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    Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2015 Aug 24. pii: JCO.2014.59.4648. doi: 10.1200/JCO.2014.59.4648
    Advances in Risk Classification and Treatment Strategies for Neuroblastoma.
    Pinto NR1,  Applebaum MA2,  Volchenboum SL3,  Matthay KK4,  London WB5,  Ambros PF6,  Nakagawara A7,  Berthold F8,  Schleiermacher G9,  Park JR10,  Valteau-Couanet D11,  Pearson AD12,  Cohn SL13
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    Abstract

    Risk-based treatment approaches for neuroblastoma have been ongoing for decades. However, the criteria used to define risk in various institutional and cooperative groups were disparate, limiting the ability to compare clinical trial results. To mitigate this problem and enhance collaborative research, homogenous pretreatment patient cohorts have been defined by the International Neuroblastoma Risk Group classification system. During the past 30 years, increasingly intensive, multimodality approaches have been developed to treat patients who are classified as high risk, whereas patients with low- or intermediate-risk neuroblastoma have received reduced therapy. This treatment approach has resulted in improved outcome, although survival for high-risk patients remains poor, emphasizing the need for more effective treatments. Increased knowledge regarding the biology and genetic basis of neuroblastoma has led to the discovery of druggable targets and promising, new therapeutic approaches. Collaborative efforts of institutions and international cooperative groups have led to advances in our understanding of neuroblastoma biology, refinements in risk classification, and stratified treatment strategies, resulting in improved outcome. International collaboration will be even more critical when evaluating therapies designed to treat small cohorts of patients with rare actionable mutations.


    © 2015 by American Society of Clinical Oncology.

    Publikations ID: 26304901
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