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| Biomedicines. 2022 Apr 6. pii: biomedicines10040858. doi: 10.3390/biomedicines10040858 |
| COVID-19 Infection Induce miR-371a-3p Upregulation Resulting in Influence on Male Fertility. |
| Goebel H1, Koeditz B2, Huerta M3, Kameri E4, Nestler T5, Kamphausen T6, Friemann J7, Hamdorf M8, Ohrmann T9, Koehler P10, Cornely OA11, Montesinos-Rongen M12, Nicol D13, Schorle H14, Boor P15, Quaas A16, Pallasch C17, Heidenreich A18, von Brandenstein M19 |
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Abstract In December 2019, the first case of COVID-19 was reported and since then several groups have already published that the virus can be present in the testis. To study the influence of SARS-CoV-2 which cause a dysregulation of the androgen receptor (AR) level, thereby leading to fertility problems and inducing germ cell testicular changes in patients after the infection. Formalin-Fixed-Paraffin-Embedded (FFPE) testicular samples from patients who died with or as a result of COVID-19 ( = 32) with controls ( = 6), inflammatory changes ( = 9), seminoma with/without metastasis ( = 11) compared with healthy biopsy samples ( = 3) were analyzed and compared via qRT-PCR for the expression of miR-371a-3p. An immunohistochemical analysis (IHC) and ELISA were performed in order to highlight the miR-371a-3p targeting the AR. Serum samples of patients with mild or severe COVID-19 symptoms ( = 34) were analyzed for miR-371a-3p expression. In 70% of the analyzed postmortem testicular tissue samples, a significant upregulation of the miR-371a-3p was detected, and 75% of the samples showed a reduced spermatogenesis. In serum samples, the upregulation of the miR-371a-3p was also detectable. The upregulation of the miR-371a-3p is responsible for the downregulation of the AR in SARS-CoV-2-positive patients, resulting in decreased spermatogenesis. Since the dysregulation of the AR is associated with infertility, further studies have to confirm if the identified dysregulation is regressive after a declining infection. |
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KEYWORDS: COVID-19, SARS-CoV-2, androgen receptor, male infertility, miR-371a-3p |
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Publikations ID: 35453608 Quelle: öffnen |
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