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| Seminars in radiation oncology. pii: S1053-4296(20)30041-2. doi: 10.1016/j.semradonc.2020.05.008 |
| Evidence-Based Dose Planning Aims and Dose Prescription in Image-Guided Brachytherapy Combined With Radiochemotherapy in Locally Advanced Cervical Cancer. |
| Tanderup K1, Nesvacil N2, Kirchheiner K3, Serban M4, Spampinato S5, Jensen NBK6, Schmid M7, Smet S8, Westerveld H9, Ecker S10, Mahantshetty U11, Swamidas J12, Chopra S13, Nout R14, Tan LT15, Fokdal L16, Sturdza A17, Jürgenliemk-Schulz I18, de Leeuw A19, Lindegaard JC20, Kirisits C21, Pötter R22 |
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Abstract The last 2 decades have witnessed the development and broad adoption of image-guided adaptive brachytherapy (IGABT) combined with radiochemotherapy in patients with locally advanced cervical cancer. A variety of brachytherapy techniques and dose/fractionation schedules have been applied, and until recently, there was no strong evidence available for preferring one approach to another. However, large volumes of data have now provided high level clinical evidence for dose-effect relations for both disease and morbidity endpoints. It is therefore now possible to apply evidence based dose planning aims and dose prescription protocols in IGABT for locally advanced cervical cancer. This review gives an overview of targets/organs-at-risk and disease/morbidity endpoints which are relevant in the context of treatment planning and dose prescription in IGABT. The dosimetric and clinical evidence is summarized to support the implementation of dose prescription protocols which include hard and soft constraints for targets and organs at risk. |
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Copyright © 2020 Elsevier Inc. All rights reserved. |
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Publikations ID: 32828387 Quelle: öffnen |
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