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    Journal of sleep research. 2022 Oct 8. doi: 10.1111/jsr.13754
    Sleep symptoms are essential features of long-COVID - Comparing healthy controls with COVID-19 cases of different severity in the international COVID sleep study (ICOSS-II).
    Merikanto I1,  Dauvilliers Y2,  Chung F3,  Wing YK4,  de Gennaro L5,  Holzinger B6,  Bjorvatn B7,  Morin CM8,  Penzel T9,  Benedict C10,  Koscec Bjelajac A11,  Chan NY12,  Espie CA13,  Hrubos-Strøm H14,  Inoue Y15,  Korman M16,  Landtblom AM17,  Léger D18,  Matsui K19,  Mota-Rolim S20,  Nadorff MR21,  Plazzi G22,  Reis C23,  Yordanova J24,  Partinen M25
    Author information
    1SleepWell Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.
    2Sleep-Wake Disorders Center, Department of Neurology, Gui-de-Chauliac Hospital, Institute for Neurosciences of Montpellier INM, INSERM, University of Montpellier, Montpellier, France.
    3Department of Anesthesiology and Pain Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada.
    4Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
    5Department of Psychology, Sapienza University of Rome, Rome, Italy.
    6Institute for Consciousness and Dream Research, Medical University of Vienna, Wien, Postgraduate Sleep Coaching, Vienna, Austria.
    7Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.
    8Centre de recherche CERVO/Brain Research Center, École de psychologie, Université Laval, Quebec City, Quebec, Canada.
    9Sleep Medicine Center, Charite University Hospital Berlin, Berlin, Germany.
    10Department of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala University, Uppsala, Sweden.
    11Institute for Medical Research and Occupational Health, Zagreb, Croatia.
    12Li Chiu Kong Family Sleep Assessment Unit, Department of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
    13Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
    14Department of Otorhinolaryngology, Akershus University Hospital, Lørenskog, Norway.
    15Department of Somnology, Tokyo Medical University, Tokyo, Japan.
    16Department of Occupational Therapy, Faculty of Health Sciences, Ariel University, Ariel, Israel.
    17Department of Medical Sciences, Neurology, Uppsala University, Uppsala, Sweden.
    18Sleep and Vigilance Center, Hopital Hotel-Dieu de Paris, Paris, France.
    19Department of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Japan.
    20Brain Institute, Physiology and Behavior Department, Federal University of Rio Grande do Norte, Natal, Brazil.
    21Department of Psychology, Mississippi State University, Mississippi State, Mississippi, USA.
    22IRCCS Istituto Delle Scienze Neurologiche di Bologna, Bologna, Italy.
    23Universidade Católica Portuguesa, Católica Research Centre for Psychological-Family and Social Wellbeing, Lisbon, Portugal.
    24Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
    25Department of Clinical Neurosciences, Clinicum, University of Helsinki, Helsinki, Finland.
    Abstract

    Many people report suffering from post-acute sequelae of COVID-19 or "long-COVID", but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18-99 years from 16 countries of Asia, Europe, North America and South America (May-Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.


    © 2022 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.

    KEYWORDS: COVID-19, excessive daytime sleepiness, fatigue, insomnia, pandemic, post-acute sequelae of COVID-19

    Publikations ID: 36208038
    Quelle: öffnen
     
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