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| Clinical practice and epidemiology in mental health : CP & EMH. 2021 Dec 31. doi: 10.2174/1745017902117010315. pii: CPEMH-17-315. pmc: PMC8985466 |
| The Quality of Life of People with Solid Cancer is Less Worse than Other Diseases with better Prognosis, Except in the Presence of Depression. |
| Aviles Gonzalez CI1, Angermeyer M2, Deiana L3, Loi C4, Murgia E5, Holzinger A6, Cossu G7, Massa E8, Romano F9, Scartozzi M10, Carta MG11 |
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Abstract BACKGROUND: Suffering from Solid Cancer (SC) may adversely impact the Health-related Quality of Life (H-QoL). The aims of this study are to measure the H-QoL in a sample of people suffering from SC and to clarify the role of the co-occurrence of depressive episodes. Results were compared with a healthy control group and with groups of other disorders. METHODS: In 151 patients with SC (mean±sd age 63.1±11.5; female 54.3%), H-QoL was assessed by SF-12, depressive episodes were identified by PHQ-9. The attributable burden of SC in impairing H-QoL was calculated as the difference between SF-12 score of a community sex and age ¼ matched healthy control group and that of the study sample. The attributable burden of SC was compared with other chronic diseases using specific diagnostic groups drawn from case-control studies that used the same database for selecting control samples. RESULTS: H-QoL in people with SC was significantly worse than in the healthy control group (p<0.0001). The attributable burden in worsening the H-QoL due to SC was similar to those of severe chronic diseases, but lower than Multiple Sclerosis (p<0.0001) or Fibromyalgia (p<0.00001). Having a depressive episode was a strong determinant of decreasing H-QoL, regardless of the severity of cancer. CONCLUSION: The findings confirm a strong impact of SC but showed that H-QoL in SC was higher than in chronic diseases with better "quoad vitam" outcome. Since depression was a strong determinant, its prevention, early detection and therapy are the main objectives that must be reached in cancer patients. |
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© 2021 Aviles Gonzalez et al. |
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KEYWORDS: Depression, Health-related quality of life, Oncology, Psychiatric comorbidity, Psycho-oncology, Psychosocial health |
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Publikations ID: 35444707 Quelle: öffnen |
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