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| HGG advances. 2020 Aug 25. doi: 10.1016/j.xhgg.2020.100010. pii: S2666-2477(20)30010-5. pmc: PMC8756515 |
| Hemochromatosis risk genotype is not associated with colorectal cancer or age at its diagnosis. |
| Jarvik GP1, Wang X2, Fontanillas P3, Kim E4, Chanprasert S5, Gordon AS6, Bastarache L7, Kowdley KV8, Harrison T9, Rosenthal EA10, Stanaway IB11, Bézieau S12, Weinstein SJ13, Newcomb PA14, Casey G15, Platz EA16, Visvanathan K17, Le Marchand L18, Ulrich CM19, Hardikar S20, Li CI21, van Duijnhoven FJB22, Gsur A23, Campbell PT24, Moreno V25, Vodička P26, Brenner H27, Chang-Claude J28, Hoffmeister M29, Slattery ML30, Gunter MJ31, Aglago EK32, Castellví-Bel S33, Kweon SS34, Chan AT35, Li L36, Zheng W37, Bishop DT38, Giles GG39, Rennert G40, Offit K41, Keku TO42, Woods MO43, Hampe J44, Van Guelpen B45, Gallinger SJ46, de la Chapelle A47, Hampel H48, Berndt SI49, Tangen CM50, Lindblom A51, Wolk A52, Burnett-Hartman A53, Wu AH54, White E55, Gruber SB56, Jenkins MA57, Mountain J58, Peters U59, Crosslin DR60 |
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Abstract Homozygotes for the higher penetrance hemochromatosis risk allele, c.845G>A (p.Cys282Tyr, or C282Y), have been reported to be at a 2- to 3-fold increased risk for colorectal cancer (CRC). These results have been reported for small sample size studies with no information about age at diagnosis for CRC. An association with age at diagnosis might alter CRC screening recommendations. We analyzed two large European ancestry datasets to assess the association of genotype with CRC risk and age at CRC diagnosis. The first dataset included 59,733 CRC or advanced adenoma cases and 72,351 controls from a CRC epidemiological study consortium. The second dataset included 13,564 self-reported CRC cases and 2,880,218 controls from the personal genetics company, 23andMe. No association of the common hereditary hemochromatosis (HH) risk genotype and CRC was found in either dataset. The odds ratios (ORs) for the association of CRC and C282Y homozygosity were 1.08 (95% confidence interval [CI], 0.91-1.29; p = 0.4) and 1.01 (95% CI, 0.78-1.31, p = 0.9) in the two cohorts, respectively. Age at CRC diagnosis also did not differ by C282Y/C282Y genotype in either dataset. These results indicate no increased CRC risk in individuals with HH genotypes and suggest that persons with HH risk genotypes can follow population screening recommendations for CRC. |
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© 2020 The Authors. |
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KEYWORDS: HFE gene, age of onset, colon cancer, ferritin, genetic, iron, population screening |
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Publikations ID: 35047832 Quelle: öffnen |
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