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| International journal of molecular sciences. 2020 Mar 16. pii: ijms21062027. doi: 10.3390/ijms21062027 |
| Recent Advances in Practical Methods for Liver Cell Biology: A Short Overview. |
| Torres S1, Abdullah Z2, Brol MJ3, Hellerbrand C4, Fernandez M5, Fiorotto R6, Klein S7, Königshofer P8, Liedtke C9, Lotersztajn S10, Nevzorova YA11, Schierwagen R12, Reiberger T13, Uschner FE14, Tacke F15, Weiskirchen R16, Trebicka J17 |
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Abstract Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, paving the path for 2D and 3D microscopy and high-throughput assays (e.g., bulk or single-cell RNA sequencing). The use of stem cell and organoid research will help to decipher the pathophysiology of liver diseases and the interaction between various parenchymal and non-parenchymal liver cells. Furthermore, sophisticated animal models of liver disease allow for the in vivo assessment of fibrogenesis, portal hypertension and hepatocellular carcinoma (HCC) and for the preclinical testing of therapeutic strategies. The purpose of this review is to portray in detail novel in vitro and in vivo methods for the study of liver cell biology that had been presented at the workshop of the 8th meeting of the European Club for Liver Cell Biology (ECLCB-8) in October of 2018 in Bonn, Germany. |
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KEYWORDS: fibrogenesis, hepatic stellate cells, hepatocellular cancer, in vitro models, steatosis |
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Publikations ID: 32188134 Quelle: öffnen |
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