Journal of sleep research. 2022 Oct 8. doi: 10.1111/jsr.13754 |
Sleep symptoms are essential features of long-COVID - Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II). |
Merikanto I1, Dauvilliers Y2, Chung F3, Wing YK4, de Gennaro L5, Holzinger B6, Bjorvatn B7, Morin CM8, Penzel T9, Benedict C10, Koscec Bjelajac A11, Chan NY12, Espie CA13, Hrubos-Strøm H14, Inoue Y15, Korman M16, Landtblom AM17, Léger D18, Matsui K19, Mota-Rolim S20, Nadorff MR21, Plazzi G22, Reis C23, Yordanova J24, Partinen M25 |
Abstract Many people report suffering from post-acute sequelae of COVID-19 or "long-COVID", but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18-99 years from 16 countries of Asia, Europe, North America and South America (May-Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID. |
© 2022 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society. |
KEYWORDS: COVID-19, excessive daytime sleepiness, fatigue, insomnia, pandemic, post-acute sequelae of COVID-19 |
Publikations ID: 36208038 Quelle: öffnen |