Ageing research reviews. 2022 Oct 21. pii: S1568-1637(22)00209-4. doi: 10.1016/j.arr.2022.101767 |
Potential mechanisms underlying the accelerated cognitive decline in people with chronic low back pain: A scoping review. |
Zhou Z1, Hui ES2, Kranz GS3, Chang JR4, de Luca K5, Pinto SM6, Chan WW7, Yau SY8, Chau BK9, Samartzis D10, Jensen MP11, Wong AYL12 |
Abstract A growing body of evidence has shown that people with chronic low back pain (CLBP) demonstrate significantly greater declines in multiple cognitive domains than people who do not have CLBP. Given the high prevalence of CLBP in the ever-growing aging population that may be more vulnerable to cognitive decline, it is important to understand the mechanisms underlying the accelerated cognitive decline observed in this population, so that proper preventive or treatment approaches can be developed and implemented. The current scoping review summarizes what is known regarding the potential mechanisms underlying suboptimal cognitive performance and cognitive decline in people with CLBP and discusses future research directions. Five potential mechanisms were identified based on the findings from 34 included studies: (1) altered activity in the cortex and neural networks; (2) grey matter atrophy; (3) microglial activation and neuroinflammation; (4) comorbidities associated with CLBP; and (5) gut microbiota dysbiosis. Future studies should deepen the understanding of mechanisms underlying this association so that proper prevention and treatment strategies can be developed. |
Copyright © 2022. Published by Elsevier B.V. |
KEYWORDS: Chronic low back pain, Cognitive decline, Default mode network, Dorsal lateral prefrontal cortex, Medial prefrontal cortex, Neuroinflammation |
Publikations ID: 36280211 Quelle: öffnen |