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| Acta biomaterialia. 2020 Apr 23. pii: S1742-7061(20)30188-4. doi: 10.1016/j.actbio.2020.03.047 |
| Bimodality Probes of Gd Enhanced T1-Weighted Magnetic Resonance/Optical Imaging. |
| Yang CT1, Hattiholi A2, Selvan ST3, Yan SX4, Fang WW5, Chandrasekharan P6, Koteswaraiah P7, Herold CJ8, Gulyás B9, Aw SE10, He T11, Ng DCE12, Padmanabhan P13 |
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Abstract Gd-based contrast agents have been extensively used for signal enhancement of T-weighted magnetic resonance imaging (MRI) due to the large magnetic moment and long electron spin relaxation time of the paramagnetic Gd ion. The key requisites for the development of Gd-based contrast agents are their relaxivities and stabilities which can be achieved by chemical modifications. These modifications include coordinating Gd with a chelator such as diethylenetriamine pentaacetic acid (DTPA) or 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), encapsulating Gd in nanoparticles, conjugation to biomacromolecules such as polymer micelles and liposomes, or non-covalent binding to plasma proteins. In order to have a coherent diagnostic and therapeutic approach and to understand diseases better, the combination of MRI and optical imaging (OI) techniques into one technique entity has been developed to overcome the conventional boundaries of either imaging modality used alone through bringing the excellent spatial resolution of MRI and high sensitivity of OI into full play. Novel MRI and OI bimodal probes have been extensively studied in this regard. This review is an attempt to shed some light on the bimodal imaging probes by summarizing all recent noteworthy publications involving Gd containing MR-optical imaging probes. The several key elements such as novel synthetic strategy, high sensitivity, biocompatibility, and targeting of the probes are highlighted in the review. |
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Copyright © 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. |
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KEYWORDS: Bimodality imaging probe, MRI, contrast agent, nanomaterials, optical imaging |
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Publikations ID: 32335310 Quelle: öffnen |
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