Journal of ophthalmology. 2020 Feb 17. doi: 10.1155/2020/8491712. pmc: PMC7049425 |
Long-Term Effect of Half-Fluence Photodynamic Therapy on Fundus Autofluorescence in Acute Central Serous Chorioretinopathy. |
Stattin M1, Hagen S2, Ahmed D3, Smretschnig E4, Frommlet F5, Krepler K6, Ansari-Shahrezaei S7 |
Abstract PURPOSE: To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm). METHODS: Quantitative data of SW-FAF grey values (SW-FAF GV) from a 350 m (SW-350) and 1200 m (SW-350) and 1200 -test was calculated to explore the differences of SW-350 and SW-1200 between one month and the long-term follow-up. RESULTS: Mean differences (95% CI) in SW-FAF GV between 1 month and 7 years after half-fluence PDT were 0.07 ± 0.11 for SW-350 ([95% CI: -0.002; 0.14], =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21], =0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI: 0.01; 0.21]. CONCLUSION: After 7 years, normalized SW-FAF GV were significantly lower in eyes with resolved acute CSCR treated with reduced-fluence PDT compared to the follow-up after 1 month without correlation to explicit pattern changes or structural damages. Half-fluence PDT remains a safe and considerable treatment option in acute CSCR. |
Copyright © 2020 Martin Stattin et al. |
Publikations ID: 32148947 Quelle: öffnen |