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| Vaccines. 2021 Aug 15. pii: vaccines9080908. doi: 10.3390/vaccines9080908 |
| Tick-Borne Encephalitis Specific Lymphocyte Response after Allogeneic Hematopoietic Stem Cell Transplantation Predicts Humoral Immunity after Vaccination. |
| Harrison N1, Grabmeier-Pfistershammer K2, Graf A3, Trapin D4, Tauber P5, Aberle JH6, Stiasny K7, Schmidt R8, Greinix H9, Rabitsch W10, Ramharter M11, Burgmann H12, Pickl WF13, Bahrs C14 |
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Abstract The aim of this prospective study was to assess lymphocyte proliferative and cytokine response prior to and following tick-borne encephalitis (TBE) immunization among patients after allogeneic hematopoietic stem cell transplantation (HSCT). Seventeen adult patients 11-13 months after HSCT and eight unvaccinated healthy adults received up to three TBE vaccinations. Following in vitro stimulation with TBE-antigen, lymphocyte proliferation and cytokine secretion (IL-2, IL-10, IL-13, TNF-alpha, IFN-gamma, GM-CSF) were analyzed by thymidine incorporation assay and the Luminex system. Ten patients (59%) showed significant baseline TBE-specific lymphocyte proliferation (stimulation index (SI) > 3) prior to vaccination, but none of the unvaccinated controls ( = 0.002). All patients with a TBE-specific antibody response after two vaccinations (at least 2-fold increase of neutralization test titers) exhibited a strong TBE-specific lymphocyte proliferative response at baseline (SI > 10). Patients with sibling donors had a significantly stronger baseline TBE-specific lymphocyte proliferative and IL-13 cytokine response than patients with unrelated donors ( < 0.05). In conclusion, a relevant proportion of patients showed TBE-specific lymphocyte proliferative and cytokine responses prior to vaccination after HSCT, which predicted the humoral response to the vaccine. Patients with vaccinated sibling donors were more likely to elicit a cellular immune response than patients with unrelated donors of unknown vaccination status. |
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KEYWORDS: allogeneic stem cell transplant, cytokine response, humoral responders, interleukin 13, lymphocyte proliferation, sibling donors, tick-borne encephalitis vaccination |
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Publikations ID: 34452033 Quelle: öffnen |
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