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Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance. |
Miklos W, Pelivan K, Kowol CR, Pirker C, Dornetshuber-Fleiss R, Spitzwieser M, Englinger B, van Schoonhoven S, Cichna-Markl M, Koellensperger G, Keppler BK, Berger W, Heffeter P |
Cancer letters. 2015 Mar 5. pii: S0304-3835(15)00164-0. doi: 10.1016/j.canlet.2015.02.049 |
PMID: 25749419 |
The ruthenium compound KP1339 potentiates the anticancer activity of sorafenib in vitro and in vivo. |
Heffeter P, Atil B, Kryeziu K, Groza D, Koellensperger G, Körner W, Jungwirth U, Mohr T, Keppler BK, Berger W |
European journal of cancer (Oxford, England : 1990). 2013 Jun 18. pii: S0959-8049(13)00426-7. doi: 10.1016/j.ejca.2013.05.018. pmc: PMC3807657 |
PMID: 23790465 |
Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones. |
Heffeter P, Pirker C, Kowol CR, Herrman G, Dornetshuber R, Miklos W, Jungwirth U, Koellensperger G, Keppler BK, Berger W |
Biochemical pharmacology. 2012 Mar 15. pii: S0006-2952(12)00196-7. doi: 10.1016/j.bcp.2012.03.004. pmc: PMC3342514 |
PMID: 22426010 |
Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339. |
Heffeter P, Böck K, Atil B, Reza Hoda MA, Körner W, Bartel C, Jungwirth U, Keppler BK, Micksche M, Berger W, Koellensperger G |
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2010 Mar 11. doi: 10.1007/s00775-010-0642-1. pmc: PMC3371400. mid: UKMS48674 |
PMID: 20221888 |
An albumin-based tumor-targeted oxaliplatin prodrug with distinctly improved anticancer activity in vivo. |
Mayr J, Heffeter P, Groza D, Galvez L, Koellensperger G, Roller A, Alte B, Haider M, Berger W, Kowol CR, Keppler BK |
Chemical science. 2016 Dec 15. doi: 10.1039/c6sc03862j. pii: c6sc03862j. pmc: PMC5409245 |
PMID: 28507680 |
Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis. |
Schoenhacker-Alte B, Mohr T, Pirker C, Kryeziu K, Kuhn PS, Buck A, Hofmann T, Gerner C, Hermann G, Koellensperger G, Keppler BK, Berger W, Heffeter P |
Cancer letters. 2017 Jul 14. pii: S0304-3835(17)30435-4. doi: 10.1016/j.canlet.2017.07.009 |
PMID: 28716523 |
Understanding the metabolism of the anticancer drug Triapine: electrochemical oxidation, microsomal incubation and in vivo analysis using LC-HRMS. |
Pelivan K, Frensemeier L, Karst U, Koellensperger G, Bielec B, Hager S, Heffeter P, Keppler BK, Kowol CR |
The Analyst. 2017 Jul 26. doi: 10.1039/c7an00902j |
PMID: 28745337 |
Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins. |
Heilos D, Röhrl C, Pirker C, Englinger B, Baier D, Mohr T, Schwaiger M, Iqbal SM, van Schoonhoven S, Klavins K, Eberhart T, Windberger U, Taibon J, Sturm S, Stuppner H, Koellensperger G, Dornetshuber-Fleiss R, Jäger W, Lemmens-Gruber R, Berger W |
Oncotarget. 2018 May 22. doi: 10.18632/oncotarget.25432. pii: 25432. pmc: PMC5986646 |
PMID: 29876015 |
Serum-binding properties of isosteric ruthenium and osmium anticancer agents elucidated by SEC-ICP-MS. |
Klose MHM, Schöberl A, Heffeter P, Berger W, Hartinger CG, Koellensperger G, Meier-Menches SM, Keppler BK |
Monatshefte fur chemie. 2018 Aug 25. doi: 10.1007/s00706-018-2280-1. pii: 2280. pmc: PMC6133104 |
PMID: 30237619 |
Synthesis, Modification, and Biological Evaluation of a Library of Novel Water-Soluble Thiopyridone-Based Organometallic Complexes and Their Unexpected (Biological) Behavior. |
Harringer S, Happl B, Ozenil M, Kast C, Hejl M, Wernitznig D, Legin AA, Schweikert A, Gajic N, Roller A, Koellensperger G, Jakupec MA, Kandioller W, Keppler BK |
Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Jan 20. doi: 10.1002/chem.201905546 |
PMID: 31958176 |
STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer. |
Oberhuber M, Pecoraro M, Rusz M, Oberhuber G, Wieselberg M, Haslinger P, Gurnhofer E, Schlederer M, Limberger T, Lagger S, Pencik J, Kodajova P, Högler S, Stockmaier G, Grund-Gröschke S, Aberger F, Bolis M, Theurillat JP, Wiebringhaus R, Weiss T, Haitel A, Brehme M, Wadsak W, Griss J, Mohr T, Hofer A, Jäger A, Pollheimer J, Egger G, Koellensperger G, Mann M, Hantusch B, Kenner L |
Molecular systems biology. doi: 10.15252/msb.20199247 |
PMID: 32323921 |
Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy. |
Theiner S, Schweikert A, Haberler C, Peyrl A, Koellensperger G |
Metallomics : integrated biometal science. 2020 Jun 11. doi: 10.1039/d0mt00080a |
PMID: 32525499 |
An Organometallic Gold(I) Bis-N-Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells. |
Meier-Menches SM, Neuditschko B, Zappe K, Schaier M, Gerner MC, Schmetterer KG, Del Favero G, Bonsignore R, Cichna-Markl M, Koellensperger G, Casini A, Gerner C |
Chemistry (Weinheim an der Bergstrasse, Germany). 2020 Sep 9. doi: 10.1002/chem.202003495 |
PMID: 32902006 |
Thermodynamic Genome-Scale Metabolic Modeling of Metallodrug Resistance in Colorectal Cancer. |
Herrmann HA, Rusz M, Baier D, Jakupec MA, Keppler BK, Berger W, Koellensperger G, Zanghellini J |
Cancers. 2021 Aug 17. pii: cancers13164130. doi: 10.3390/cancers13164130 |
PMID: 34439283 |
Albumin-targeting of an oxaliplatin-releasing platinum(iv) prodrug results in pronounced anticancer activity due to endocytotic drug uptake . |
Schueffl H, Theiner S, Hermann G, Mayr J, Fronik P, Groza D, van Schonhooven S, Galvez L, Sommerfeld NS, Schintlmeister A, Reipert S, Wagner M, Mader RM, Koellensperger G, Keppler BK, Berger W, Kowol CR, Legin A, Heffeter P |
Chemical science. 2021 Aug 26. doi: 10.1039/d1sc03311e. pii: d1sc03311e. pmc: PMC8494022 |
PMID: 34703544 |
Cisplatin Uptake in Macrophage Subtypes at the Single-Cell Level by LA-ICP-TOFMS Imaging. |
Schoeberl A, Gutmann M, Theiner S, Schaier M, Schweikert A, Berger W, Koellensperger G |
Analytical chemistry. 2021 Nov 30. doi: 10.1021/acs.analchem.1c03442 |
PMID: 34846133 |
The Anticancer Ruthenium Compound BOLD-100 Targets Glycolysis and Generates a Metabolic Vulnerability towards Glucose Deprivation. |
Baier D, Schoenhacker-Alte B, Rusz M, Pirker C, Mohr T, Mendrina T, Kirchhofer D, Meier-Menches SM, Hohenwallner K, Schaier M, Rampler E, Koellensperger G, Heffeter P, Keppler B, Berger W |
Pharmaceutics. 2022 Jan 20. pii: pharmaceutics14020238. doi: 10.3390/pharmaceutics14020238 |
PMID: 35213972 |
Quantification in bioimaging by LA-ICPMS - Evaluation of isotope dilution and standard addition enabled by micro-droplets. |
Schweikert A, Theiner S, Šala M, Vician P, Berger W, Keppler BK, Koellensperger G |
Analytica chimica acta. 2022 Jul 31. pii: S0003-2670(22)00771-1. doi: 10.1016/j.aca.2022.340200 |
PMID: 35999007 |
Mass spectrometry techniques for imaging and detection of metallodrugs. |
Theiner S, Schoeberl A, Schweikert A, Keppler BK, Koellensperger G |
Current opinion in chemical biology. 2021 Jan 31. doi: 10.1016/j.cbpa.2020.12.005. pii: S1367-5931(20)30164-2 |
PMID: 33535112 |
The copper transporter CTR1 and cisplatin accumulation at the single-cell level by LA-ICP-TOFMS. |
Schoeberl A, Gutmann M, Theiner S, Corte-Rodríguez M, Braun G, Vician P, Berger W, Koellensperger G |
Frontiers in molecular biosciences. 2022 Nov 28. pmc: PMC9742377. doi: 10.3389/fmolb.2022.1055356. pii: 1055356 |
PMID: 36518851 |
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