Group to support clinical research trials in chronic graft-versus-host disease (GVHD). Topics covered in that inaugural effort included the prevention and management of infections and common complications of chronic GVHD, as well as recommendations for patient education and appropriate follow-up. Given the new literature that has emerged during the past 8 years, we made further organ-specific refinements to these guidelines. Minimum frequencies are suggested for monitoring key parameters relevant to chronic GVHD during systemic immunosuppressive therapy and, thereafter, referral to existing late effects consensus guidelines is advised. Using the framework of the prior consensus, the 2014 NIH recommendations are organized by organ or other relevant systems and graded according to the strength and quality of supporting evidence.


    Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

    KEYWORDS: Allogeneic hematopoietic cell transplantation, Chronic graft-versus-host disease, Consensus, Guidelines, Supportive care

    Publikations ID: 25838185
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