Abk�rzung zur Hauptnavigation Abk�rzung zu den Newsmeldungen Abk�rzung zu den Topstories  
  Barrierefreiheit    Kontakt MedUni Wien    Intranet    MedUni Wien - Shop    Universitätsbibliothek    Universitätsklinikum AKH Wien  
 
ccc_logo_en.gif
 
AKH Wien
 
 
Hauptnavigation
  • Home
  • Über das CCC
    • Allgemeines
    • Leitung der Organisationseinheit
    • CCC-Office Team
    • Kliniken und Partner
    • Qualitätsmanagement
    • Kontakt
  • PatientInnen
    • Covid-19
    • Allgemeines
    • Cancer School
    • Terminvereinbarung
    • Pflegeambulanz
    • PatientInnenvertretung
    • Links
  • Klinischer Bereich
    • Allgemeines
    • CCC Tumorboards
  • Wissenschaft & Forschung
    • Young CCC
    • CCC-ExpertInnenvideos
    • CCC Forschungscluster
    • CCC Units
    • CCC Platforms
    • Translationale Forschung
    • CCC Best Paper Award
    • CCC-TRIO Symposium
    • Kontakt/Links
  • Lehre
    • CCC Cancer School
    • CCC Cancer Update
    • Vienna International Summer School on Clinical and Experimental Oncology - VSSO
    • Interdisziplinäre onkologische Ausbildung
    • Klinisch-Praktisches Jahr (KPJ)
    • PhD Programme
    • Postgraduelle Fort- und Weiterbildung
    • Information/Contact
 
 
Subnavigation
    Inhaltsbereich


    Zurück zur Übersicht
    Cancer discovery. 2020 Apr 1. pii: 2159-8290.CD-19-1030. doi: 10.1158/2159-8290.CD-19-1030
    Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes.
    Clarke M1,  Mackay A2,  Ismer B3,  Pickles JC4,  Tatevossian RG5,  Newman S6,  Bale TA7,  Stoler I8,  Izquierdo E9,  Temelso S10,  Carvalho DM11,  Molinari V12,  Burford A13,  Howell L14,  Virasami A15,  Fairchild AR16,  Avery A17,  Chalker J18,  Kristiansen M19,  Haupfear K20,  Dalton JD21,  Orisme W22,  Wen J23,  Hubank M24,  Kurian KM25,  Rowe C26,  Maybury M27,  Crosier S28,  Knipstein J29,  Schuller U30,  Kordes U31,  Kram DE32,  Snuderl M33,  Bridges L34,  Martin AJ35,  Doey LJ36,  Al-Sarraj S37,  Chandler C38,  Zebian B39,  Cairns C40,  Natrajan R41,  Boult JK42,  Robinson SP43,  Sill M44,  Dunkel IJ45,  Gilheeney SW46,  Rosenblum MK47,  Hughes D48,  Proszek PZ49,  MacDonald TJ50,  Preusser M51,  Haberler C52,  Slavc I53,  Packer R54,  Ng HK55,  Caspi S56,  Popovic M57,  Faganel Kotnik B58,  Wood MD59,  Baird L60,  Davare MA61,  Solomon DA62,  Olsen TK63,  Brandal P64,  Farrell M65,  Cryan JB66,  Capra M67,  Karremann M68,  Schittenhelm J69,  Schuhmann MU70,  Ebinger M71,  Dinjens WNM72,  Kerl K73,  Hettmer S74,  Pietsch T75,  Andreiuolo F76,  Driever PH77,  Korshunov A78,  Hiddingh L79,  Worst BC80,  Sturm D81,  Zuckermann M82,  Witt O83,  Bloom T84,  Mitchell C85,  Miele E86,  Colafati GS87,  Diomedi-Camassei F88,  Bailey S89,  Moore AS90,  Hassall TE91,  Lowis SP92,  Tsoli M93,  Cowley MJ94,  Ziegler DS95,  Karajannis MA96,  Aquilina K97,  Hargrave DR98,  Carceller F99,  Marshall LV100,  von Deimling A101,  Kramm CM102,  Pfister SM103,  Sahm F104,  Baker SJ105,  Mastronuzzi A106,  Carai A107,  Vinci M108,  Capper D109,  Popov S110,  Ellison DW111,  Jacques TS112,  Jones DTW113,  Jones C114
    Author information
    1Section of Medicine, Institute of Cancer Research.
    2The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research.
    3Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    4Developmental Biology and Cancer Research & Teaching Department, UCL GOS Institute of Child Health.
    5Neuropathology and Solid Tumor Pathology Department of Patholog, St. Jude Children's Research Hospital.
    6Department of Computational Biology, St. Jude Children's Research Hospital.
    7Pathology, Memorial Sloan Kettering Cancer Center.
    8Department of Pediatric Oncology and Hematology, Charite Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health.
    9Molecular Pathology, Institute of Cancer Research.
    10Division of Cancer Therapeutics and Department of Molecular Pathology, Institute of Cancer Research.
    11Institute of Cancer Research.
    12Molecular Pathology, Institute of Cancer Research.
    13Paediatric Oncology, Institute of Cancer Research.
    14Haemato-Oncology Research Unit, Division of Molecular Pathology, Institute of Cancer Research.
    15Institute of Child Health, UCL.
    16Neural Development Unit, UCL Institute of Child Health.
    17Neural Development Unit, UCL Institute of Child Health.
    18Neural Development Unit, UCL Institute of Child Health.
    19Genetics and Genomic Medicine, UCL Institute of Child Health.
    20Pathology, St. Jude Children's Research Hospital.
    21Pathology, St. Jude Children's Research Hospital.
    22Neuropathology and Solid Tumor Pathology Department of Patholog, St. Jude Children's Research Hospital.
    23Pathology, St. Jude Children's Research Hospital.
    24Clinical Genomics, Royal Marsden Hospital.
    25Department of Neuropathology, Brain Tumour Research Group, Frenchay Hospital, University of Bristol.
    26U Bristol.
    27U Queensland.
    28Wolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer.
    29Department of Pediatrics, Division of Hematology/Oncology/BMT, Medical College of Wisconsin.
    30Institute of Neuropathology, University Medical Center Hamburg-Eppendorf.
    31University Medical Center Eppendorf.
    32Pediatrics, Wake Forest School of Medicine.
    33Pathology, NYU Langone Medical Center.
    34Department of Cellular Pathology, St Georges Hospital.
    35Neurosurgery, St George's Healthcare NHS Trust.
    36Neuropathology, King's College Hospital.
    37Neuropathology, King's College Hospital.
    38Pathology, King's College Hospital.
    39Neurosurgery, St George's Healthcare NHS Trust.
    40Neuropathology, King's College Hospital.
    41The Breast Cancer Now Toby Robins Breast Cancer Research Centre, Institute of Cancer Research.
    42Radiotherapy and Imaging, Institute of Cancer Research.
    43Division of Radiotherapy and Imaging, The Institute of Cancer Research, London.
    44Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    45Pediatrics, Memorial Sloan Kettering Cancer Center.
    46Pediatrics, Memorial Sloan Kettering Cancer Center.
    47Pathology, Memorial Sloan Kettering Cancer Center.
    48Centre for Molecular Pathology, The Royal Marsden.
    49Centre for Molecular Pathology, The Royal Marsden.
    50Pediatric Hematology/Oncology, Emory University School of Medicine.
    51Department of Internal Medicine 1, Medical University of Vienna.
    52Institute of Neurology, Medical University of Vienna.
    53Pediatrics and Adolescent Medicine, Medical University of Vienna.
    54Dept of Neurology, Children's National Health System.
    55Anatomical and Cellular Pathology, The Chinese Univesity of Hong Kong.
    56Pediatric oncology, Sheba Medical Center.
    57Institute of Pathology, University of Ljubljana, Faculty of Medicine.
    58Dept. of pediatric hematology and oncology, Ljubljana University Medical Centre.
    59Pathology, Oregon Health & Science University.
    60Pediatrics, OHSU.
    61Pediatrics, OHSU.
    62Pathology, University of California, San Francisco.
    63Karolinska Institute.
    64Institute for Medical Informatics, The Norwegian Radium Hospital,Oslo University Hospital, Oslo, Norway, Section for Cancer Cytogenetics.
    65Pathology, Brigham and Women's Hospital.
    66Pathology, Brigham and Women's Hospital.
    67Pathology, Brigham and Women's Hospital.
    68Pediatric Oncology, University Medical Centre Mannheim.
    69Neuropathology, University of Tuebingen.
    70Pediatric Neurosurgery, University Hospital Tubingen.
    71Hematology and Oncology, University Children's Hospital.
    72Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam.
    73Medical Faculty of WWU Muenster, Institute of Molecular Tumor Biology (IMTB).
    74Pediatric Hematology and Oncology, University Medical Center.
    75University Hospital Bonn.
    76University Hospital Bonn.
    77Department of Neuropathology, Charite Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health.
    78Neuropathology, Heidelberg University, German Cancer Research Center (DKFZ).
    79Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    80Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    81Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    82Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    83Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    84Southampton Children's Hospital.
    85University of Southampton.
    86Hematology/Oncology, IRCCS Ospedale Bambino Gesu.
    87Imaging Department, Bambino Gesu Children's Hospital.
    88Laboratories-Pathology Unit, Bambino Gesu Children's Hospital.
    89Department of Paediatric and Adolescent Haematology and Oncology, Great North Children's Hospital NHS Trust.
    90Oncology, Queensland Children's Hospital.
    91Lady Cilento Children's Hospital.
    92Paediatric Oncology, Bristol Royal Hospital for Children.
    93Brain Tumour Group, Children's Cancer Institute.
    94Precision Medicine, Children's Cancer Institute Australia.
    95Kids Cancer Centre, Sydney Children's Hospital.
    96Pediatrics, Memorial Sloan Kettering Cancer Center.
    97Neural Development Unit, UCL Institute of Child Health.
    98Paediatric Oncology, Great Ormond Street Hospital.
    99Pediatric Oncology, Royal Marsden NHS Foundation Trust.
    100Pediatrics, Royal Marsden Hospital.
    101Neuropathology and Clinical Cooperation Unit Neuropathology, University Heidelberg and German Cancer Center (DKFZ).
    102Division of Pediatric Hematology and Oncology, Goettingen.
    103Pediatric Neurooncology, Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    104Dept of Neuropathology, University Hospital Heidelberg and CCU Neuropatrhology, German Consotrium for Translational Cancer Research (DKTK), and Hopp Childrens' Tumor Center, University Hospital Heidelberg and German Cancer Research Center (DKFZ).
    105Developmental Neurobiology, St. Jude Children's Research Hospital.
    106Department of Hematology/Oncology and Stem Cell Transplantation, Bambino Gesu Children's Hospital, IRCCS.
    107Department of Neuroscience and Neurorehabilitation, Neurosurgery Unit, Bambino Gesu Children's Hospital, IRCCS.
    108Bambino Gesu Children's Hospital.
    109Department of Neuropathology, Charite Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, and Berlin Institute of Health.
    110Division of Cancer Therapeutics and Department of Molecular Pathology, Institute of Cancer Research.
    111Pathology, St. Jude Children's Research Hospital.
    112Neural Development Unit, UCL Institute of Child Health.
    113Hopp Children's Cancer Center at the NCT Heidelberg (KiTZ).
    114Division of Cancer Therapeutics and Department of Molecular Pathology, Institute of Cancer Research chris.jones@icr.ac.uk.
    Abstract

    Infant high grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histological review, methylation profiling, custom panel and genome/exome sequencing. After excluding tumors representing other established entities or subgroups, we identified 130 cases to be part of an 'intrinsic' spectrum of disease specific to the infant population. These included those with targetable MAP-kinase alterations, and a large proportion of remaining cases harboring gene fusions targeting ALK (n=31), NTRK1/2/3 (n=21), ROS1 (n=9) and MET (n=4) as their driving alterations, with evidence of efficacy of targeted agents in the clinic. These data strongly supports the concept that infant gliomas require a change in diagnostic practice and management.


    Copyright ©2020, American Association for Cancer Research.

    Publikations ID: 32238360
    Quelle: öffnen
     
    Drucken
     
    ccc_logo_en.gif
    ccc_logo_en.gif
    ccc_logo_en.gif

    Schnellinfo

     
    -- Initiative Krebsforschung / Krebsforschungslauf

    -- Cancer Care
    -- Kliniken und Partner
    -- CCC Cancer School
    -- Young CCC
    -- CCC Tumorboards
    -- CCC Forschungscluster
    -- CCC Units
    -- CCC Platforms
    -- SOPs / Leitlinien
    -- Kontakt
    Zuklappen
     
    Ausklappen
     
     

    Featured

     
     
     
     
     
     
     
     
     
     
     
     
     
    © MedUni Wien |
     Impressum | Nutzungsbedingungen | Kontakt