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| Translational psychiatry. 2023 Feb 1. doi: 10.1038/s41398-023-02334-4. pii: 10.1038/s41398-023-02334-4 |
| Persistent short nighttime sleep duration is associated with a greater post-COVID risk in fully mRNA-vaccinated individuals. |
| Xue P1, Merikanto I2, Chung F3, Morin CM4, Espie C5, Bjorvatn B6, Cedernaes J7, Landtblom AM8, Penzel T9, De Gennaro L10, Holzinger B11, Matsui K12, Hrubos-Strøm H13, Korman M14, Leger D15, Mota-Rolim S16, Bolstad CJ17, Nadorff M18, Plazzi G19, Reis C20, Chan RNY21, Wing YK22, Yordanova J23, Bjelajac AK24, Inoue Y25, Partinen M26, Dauvilliers Y27, Benedict C28 |
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Abstract Short nighttime sleep duration impairs the immune response to virus vaccination, and long nighttime sleep duration is associated with poor health status. Thus, we hypothesized that short (<6 h) and long (>9 h) nighttime sleepers have a higher post-COVID risk than normal nighttime sleepers, despite two doses of mRNA vaccine (which has previously been linked to lower odds of long-lasting COVID-19 symptoms). Post-COVID was defined as experiencing at least one core COVID-19 symptom for at least three months (e.g., shortness of breath). Multivariate logistic regression adjusting for age, sex, BMI, and other factors showed in 9717 respondents (age span 18-99) that two mRNA vaccinations lowered the risk of suffering from post-COVID by about 21% (p < 0.001). When restricting the analysis to double-vaccinated respondents (n = 5918), short and long sleepers exhibited a greater post-COVID risk than normal sleepers (adjusted OR [95%-CI], 1.56 [1.29, 1.88] and 1.87 [1.32, 2.66], respectively). Among respondents with persistent sleep duration patterns during the pandemic compared to before the pandemic, short but not long sleep duration was significantly associated with the post-COVID risk (adjusted OR [95%-CI], 1.59 [1.24, 2.03] and 1.18 [0.70, 1.97], respectively). No significant association between sleep duration and post-COVID symptoms was observed in those reporting positive SARS-CoV-2 test results (n = 538). Our findings suggest that two mRNA vaccinations against SARS-CoV-2 are associated with a lower post-COVID risk. However, this protection may be less pronounced among those sleeping less than 6 h per night. Our findings warrant replication in cohorts with individuals with confirmed SARS-CoV-2 infection. |
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© 2023. The Author(s). |
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Publikations ID: 36726008 Quelle: öffnen |
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