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| Clinical and translational allergy. 2020 Jul 17. doi: 10.1186/s13601-020-00335-w. pii: 335. pmc: PMC7366896 |
| AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer-a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI). |
| Ferastraoaru D1, Bax HJ2, Bergmann C3, Capron M4, Castells M5, Dombrowicz D6, Fiebiger E7, Gould HJ8, Hartmann K9, Jappe U10, Jordakieva G11, Josephs DH12, Levi-Schaffer F13, Mahler V14, Poli A15, Rosenstreich D16, Roth-Walter F17, Shamji M18, Steveling-Klein EH19, Turner MC20, Untersmayr E21, Karagiannis SN22, Jensen-Jarolim E23 |
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Abstract Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted. |
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© The Author(s) 2020. |
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KEYWORDS: Allergy diagnosis, Atopy, Cancer, IgE, Malignancy |
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Publikations ID: 32695309 Quelle: öffnen |
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