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Chemistry (Weinheim an der Bergstrasse, Germany). 2019 Sep 27. doi: 10.1002/chem.201903605

The first anticancer tris(pyrazolyl)borate molybdenum(IV) complexes: tested in vitro and in vivo - a comparison of O,O-, S,O-, and N,N-chelate effects.

Berasaluce I¹, Cseh K², Roller A³, Hejl M⁴, Heffeter P⁵, Berger W⁶, Jakupec MA⁷, Kandioller W⁸, Malarek MS⁹, Keppler BK¹⁰

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¹Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria, AUSTRIA.
²Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria, AUSTRIA.
³Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria, AUSTRIA.
⁴Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria, AUSTRIA.
⁵Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria. Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Aust, AUSTRIA.
⁶Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria. Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, Borschkegasse 8a, A-1090, Vienna, Aust, AUSTRIA.
⁷Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria. Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria, AUSTRIA.
⁸Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria. Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria, AUSTRIA.
⁹Universitat Wien, Institute of Inorganic Chemistry, Währinger Straße 42, 1090, Vienna, AUSTRIA.
¹⁰Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria. Research Cluster 'Translational Cancer Therapy Research', University of Vienna, Waehringer Straße 42, A-1090 Vienna, Austria, AUSTRIA.

Abstract

The synthesis, characterization and biological activity of molybdenum(IV) complexes containing Trofimenko's scorpionato ligand, hydrotris(3-isopropylpyrazolyl)borate (TpiPr), in addition to varying biologically active as well as other conventional ligands is described. Ligands employed include (O,O-) (S,O-) (N,N-) donors which have been successfully coordinated to the molybdenum center by means of oxygen-atom transfer (OAT) reactions from the known MoVI starting material, TpiPrMoO2Cl. The synthesized complexes were characterized by standard analytical methods, and where possible by X-ray diffraction analysis. The aqueous stability of the compounds was studied by means of UV/Vis spectroscopy and the impact of the attached ligand scaffolds on the oxidation potentials (MoIV to MoV) was studied by cyclic voltammetry. Utilizing polyvinylpyrrolidone (PVP) as a solubilizing agent, adequate aqueous solubility for biological tests was obtained. The anticancer activity and preliminary mode of action studies have been performed in vitro and in vivo.

KEYWORDS: anticancer, biological tests, in vivo experiments, molybdenum, tris(pyrazolyl)borate

Publikations ID: 31560142
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