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| NPJ vaccines. 2020 Jul 24. doi: 10.1038/s41541-020-00215-1. pii: 215. pmc: PMC7381595 |
| Humoral immune response to tick-borne encephalitis vaccination in allogeneic blood and marrow graft recipients. |
| Harrison N1, Grabmeier-Pfistershammer K2, Graf A3, Schwarzinger I4, Aberle JH5, Stiasny K6, Greinix H7, Rabitsch W8, Kalhs P9, Ramharter M10, Burgmann H11, Forstner C12 |
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Abstract The aim of this prospective study was to characterize the humoral immune response to TBE vaccination after hematopoietic stem cell transplantation (HSCT). Nineteen adult patients 11-13 months after HSCT and 15 age-matched immunocompetent adults received up to three TBE vaccinations. Antibodies against TBE virus were measured by neutralization test (NT). As primary endpoint, the antibody response (NT titer of ≥10 and at least a twofold increase from baseline 4 weeks after second vaccination) was compared between patients and controls using Fisher exact test. Prior vaccination, 15 (79%) HSCT patients still had detectable neutralizing antibodies. At primary endpoint, the antibody response was significantly lower in patients than in controls (35% versus 93%; < 0.001). The CD4+ cell count was a predictor for an antibody response in patients ( = 0.019). Interestingly, the majority of HSCT patients still had detectable antibodies prior vaccination. Following vaccination, antibody response in HSCT patients was associated with the CD4+ cell count. |
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© The Author(s) 2020. |
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KEYWORDS: Haematological cancer, Inactivated vaccines, Viral infection |
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Publikations ID: 32728481 Quelle: öffnen |
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