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    RSC medicinal chemistry. 2021 Dec 3. doi: 10.1039/d1md00228g. pii: d1md00228g. pmc: PMC8792830
    Target 2035 - update on the quest for a probe for every protein.
    Müller S1,  Ackloo S2,  Al Chawaf A3,  Al-Lazikani B4,  Antolin A5,  Baell JB6,  Beck H7,  Beedie S8,  Betz UAK9,  Bezerra GA10,  Brennan PE11,  Brown D12,  Brown PJ13,  Bullock AN14,  Carter AJ15,  Chaikuad A16,  Chaineau M17,  Ciulli A18,  Collins I19,  Dreher J20,  Drewry D21,  Edfeldt K22,  Edwards AM23,  Egner U24,  Frye SV25,  Fuchs SM26,  Hall MD27,  Hartung IV28,  Hillisch A29,  Hitchcock SH30,  Homan E31,  Kannan N32,  Kiefer JR33,  Knapp S34,  Kostic M35,  Kubicek S36,  Leach AR37,  Lindemann S38,  Marsden BD39,  Matsui H40,  Meier JL41,  Merk D42,  Michel M43,  Morgan MR44,  Mueller-Fahrnow A45,  Owen DR46,  Perry BG47,  Rosenberg SH48,  Saikatendu KS49,  Schapira M50,  Scholten C51,  Sharma S52,  Simeonov A53,  Sundström M54,  Superti-Furga G55,  Todd MH56,  Tredup C57,  Vedadi M58,  von Delft F59,  Willson TM60,  Winter GE61,  Workman P62,  Arrowsmith CH63
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    Abstract

    Twenty years after the publication of the first draft of the human genome, our knowledge of the human proteome is still fragmented. The challenge of translating the wealth of new knowledge from genomics into new medicines is that proteins, and not genes, are the primary executers of biological function. Therefore, much of how biology works in health and disease must be understood through the lens of protein function. Accordingly, a subset of human proteins has been at the heart of research interests of scientists over the centuries, and we have accumulated varying degrees of knowledge about approximately 65% of the human proteome. Nevertheless, a large proportion of proteins in the human proteome (∼35%) remains uncharacterized, and less than 5% of the human proteome has been successfully targeted for drug discovery. This highlights the profound disconnect between our abilities to obtain genetic information and subsequent development of effective medicines. Target 2035 is an international federation of biomedical scientists from the public and private sectors, which aims to address this gap by developing and applying new technologies to create by year 2035 chemogenomic libraries, chemical probes, and/or biological probes for the entire human proteome.


    This journal is © The Royal Society of Chemistry.

    Publikations ID: 35211674
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