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    Nature communications. 2020 Jun 16. doi: 10.1038/s41467-020-16765-w. pii: 10.1038/s41467-020-16765-w
    Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer.
    Strakova A1,  Nicholls TJ2,  Baez-Ortega A3,  Ní Leathlobhair M4,  Sampson AT5,  Hughes K6,  Bolton IAG7,  Gori K8,  Wang J9,  Airikkala-Otter I10,  Allen JL11,  Allum KM12,  Arnold CL13,  Bansse-Issa L14,  Bhutia TN15,  Bisson JL16,  Blank K17,  Briceño C18,  Castillo Domracheva A19,  Corrigan AM20,  Cran HR21,  Crawford JT22,  Cutter SM23,  Davis E24,  de Castro KF25,  De Nardi AB26,  de Vos AP27,  Delgadillo Keenan L28,  Donelan EM29,  Espinoza Huerta AR30,  Faramade IA31,  Fazil M32,  Fotopoulou E33,  Fruean SN34,  Gallardo-Arrieta F35,  Glebova O36,  Gouletsou PG37,  Häfelin Manrique RF38,  Henriques JJGP39,  Horta RS40,  Ignatenko N41,  Kane Y42,  King C43,  Koenig D44,  Krupa A45,  Kruzeniski SJ46,  Lanza-Perea M47,  Lazyan M48,  Lopez Quintana AM49,  Losfelt T50,  Marino G51,  Martínez Castañeda S52,  Martínez-López MF53,  Masuruli BM54,  Meyer M55,  Migneco EJ56,  Nakanwagi B57,  Neal KB58,  Neunzig W59,  Nixon SJ60,  Ortega-Pacheco A61,  Pedraza-Ordoñez F62,  Peleteiro MC63,  Polak K64,  Pye RJ65,  Ramirez-Ante JC66,  Reece JF67,  Rojas Gutierrez J68,  Sadia H69,  Schmeling SK70,  Shamanova O71,  Sherlock AG72,  Steenland-Smit AE73,  Svitich A74,  Tapia Martínez LJ75,  Thoya Ngoka I76,  Torres CG77,  Tudor EM78,  van der Wel MG79,  Vițălaru BA80,  Vural SA81,  Walkinton O82,  Wehrle-Martinez AS83,  Widdowson SAE84,  Zvarich I85,  Chinnery PF86,  Falkenberg M87,  Gustafsson CM88,  Murchison EP89
    Author information
    1Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    2Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
    3Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    4Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    5Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    6Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    7Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    8Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    9Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    10Worldwide Veterinary Service, International Training Center, Tamil Nadu, India.
    11Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
    12World Vets, Gig Harbor, USA.
    13Hopkins Belize Humane Society, Hopkins, Belize.
    14Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
    15Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, Sikkim, India.
    16Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    17Hopkins Belize Humane Society, Hopkins, Belize.
    18ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.
    19Corozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.
    20St. George's University, True Blue, Grenada.
    21The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
    22Animal Medical Centre, Belize City, Belize.
    23Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
    24International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, USA.
    25Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.
    26School of Agricultural and Veterinary Sciences, São Paulo State University (UNESP), Jaboticabal, Brazil.
    27Ladybrand Animal Clinic, Ladybrand, South Africa.
    28Veterinary Clinic Sr. Dog's, Guadalajara, Mexico.
    29Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
    30World Vets Latin America Veterinary Training Center, Granada, Nicaragua.
    31National Veterinary Research Institute, Vom, Nigeria.
    32Animal Clinic, Mombasa, Kenya.
    33Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.
    34Animal Protection Society of Samoa, Apia, Samoa.
    35Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.
    36Veterinary Clinic BIOCONTROL, Moscow, Russia.
    37Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.
    38Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.
    39OnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.
    40Universidade Vila Velha, Vila Velha, Brazil.
    41Veterinary Clinic Zoovetservis, Kiev, Ukraine.
    42École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.
    43World Vets, Gig Harbor, USA.
    44World Vets, Gig Harbor, USA.
    45Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
    46World Vets Latin America Veterinary Training Center, Granada, Nicaragua.
    47St. George's University, True Blue, Grenada.
    48Vetexpert Veterinary Group, Yerevan, Armenia.
    49Lopez Quintana Veterinary Clinic, Maldonado, Uruguay.
    50Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.
    51Department of Veterinary Sciences, University of Messina, Messina, Italy.
    52Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.
    53School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.
    54Veterinary Council of Tanzania, Dar-es-Salaam, Tanzania.
    55Touray & Meyer Vet Clinic, Serrekunda, The Gambia.
    56Hillside Animal Hospital, St. Louis, USA.
    57The Kampala Veterinary Surgery, Kampala, Uganda.
    58Asavet Veterinary Charities, Tucson, USA.
    59World Vets, Gig Harbor, USA.
    60Vets Beyond Borders, Bylakuppe, India.
    61Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.
    62Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.
    63Centre for Interdisciplinary Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.
    64Four Paws International, Vienna, Austria.
    65Vets Beyond Borders, The Rocks, Australia.
    66Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.
    67Help in Suffering, Jaipur, India.
    68Veterinary Clinic Dr José Rojas, Los Andes, Chile.
    69Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.
    70Corozal Veterinary Clinic, Corozal Town, Belize.
    71Veterinary Clinic Vetmaster, Ramenskoye, Russia.
    72Vets Beyond Borders, The Rocks, Australia.
    73Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
    74State Hospital of Veterinary Medicine, Kamianske, Ukraine.
    75World Vets Latin America Veterinary Training Center, Granada, Nicaragua.
    76Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
    77Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.
    78Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.
    79Animal Anti Cruelty League, Port Elizabeth, South Africa.
    80Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.
    81Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.
    82Vets Beyond Borders, The Rocks, Australia.
    83Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.
    84Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.
    85Veterinary clinic Canine Heart, Yelizovo, Russia.
    86MRC-Mitochondrial Biology Unit & Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
    87Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
    88Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden.
    89Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. epm27@cam.ac.uk.
    Abstract

    Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for 'selfish' traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby 'selfish' positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.


    Publikations ID: 32546718
    Quelle: öffnen
     
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