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    Nature genetics. 2022 Apr 4. doi: 10.1038/s41588-022-01024-z. pii: 10.1038/s41588-022-01024-z
    New insights into the genetic etiology of Alzheimer's disease and related dementias.
    Bellenguez C1,  Küçükali F2,  Jansen IE3,  Kleineidam L4,  Moreno-Grau S5,  Amin N6,  Naj AC7,  Campos-Martin R8,  Grenier-Boley B9,  Andrade V10,  Holmans PA11,  Boland A12,  Damotte V13,  van der Lee SJ14,  Costa MR15,  Kuulasmaa T16,  Yang Q17,  de Rojas I18,  Bis JC19,  Yaqub A20,  Prokic I21,  Chapuis J22,  Ahmad S23,  Giedraitis V24,  Aarsland D25,  Garcia-Gonzalez P26,  Abdelnour C27,  Alarcón-Martín E28,  Alcolea D29,  Alegret M30,  Alvarez I31,  Álvarez V32,  Armstrong NJ33,  Tsolaki A34,  Antúnez C35,  Appollonio I36,  Arcaro M37,  Archetti S38,  Pastor AA39,  Arosio B40,  Athanasiu L41,  Bailly H42,  Banaj N43,  Baquero M44,  Barral S45,  Beiser A46,  Pastor AB47,  Below JE48,  Benchek P49,  Benussi L50,  Berr C51,  Besse C52,  Bessi V53,  Binetti G54,  Bizarro A55,  Blesa R56,  Boada M57,  Boerwinkle E58,  Borroni B59,  Boschi S60,  Bossù P61,  Bråthen G62,  Bressler J63,  Bresner C64,  Brodaty H65,  Brookes KJ66,  Brusco LI67,  Buiza-Rueda D68,  Bûrger K69,  Burholt V70,  Bush WS71,  Calero M72,  Cantwell LB73,  Chene G74,  Chung J75,  Cuccaro ML76,  Carracedo Á77,  Cecchetti R78,  Cervera-Carles L79,  Charbonnier C80,  Chen HH81,  Chillotti C82,  Ciccone S83,  Claassen JAHR84,  Clark C85,  Conti E86,  Corma-Gómez A87,  Costantini E88,  Custodero C89,  Daian D90,  Dalmasso MC91,  Daniele A92,  Dardiotis E93,  Dartigues JF94,  de Deyn PP95,  de Paiva Lopes K96,  de Witte LD97,  Debette S98,  Deckert J99,  Del Ser T100,  Denning N101,  DeStefano A102,  Dichgans M103,  Diehl-Schmid J104,  Diez-Fairen M105,  Rossi PD106,  Djurovic S107,  Duron E108,  Düzel E109,  Dufouil C110,  Eiriksdottir G111,  Engelborghs S112,  Escott-Price V113,  Espinosa A114,  Ewers M115,  Faber KM116,  Fabrizio T117,  Nielsen SF118,  Fardo DW119,  Farotti L120,  Fenoglio C121,  Fernández-Fuertes M122,  Ferrari R123,  Ferreira CB124,  Ferri E125,  Fin B126,  Fischer P127,  Fladby T128,  Fließbach K129,  Fongang B130,  Fornage M131,  Fortea J132,  Foroud TM133,  Fostinelli S134,  Fox NC135,  Franco-Macías E136,  Bullido MJ137,  Frank-García A138,  Froelich L139,  Fulton-Howard B140,  Galimberti D141,  García-Alberca JM142,  García-González P143,  Garcia-Madrona S144,  Garcia-Ribas G145,  Ghidoni R146,  Giegling I147,  Giorgio G148,  Goate AM149,  Goldhardt O150,  Gomez-Fonseca D151,  González-Pérez A152,  Graff C153,  Grande G154,  Green E155,  Grimmer T156,  Grünblatt E157,  Grunin M158,  Gudnason V159,  Guetta-Baranes T160,  Haapasalo A161,  Hadjigeorgiou G162,  Haines JL163,  Hamilton-Nelson KL164,  Hampel H165,  Hanon O166,  Hardy J167,  Hartmann AM168,  Hausner L169,  Harwood J170,  Heilmann-Heimbach S171,  Helisalmi S172,  Heneka MT173,  Hernández I174,  Herrmann MJ175,  Hoffmann P176,  Holmes C177,  Holstege H178,  Vilas RH179,  Hulsman M180,  Humphrey J181,  Biessels GJ182,  Jian X183,  Johansson C184,  Jun GR185,  Kastumata Y186,  Kauwe J187,  Kehoe PG188,  Kilander L189,  Ståhlbom AK190,  Kivipelto M191,  Koivisto A192,  Kornhuber J193,  Kosmidis MH194,  Kukull WA195,  Kuksa PP196,  Kunkle BW197,  Kuzma AB198,  Lage C199,  Laukka EJ200,  Launer L201,  Lauria A202,  Lee CY203,  Lehtisalo J204,  Lerch O205,  Lleó A206,  Longstreth W207,  Lopez O208,  de Munain AL209,  Love S210,  Löwemark M211,  Luckcuck L212,  Lunetta KL213,  Ma Y214,  Macías J215,  MacLeod CA216,  Maier W217,  Mangialasche F218,  Spallazzi M219,  Marquié M220,  Marshall R221,  Martin ER222,  Montes AM223,  Rodríguez CM224,  Masullo C225,  Mayeux R226,  Mead S227,  Mecocci P228,  Medina M229,  Meggy A230,  Mehrabian S231,  Mendoza S232,  Menéndez-González M233,  Mir P234,  Moebus S235,  Mol M236,  Molina-Porcel L237,  Montrreal L238,  Morelli L239,  Moreno F240,  Morgan K241,  Mosley T242,  Nöthen MM243,  Muchnik C244,  Mukherjee S245,  Nacmias B246,  Ngandu T247,  Nicolas G248,  Nordestgaard BG249,  Olaso R250,  Orellana A251,  Orsini M252,  Ortega G253,  Padovani A254,  Paolo C255,  Papenberg G256,  Parnetti L257,  Pasquier F258,  Pastor P259,  Peloso G260,  Pérez-Cordón A261,  Pérez-Tur J262,  Pericard P263,  Peters O264,  Pijnenburg YAL265,  Pineda JA266,  Piñol-Ripoll G267,  Pisanu C268,  Polak T269,  Popp J270,  Posthuma D271,  Priller J272,  Puerta R273,  Quenez O274,  Quintela I275,  Thomassen JQ276,  Rábano A277,  Rainero I278,  Rajabli F279,  Ramakers I280,  Real LM281,  Reinders MJT282,  Reitz C283,  Reyes-Dumeyer D284,  Ridge P285,  Riedel-Heller S286,  Riederer P287,  Roberto N288,  Rodriguez-Rodriguez E289,  Rongve A290,  Allende IR291,  Rosende-Roca M292,  Royo JL293,  Rubino E294,  Rujescu D295,  Sáez ME296,  Sakka P297,  Saltvedt I298,  Sanabria Á299,  Sánchez-Arjona MB300,  Sanchez-Garcia F301,  Juan PS302,  Sánchez-Valle R303,  Sando SB304,  Sarnowski C305,  Satizabal CL306,  Scamosci M307,  Scarmeas N308,  Scarpini E309,  Scheltens P310,  Scherbaum N311,  Scherer M312,  Schmid M313,  Schneider A314,  Schott JM315,  Selbæk G316,  Seripa D317,  Serrano M318,  Sha J319,  Shadrin AA320,  Skrobot O321,  Slifer S322,  Snijders GJL323,  Soininen H324,  Solfrizzi V325,  Solomon A326,  Song Y327,  Sorbi S328,  Sotolongo-Grau O329,  Spalletta G330,  Spottke A331,  Squassina A332,  Stordal E333,  Tartan JP334,  Tárraga L335,  Tesí N336,  Thalamuthu A337,  Thomas T338,  Tosto G339,  Traykov L340,  Tremolizzo L341,  Tybjærg-Hansen A342,  Uitterlinden A343,  Ullgren A344,  Ulstein I345,  Valero S346,  Valladares O347,  Broeckhoven CV348,  Vance J349,  Vardarajan BN350,  van der Lugt A351,  Dongen JV352,  van Rooij J353,  van Swieten J354,  Vandenberghe R355,  Verhey F356,  Vidal JS357,  Vogelgsang J358,  Vyhnalek M359,  Wagner M360,  Wallon D361,  Wang LS362,  Wang R363,  Weinhold L364,  Wiltfang J365,  Windle G366,  Woods B367,  Yannakoulia M368,  Zare H369,  Zhao Y370,  Zhang X371,  Zhu C372,  Zulaica M373,  Farrer LA374,  Psaty BM375,  Ghanbari M376,  Raj T377,  Sachdev P378,  Mather K379,  Jessen F380,  Ikram MA381,  de Mendonça A382,  Hort J383,  Tsolaki M384,  Pericak-Vance MA385,  Amouyel P386,  Williams J387,  Frikke-Schmidt R388,  Clarimon J389,  Deleuze JF390,  Rossi G391,  Seshadri S392,  Andreassen OA393,  Ingelsson M394,  Hiltunen M395,  Sleegers K396,  Schellenberg GD397,  van Duijn CM398,  Sims R399,  van der Flier WM400,  Ruiz A401,  Ramirez A402,  Lambert JC403
    Collaborators
    Laczo J Matoska V Serpente M Assogna F Piras F Piras F Ciullo V Shofany J Ferrarese C Andreoni S Sala G Zoia CP Zompo MD Benussi A Bastiani P Takalo M Natunen T Laatikainen T Tuomilehto J Antikainen R Strandberg T Lindström J Peltonen M Abraham R Al-Chalabi A Bass NJ Brayne C Brown KS Collinge J Craig D Deloukas P Fox N Gerrish A Gill M Gwilliam R Harold D Hollingworth P Johnston JA Jones L Lawlor B Livingston G Lovestone S Lupton M Lynch A Mann D McGuinness B McQuillin A O'Donovan MC Owen MJ Passmore P Powell JF Proitsi P Rossor M Shaw CE Smith AD Gurling H Todd S Mummery C Ryan N Lacidogna G Adarmes-Gómez A Mauleón A Pancho A Gailhajenet A Lafuente A Macias-García D Martín E Pelejà E Carrillo F Merlín IS Garrote-Espina L Vargas L Carrion-Claro M Marín M Labrador M Buendia M Alonso MD Guitart M Moreno M Ibarria M Periñán M Aguilera N Gómez-Garre P Cañabate P Escuela R Pineda-Sánchez R Vigo-Ortega R Jesús S Preckler S Rodrigo-Herrero S Diego S Vacca A Roveta F Salvadori N Chipi E Boecker H Laske C Perneczky R Anastasiou C Janowitz D Malik R Anastasiou A Parveen K Lage C López-García S Antonell A Mihova KY Belezhanska D Weber H Kochen S Solis P Medel N Lisso J Sevillano Z Politis DG Cores V Cuesta C Ortiz C Bacha JI Rios M Saenz A Abalos MS Kohler E Palacio DL Etchepareborda I Kohler M Novack G Prestia FA Galeano P Castaño EM Germani S Toso CR Rojo M Ingino C Mangone C Rubinsztein DC Teipel S Fievet N Deramerourt V Forsell C Thonberg H Bjerke M Roeck E Martínez-Larrad MT Olivar N Aguilera N Cano A Cañabate P Macias J Maroñas O Nuñez-Llaves R Olivé C Pelejá E Adarmes-Gómez AD Alonso MD Amer-Ferrer G Antequera M Burguera JA Carrillo F Carrión-Claro M Casajeros MJ Martinez de Pancorbo M Escuela R Garrote-Espina L Gómez-Garre P Hevilla S Jesús S Espinosa MAL Legaz A López-García S Macias-García D Manzanares S Marín M Marín-Muñoz J Marín T Martínez B Martínez V Martínez-Lage Álvarez P Iriarte MM Periñán-Tocino MT Pineda-Sánchez R Real de Asúa D Rodrigo S Sastre I Vicente MP Vigo-Ortega R Vivancos L Epelbaum J Hannequin D Campion D Deramecourt V Tzourio C Brice A Dubois B Williams A Thomas C Davies C Nash W Dowzell K Morales AC Bernardo-Harrington M Turton J Lord J Brown K Vardy E Fisher E Warren JD Rossor M Ryan NS Guerreiro R Uphill J Bass N Heun R Kölsch H Schürmann B Lacour A Herold C Johnston JA Passmore P Powell J Patel Y Hodges A Becker T Warden D Wilcock G Clarke R Deloukas P Ben-Shlomo Y Hooper NM Pickering-Brown S Sussams R Warner N Bayer A Heuser I Drichel D Klopp N Mayhaus M Riemenschneider M Pinchler S Feulner T Gu W van den Bussche H Hüll M Frölich L Wichmann HE Jöckel KH O'Donovan M Owen M Bahrami S Bosnes I Selnes P Bergh S Palotie A Daly M Jacob H Matakidou A Runz H John S Plenge R McCarthy M Hunkapiller J Ehm M Waterworth D Fox C Malarstig A Klinger K Call K Behrens T Loerch P Mäkelä T Kaprio J Virolainen P Pulkki K Kilpi T Perola M Partanen J Pitkäranta A Kaarteenaho R Vainio S Turpeinen M Serpi R Laitinen T Mäkelä J Kosma VM Kujala U Tuovila O Hendolin M Pakkanen R Waring J Riley-Gillis B Liu J Biswas S Diogo D Marshall C Hu X Gossel M Graham R Cummings B Ripatti S Schleutker J Arvas M Carpén O Hinttala R Kettunen J Mannermaa A Laukkanen J Julkunen V Remes A Kälviäinen R Peltola J Tienari P Rinne J Ziemann A Waring J Esmaeeli S Smaoui N Lehtonen A Eaton S Lahdenperä S van Adelsberg J Michon J Kerchner G Bowers N Teng E Eicher J Mehta V Gormley P Linden K Whelan C Xu F Pulford D Färkkilä M Pikkarainen S Jussila A Blomster T Kiviniemi M Voutilainen M Georgantas B Heap G Rahimov F Usiskin K Lu T Oh D Kalpala K Miller M McCarthy L Eklund K Palomäki A Isomäki P Pirilä L Kaipiainen-Seppänen O Huhtakangas J Lertratanakul A Hochfeld M Bing N Gordillo JE Mars N Pelkonen M Kauppi P Kankaanranta H Harju T Close D Greenberg S Chen H Betts J Ghosh S Salomaa V Niiranen T Juonala M Metsärinne K Kähönen M Junttila J Laakso M Pihlajamäki J Sinisalo J Taskinen MR Tuomi T Challis B Peterson A Chu A Parkkinen J Muslin A Joensuu H Meretoja T Aaltonen L Mattson J Auranen A Karihtala P Kauppila S Auvinen P Elenius K Popovic R Schutzman J Loboda A Chhibber A Lehtonen H McDonough S Crohns M Kulkarni D Kaarniranta K Turunen JA Ollila T Seitsonen S Uusitalo H Aaltonen V Uusitalo-Järvinen H Luodonpää M Hautala N Loomis S Strauss E Chen H Podgornaia A Hoffman J Tasanen K Huilaja L Hannula-Jouppi K Salmi T Peltonen S Koulu L Harvima I Wu Y Choy D Pussinen P Salminen A Salo T Rice D Nieminen P Palotie U Siponen M Suominen L Mäntylä P Gursoy U Anttonen V Sipilä K Davis JW Quarless D Petrovski S Wigmore E Chen CY Bronson P Tsai E Huang Y Maranville J Shaikho E Mohammed E Wadhawan S Kvikstad E Caliskan M Chang D Bhangale T Pendergrass S Holzinger E Chen X Hedman Å King KS Wang C Xu E Auge F Chatelain C Rajpal D Liu D Call K Xia TH Brauer M Kurki M Karjalainen J Havulinna A Jalanko A Palta P Della Briotta Parolo P Zhou W Lemmelä S Rivas M Harju J Lehisto A Ganna A Llorens V Laivuori H Rüeger S Niemi ME Tukiainen T Reeve MP Heyne H Palin K Garcia-Tabuenca J Siirtola H Kiiskinen T Lee J Tsuo K Elliott A Kristiansson K Hyvärinen K Ritari J Koskinen M Pylkäs K Kalaoja M Karjalainen M Mantere T Kangasniemi E Heikkinen S Laakkonen E Sipeky C Heron S Karlsson A Jambulingam D Rathinakannan VS Kajanne R Aavikko M Jiménez MG Della Briotta Parola P Lehistö A Kanai M Kaunisto M Kilpeläinen E Sipilä TP Brein G Awaisa G Shcherban A Donner K Loukola A Laiho P Sistonen T Kaiharju E Laukkanen M Järvensivu E Lähteenmäki S Männikkö L Wong R Mattsson H Hiekkalinna T Paajanen T Pärn K Gracia-Tabuenca J Abner E Adams PM Aguirre A Albert MS Albin RL Allen M Alvarez L Apostolova LG Arnold SE Asthana S Atwood CS Ayres G Baldwin CT Barber RC Barnes LL Barral S Beach TG Becker JT Beecham GW Beekly D Below JE Benchek P Benitez BA Bennett D Bertelson J Margaret FE Bird TD Blacker D Boeve BF Bowen JD Boxer A Brewer J Burke JR Burns JM Bush WS Buxbaum JD Cairns NJ Cao C Carlson CS Carlsson CM Carney RM Carrasquillo MM Chasse S Chesselet MF Chesi A Chin NA Chui HC Chung J Craft S Crane PK Cribbs DH Crocco EA Cruchaga C Cuccaro ML Cullum M Darby E Davis B De Jager PL DeCarli C DeToledo J Dick M Dickson DW Dombroski BA Doody RS Duara R Ertekin-Taner N Evans DA Fairchild TJ Fallon KB Farlow MR Farrell JJ Fernandez-Hernandez V Ferris S Frosch MP Fulton-Howard B Galasko DR Gamboa A Gearing M Geschwind DH Ghetti B Gilbert JR Grabowski TJ Graff-Radford NR Grant SFA Green RC Growdon JH Haines JL Hakonarson H Hall J Hamilton RL Harari O Harrell LE Haut J Head E Henderson VW Hernandez M Hohman T Honig LS Huebinger RM Huentelman MJ Hulette CM Hyman BT Hynan LS Ibanez L Jarvik GP Jayadev S Jin LW Johnson K Johnson L Kamboh MI Karydas AM Katz MJ Kaye JA Keene CD Khaleeq A Kim R Knebl J Kowall NW Kramer JH Kuksa PP LaFerla FM Lah JJ Larson EB Lee CY Lee EB Lerner A Leung YY Leverenz JB Levey AI Li M Lieberman AP Lipton RB Logue M Lyketsos CG Malamon J Mains D Marson DC Martiniuk F Mash DC Masliah E Massman P Masurkar A McCormick WC McCurry SM McDavid AN McDonough S McKee AC Mesulam M Mez J Miller BL Miller CA Miller JW Montine TJ Monuki ES Morris JC Myers AJ Nguyen T O'Bryant S Olichney JM Ory M Palmer R Parisi JE Paulson HL Pavlik V Paydarfar D Perez V Peskind E Petersen RC Phillips-Cremins JE Pierce A Polk M Poon WW Potter H Qu L Quiceno M Quinn JF Raj A Raskind M Reiman EM Reisberg B Reisch JS Ringman JM Roberson ED Rodriguear M Rogaeva E Rosen HJ Rosenberg RN Royall DR Sager MA Sano M Saykin AJ Schneider JA Schneider LS Seeley WW Slifer SH Small S Smith AG Smith JP Song YE Sonnen JA Spina S George-Hyslop PS Stern RA Stevens AB Strittmatter SM Sultzer D Swerdlow RH Tanzi RE Tilson JL Trojanowski JQ Troncoso JC Tsuang DW Valladares O Van Deerlin VM van Eldik LJ Vassar R Vinters HV Vonsattel JP Weintraub S Welsh-Bohmer KA Whitehead PL Wijsman EM Wilhelmsen KC Williams B Williamson J Wilms H Wingo TS Wisniewski T Woltjer RL Woon M Wright CB Wu CK Younkin SG Yu CE Yu L Zhang Y Zhao Y Zhu X Adams H Akinyemi RO Ali M Armstrong N Aparicio HJ Bahadori M Becker JT Breteler M Chasman D Chauhan G Comic H Cox S Cupples AL Davies G DeCarli CS Duperron MG Dupuis J Evans T Fan F Fitzpatrick A Fohner AE Ganguli M Geerlings M Glatt SJ Gonzalez HM Goss M Grabe H Habes M Heckbert SR Hofer E Hong E Hughes T Kautz TF Knol M Kremen W Lacaze P Lahti J Grand QL Litkowski E Li S Liu D Liu X Loitfelder M Manning A Maillard P Marioni R Mazoyer B van Lent DM Mei H Mishra A Nyquist P O'Connell J Patel Y Paus T Pausova Z Raikkonen-Talvitie K Riaz M Rich S Rotter J Romero J Roshchupkin G Saba Y Sargurupremraj M Schmidt H Schmidt R Shulman JM Smith J Sekhar H Rajula R Shin J Simino J Sliz E Teumer A Thomas A Tin A Tucker-Drob E Vojinovic D Wang Y Weinstein G Williams D Wittfeld K Yanek L Yang Y
    Author information
    1Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. celine.bellenguez@pasteur-lille.fr.
    2Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
    3Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    4Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    5Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    6Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
    7Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    8Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
    9Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
    10Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    11MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
    12CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
    13Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
    14Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    15Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
    16Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
    17Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
    18Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    19Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
    20Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
    21Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
    22Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
    23Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
    24Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
    25Centre of Age-Related Medicine, Stavanger University Hospital, Stavanger, Norway.
    26Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    27Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    28Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    29CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    30Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    31Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.
    32Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.
    33Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
    34First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    35Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
    36School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
    37Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.
    38Department of Laboratory Diagnostics, III Laboratory of Analysis, Brescia Hospital, Brescia, Italy.
    39Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
    40Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
    41NORMENT Centre, University of Oslo, Oslo, Norway.
    42EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
    43Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
    44Servei de Neurologia, Hospital Universitari i Politècnic La Fe, Valencia, Spain.
    45Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
    46Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
    47CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
    48Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
    49Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, OH, USA.
    50Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
    51Neuropsychiatry: Epidemiological and Clinical Research, PSNREC, Université de Montpellier, INSERM U1061, Montpellier, France.
    52CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
    53Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
    54Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
    55Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
    56CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    57Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    58Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
    59Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
    60Department of Neuroscience "Rita Levi Montalcini", University of Torino, Torino, Italy.
    61Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
    62Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
    63Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
    64MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
    65Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
    66Biosciences, School of Science and Technology, Nottingham Trent University, Nottingham, UK.
    67Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.
    68CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    69Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.
    70Faculty of Medical & Health Sciences, University of Auckland, Auckland, New Zealand.
    71Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
    72Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    73Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    74INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.
    75Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.
    76Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
    77Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
    78Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
    79CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    80Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
    81Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.
    82Unit of Clinical Pharmacology, University Hospital of Cagliari, Cagliari, Italy.
    83Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
    84Radboudumc Alzheimer Center, Department of Geriatrics, Radboud University Medical Center, Nijmegen, the Netherlands.
    85Institute for Regenerative Medicine, University of Zürich, Schlieren, Switzerland.
    86School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
    87Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
    88Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
    89University of Bari, "A. Moro", Bary, Italy.
    90CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
    91Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
    92Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
    93School of Medicine, University of Thessaly, Larissa, Greece.
    94Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France.
    95Department of Neurology, University Medical Center Groningen, Groningen, the Netherlands.
    96Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    97Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    98Bordeaux Population Health Research Center, University Bordeaux, INSERM, Bordeaux, France.
    99Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
    100CIEN Foundation/Queen Sofia Foundation Alzheimer Center, Madrid, Spain.
    101UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
    102Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
    103Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.
    104Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
    105Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.
    106Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
    107NORMENT Centre, University of Oslo, Oslo, Norway.
    108EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
    109Institute of Cognitive Neurology and Dementia Research (IKND), Otto-Von-Guericke University, Magdeburg, Germany.
    110INSERM, Bordeaux Population Health Research Center, UMR 1219, ISPED, CIC 1401-EC, Université de Bordeaux, Bordeaux, France.
    111Icelandic Heart Association, Kopovagur, Iceland.
    112Center for Neurosciences, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
    113Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    114Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    115Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilians Universität (LMU), Munich, Germany.
    116Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
    117Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
    118Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.
    119Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, KY, USA.
    120Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
    121University of Milan, Milan, Italy.
    122Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
    123Laboratory of Neurogenetics, Department of Internal Medicine, Texas Tech University Health Science Center, Lubbock, TX, USA.
    124Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
    125Geriatic Unit, Fondazione Cà Granda, IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
    126CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
    127Department of Psychiatry, Social Medicine Center East- Donauspital, Vienna, Austria.
    128Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    129Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany.
    130Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
    131Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
    132CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    133Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA.
    134Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
    135Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
    136Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
    137CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    138CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    139Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany.
    140Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    141Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.
    142CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    143Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    144Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
    145Hospital Universitario Ramon y Cajal, IRYCIS, Madrid, Spain.
    146Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
    147Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
    148Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
    149Department of Genetics and Genomic Sciences, Ronald M. Loeb Center for Alzheimer's Disease Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    150Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
    151Department of Biostatistics, Epidemiology, and Informatics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    152CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.
    153Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
    154Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    155Institute of Public Health, University of Cambridge, Cambridge, UK.
    156Klinikum rechts der Isar, Department of Psychiatry and Psychotherapy, Technical University of Munich, School of Medicine, Munich, Germany.
    157Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland.
    158Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
    159Icelandic Heart Association, Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    160Human Genetics, School of Life Sciences, Life Sciences Building, University Park, University of Nottingham, Nottingham, UK.
    161AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    162Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
    163Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
    164The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
    165GRC 21, Alzheimer Precision Medicine Initiative (APMI), Sorbonne University, AP-HP, Pitié-Salpêtrière Hospital, Paris, France.
    166EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
    167Reta Lila Weston Research Laboratories, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
    168Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
    169Department of Geriatric Psychiatry, Central Institute for Mental Health, Mannheim, University of Heidelberg, Heidelberg, Germany.
    170MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
    171Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
    172Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
    173Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    174Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    175Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
    176Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
    177Clinical and Experimental Science, Faculty of Medicine, University of Southampton, Southampton, UK.
    178Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    179Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
    180Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    181Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    182Department of Neurology, UMC Utrecht Brain Center, Utrecht, the Netherlands.
    183Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
    184Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
    185Medicine Biomedical Genetics Boston University School of Medicine, Boston, MA, USA.
    186Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA.
    187Department of Biology, Brigham Young University, Provo, UT, USA.
    188Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
    189Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
    190Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
    191Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
    192Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
    193Department of Psychiatry and Psychotherapy, Universitätsklinikum Erlangen, and Friedrich-Alexander Universität Erlangen-Nürnberg, Erlangen, Germany.
    194Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    195Department of Epidemiology, University of Washington, Seattle, WA, USA.
    196Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    197Department of Neurology, Medical School, University of Cyprus, Nicosia, Cyprus.
    198Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    199CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    200Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    201Laboratory of Epidemiology, Demography, and Biometry, National Institute of Aging, The National Institutes of Health, Bethesda, MD, USA.
    202Geriatrics Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
    203Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    204Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
    205Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.
    206CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    207Departments of Neurology and Epidemiology, University of Washington, Seattle, WA, USA.
    208Framingham Heart Study, Framingham, MA, USA.
    209CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    210Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
    211Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
    212MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
    213Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
    214Section Genomics of Neurodegenerative Diseases and Aging, Department of Human Genetics Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    215Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
    216School of Health Sciences, Bangor University, Bangor, UK.
    217Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    218Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden.
    219Unit of Neurology, University of Parma and AOU, Parma, Italy.
    220Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    221MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
    222The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
    223CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    224Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.
    225Institute of Neurology, Catholic University of the Sacred Heart, Rome, Italy.
    226Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
    227MRC Prion Unit at UCL, UCL Institute of Prion Diseases, London, UK.
    228Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
    229CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    230UKDRI@ Cardiff, School of Medicine, Cardiff University, Cardiff, UK.
    231Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.
    232Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain.
    233Servicio de Neurología, Hospital Universitario Central de Asturias- Oviedo and Instituto de Investigación Biosanitaria del Principado de Asturias, Oviedo, Spain.
    234CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    235Institute for Urban Public Health, University Hospital of University Duisburg-Essen, Essen, Germany.
    236Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
    237Neurological Tissue Bank of the Biobanc-Hospital Clinic-IDIBAPS, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
    238Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    239Laboratory of Brain Aging and Neurodegeneration, FIL-CONICET, Buenos Aires, Argentina.
    240CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    241Human Genetics, School of Life Sciences, University of Nottingham, Nottingham, UK.
    242Memory Impairment and Neurodegenerative Dementia (MIND) Center, University of Mississippi Medical Center, Jackson, MS, USA.
    243Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany.
    244Centro de Neuropsiquiatría y Neurología de la Conducta (CENECON), Facultad de Medicina, Universidad de Buenos Aires (UBA), C.A.B.A., Buenos Aires, Argentina.
    245Department of Medicine, University of Washington, Seattle, WA, USA.
    246Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
    247Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
    248Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
    249Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev, Denmark.
    250CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
    251Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    252Department of Neuroscience, Catholic University of Sacred Heart, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
    253Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    254Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
    255DIMEC, University of Parma, Parma, Italy.
    256Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
    257Centre for Memory Disturbances, Lab of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy.
    258Resources and Research Memory Center (MRRC) of Distalz, LicendUniversity of Lille, INSERM, CHU Lille, UMR1172, Lille, France.
    259Fundació Docència i Recerca MútuaTerrassa and Movement Disorders Unit, Department of Neurology, University Hospital MútuaTerrassa, Terrassa, Spain.
    260Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
    261Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    262CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    263US 41-UMS 2014-PLBS, bilille, Université de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, Lille, France.
    264Institute of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Berlin, Germany.
    265Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    266Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
    267Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Lleida, Spain.
    268Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
    269Department of Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital, Wuerzburg, Germany.
    270CHUV, Old Age Psychiatry, Department of Psychiatry, Lausanne, Switzerland.
    271Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije University, Amsterdam, the Netherlands.
    272German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
    273Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    274Department of Genetics and CNR-MAJ, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
    275Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
    276Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark.
    277CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    278Centre for Neurodegenerative Disorders, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
    279The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
    280Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
    281Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario de Valme, Sevilla, Spain.
    282Delft Bioinformatics Lab, Delft University of Technology, Delft, the Netherlands.
    283Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA.
    284Department of Neurology, Columbia University, New York, NY, USA.
    285Bioinformatics, College of Life Sciences, Brigham Young University, Provo, UT, USA.
    286Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
    287Center of Mental Health, Clinic and Policlinic of Psychiatry, Psychosomatics and Psychotherapy, University Hospital of Würzburg, Wuerzburg, Germany.
    288Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    289CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    290Department of Research and Innovation, Helse Fonna, Haugesund Hospital, Haugesund, Norway.
    291Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.
    292Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    293Departamento de Especialidades Quirúrgicas, Bioquímicas e Inmunología, School of Medicine, University of Málaga, Málaga, Spain.
    294Department of Neuroscience and Mental Health, AOU Città della Salute e della Scienza di Torino, Torino, Italy.
    295Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
    296CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain.
    297Athens Association of Alzheimer's Disease and Related Disorders, Athens, Greece.
    298Department of Neurology and Clinical Neurophysiology, University Hospital of Trondheim, Trondheim, Norway.
    299Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    300Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
    301Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Las Palmas, Spain.
    302CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    303Neurology Department-Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain.
    304Experimental Neuro-psychobiology Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
    305Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
    306Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
    307Institute of Gerontology and Geriatrics, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
    308Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
    309Fondazione IRCCS Ca'Granda, Ospedale Policlinico, Milan, Italy.
    310Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    311LVR-Hospital Essen, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Duisburg-Essen, Essen, Germany.
    312Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
    313German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
    314Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    315Dementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
    316Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    317Laboratory for Advanced Hematological Diagnostics, Department of Hematology and Stem Cell Transplant, Vito Fazzi Hospital, Lecce, Italy.
    318Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Hospital Clínico San Carlos, Madrid, Spain.
    319Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    320NORMENT Centre, University of Oslo, Oslo, Norway.
    321Translational Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
    322The John P. Hussman Institute for Human Genomics, University of Miami, Miami, FL, USA.
    323Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    324Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
    325University of Bari, "A. Moro", Bary, Italy.
    326Institute of Clinical Medicine, Neurology, University of Eastern, Kuopio, Finland.
    327Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.
    328Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy.
    329Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    330Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy.
    331German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.
    332Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, Cagliari, Italy.
    333Department of Psychiatry, Namsos Hospital, Namsos, Norway.
    334Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    335Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    336Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    337Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
    338First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    339Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
    340Clinic of Neurology, UH 'Alexandrovska', Medical University - Sofia, Sofia, Bulgaria.
    341School of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
    342Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
    343Department of Internal Medicine and Biostatistics, Erasmus MC, Rotterdam, the Netherlands.
    344Center for Alzheimer Research, Department NVS, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
    345Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
    346Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    347Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    348Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
    349Dr. John T. Macdonald Foundation Department of Human Genetics, University of Miami, Miami, FL, USA.
    350Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA.
    351Department of Neurology, ErasmusMC, Rotterdam, the Netherlands.
    352Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
    353Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
    354Department of Neurology, Erasmus MC, Rotterdam, the Netherlands.
    355Laboratory for Cognitive Neurology, Department of Neurosciences, University of Leuven, Leuven, Belgium.
    356Department of Psychiatry & Neuropsychologie, Maastricht University, Alzheimer Center Limburg, Maastricht, the Netherlands.
    357EA 4468, Université de Paris, APHP, Hôpital Broca, Paris, France.
    358Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
    359Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Praha, Czechia.
    360Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    361Department of Neurology and CNR-MAJ, F 76000, Normandy Center for Genomic and Personalized Medicine, Normandie University, UNIROUEN, INSERM U1245, CHU Rouen, Rouen, France.
    362Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    363Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
    364Institute of Medical Biometry, Informatics and Epidemiology, University Hospital of Bonn, Bonn, Germany.
    365Department of Psychiatry and Psychotherapy, University Medical Center Goettingen, Goettingen, Germany.
    366School of Health Sciences, Bangor University, Bangor, UK.
    367School of Health Sciences, Bangor University, Bangor, UK.
    368Department of Nutrition and Diatetics, Harokopio University, Athens, Greece.
    369Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.
    370Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    371Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
    372Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, MA, USA.
    373CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    374Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
    375Framingham Heart Study, Framingham, MA, USA.
    376Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
    377Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    378Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
    379Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
    380Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    381Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
    382Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
    383Intramural Research Program/National Institute on Aging/National Institutes of Health, Bethesda, MD, USA.
    384First Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece.
    385AI Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
    386Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France.
    387MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
    388Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
    389CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain.
    390CEA, Centre National de Recherche en Génomique Humaine, Université Paris-Saclay, Evry, France.
    391Fondazione IRCCS, Istituto Neurologico Carlo Besta, Milan, Italy.
    392Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
    393NORMENT Centre, University of Oslo, Oslo, Norway.
    394Department of Public Health and Carins Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
    395Brain Institute, Federal University of Rio Grande do Norte, Natal, Brazil.
    396Complex Genetics of Alzheimer's Disease Group, VIB Center for Molecular Neurology, VIB, Antwerp, Belgium.
    397Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
    398Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands.
    399MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK.
    400Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands.
    401Research Center and Memory Clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain.
    402Department of Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany.
    403Université de Lille, INSERM, CHU Lille, Institut Pasteur Lille, U1167-RID-AGE, Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Jean-Charles.Lambert@pasteur-lille.fr.
    Abstract

    Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele.


    © 2022. The Author(s).

    Publikations ID: 35379992
    Quelle: öffnen
     
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