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| European urology. 2020 Jul 2. pii: S0302-2838(20)30507-8. doi: 10.1016/j.eururo.2020.06.047 |
| Assessing the Best Surgical Template at Salvage Pelvic Lymph Node Dissection for Nodal Recurrence of Prostate Cancer After Radical Prostatectomy: When Can Bilateral Dissection be Omitted? Results from a Multi-institutional Series. |
| Bravi CA1, Fossati N2, Gandaglia G3, Suardi N4, Mazzone E5, Robesti D6, Osmonov D7, Juenemann KP8, Boeri L9, Jeffrey Karnes R10, Kretschmer A11, Buchner A12, Stief C13, Hiester A14, Nini A15, Albers P16, Devos G17, Joniau S18, Van Poppel H19, Shariat SF20, Heidenreich A21, Pfister D22, Tilki D23, Graefen M24, Gill IS25, Mottrie A26, Karakiewicz PI27, Montorsi F28, Briganti A29 |
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Abstract The best surgical template for salvage pelvic lymph node dissection (sLND) in patients with nodal recurrence from prostate cancer (PCa) after radical prostatectomy (RP) is currently unknown. We analyzed data of 189 patients with a unilateral positive positron emission tomography (PET) scan of the pelvic lymph node areas, who were treated with bilateral pelvic sLND after RP at 11 high-volume centers. The primary endpoint was missed contralateral disease at final pathology, defined as lymph node positive for PCa in the side opposite to the positive spot(s) at the PET scan. Overall, 93 (49%) and 96 (51%) patients received a C-choline and a Ga prostate-specific membrane antigen (PSMA) PET scan, respectively, and 171 (90%) and 18 (10%) men had one and two positive spots, respectively. The rate of missed contralateral PCa was 18% (34/189), with the rates being 17% (29/171) and 28% (5/18) in men with one and two positive spots, respectively. While the rate of contralateral disease did not differ between Ga-PSMA and C-choline (29% and 27%, respectively) among men with two positive spots, the rate of contralateral PCa was only 6% with Ga-PSMA versus 28% with C-choline in patients with a single positive spot. This finding was confirmed at multivariable logistic regression analysis predicting missed disease at final pathology after accounting for confounders (odds ratio: 0.24; p = 0.001). However, in men with a single positive spot at Ga-PSMA PET/computed tomography, the rate of single confirmed lymph node metastasis at final pathology was only 33%, suggesting the need for extended template even if unilateral dissection is performed. Awaiting confirmatory studies, patients diagnosed with a single positive spot at the Ga-PSMA PET scan might be considered for unilateral extended pelvic sLND. PATIENT SUMMARY: We assessed the risk of missing contralateral disease in patients with a positron emission tomography (PET) scan suggestive of unilateral nodal recurrence from prostate cancer (PCa) after radical prostatectomy and who were treated with bilateral salvage lymph node dissection (sLND). Variability exists according to the number of positive spots and PET tracer, with the lowest rate of missed PCa in men diagnosed with a single positive spot at a Ga prostate-specific membrane antigen PET scan (6%). If replicated, our data suggest that these patients might be considered for unilateral extended pelvic sLND. |
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Copyright © 2020. Published by Elsevier B.V. |
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KEYWORDS: (11)C-choline positron emission tomography scan, (68)Ga prostate-specific membrane antigen positron emission tomography scan, Metastasis-directed therapy, Neoplasm recurrence, Prostate cancer, Salvage lymph node dissection, Surgical template, Unilateral dissection |
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Publikations ID: 32624281 Quelle: öffnen |
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