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| Frontiers in veterinary science. 2021 Dec 10. doi: 10.3389/fvets.2021.755258. pmc: PMC8702826 |
| Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal. |
| Willmann M1, Yuzbasiyan-Gurkan V2, Marconato L3, Dacasto M4, Hadzijusufovic E5, Hermine O6, Sadovnik I7, Gamperl S8, Schneeweiss-Gleixner M9, Gleixner KV10, Böhm T11, Peter B12, Eisenwort G13, Moriggl R14, Li Z15, Jawhar M16, Sotlar K17, Jensen-Jarolim E18, Sexl V19, Horny HP20, Galli SJ21, Arock M22, Vail DM23, Kiupel M24, Valent P25 |
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Abstract Mast cell neoplasms are one of the most frequently diagnosed malignancies in dogs. The clinical picture, course, and prognosis vary substantially among patients, depending on the anatomic site, grade and stage of the disease. The most frequently involved organ is the skin, followed by hematopoietic organs (lymph nodes, spleen, liver, and bone marrow) and mucosal sites of the oral cavity and the gastrointestinal tract. In cutaneous mast cell tumors, several grading and staging systems have been introduced. However, no comprehensive classification and no widely accepted diagnostic criteria have been proposed to date. To address these open issues and points we organized a Working Conference on canine mast cell neoplasms in Vienna in 2019. The outcomes of this meeting are summarized in this article. The proposed classification includes cutaneous mast cell tumors and their sub-variants defined by grading- and staging results, mucosal mast cell tumors, extracutaneous/extramucosal mast cell tumors without skin involvement, and mast cell leukemia (MCL). For each of these entities, diagnostic criteria are proposed. Moreover, we have refined grading and staging criteria for mast cell neoplasms in dogs based on consensus discussion. The criteria and classification proposed in this article should greatly facilitate diagnostic evaluation and prognostication in dogs with mast cell neoplasms and should thereby support management of these patients in daily practice and the conduct of clinical trials. |
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Copyright © 2021 Willmann, Yuzbasiyan-Gurkan, Marconato, Dacasto, Hadzijusufovic, Hermine, Sadovnik, Gamperl, Schneeweiss-Gleixner, Gleixner, Böhm, Peter, Eisenwort, Moriggl, Li, Jawhar, Sotlar, Jensen-Jarolim, Sexl, Horny, Galli, Arock, Vail, Kiupel and Valent. |
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KEYWORDS: KIT mutations, canine mast cell neoplasm, classification, grading, staging, targeted therapy, treatment algorithms |
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Publikations ID: 34957277 Quelle: öffnen |
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