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| Matrix biology : journal of the International Society for Matrix Biology. 2022 Mar 9. pii: S0945-053X(22)00033-6. doi: 10.1016/j.matbio.2022.03.001 |
| Schwann cells contribute to keloid formation. |
| Direder M1, Weiss T2, Copic D3, Vorstandlechner V4, Laggner M5, Pfisterer K6, Mildner CS7, Klas K8, Bormann D9, Haslik W10, Radtke C11, Farlik M12, Shaw L13, Golabi B14, Tschachler E15, Hoetzenecker K16, Ankersmit HJ17, Mildner M18 |
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Abstract Keloids are disfiguring, hypertrophic scars with yet poorly understood pathomechanisms, which could lead to severe functional impairments. Here we analyzed the characteristics of keloidal cells by single cell sequencing and discovered the presence of an abundant population of Schwann cells that persisted in the hypertrophic scar tissue after wound healing. In contrast to normal skin, keloidal Schwann cells show a unique, pro-fibrotic phenotype. Our data support the hypothesis that keloidal Schwann cells contribute to the formation of the extracellular matrix and are able to affect M2 polarization of macrophages. Indeed, we show that macrophages in keloids predominantly display a M2 polarization and produce factors that inhibit Schwann cell differentiation. This study suggests the contribution of a Schwann cell - macrophage cross-talk to the continuous expansion of keloids, and that targeting Schwann cells might represent an interesting novel treatment option for keloids. |
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Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved. |
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KEYWORDS: Extracellular matrix, Keloid, Macrophage, Schwann cell, Single-cell RNA sequencing |
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Publikations ID: 35278628 Quelle: öffnen |
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