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    Science (New York, N.Y.). pii: 365/6457/eaat7487. doi: 10.1126/science.aat7487
    The formation of human populations in South and Central Asia.
    Narasimhan VM1,  Patterson N2,  Moorjani P3,  Rohland N4,  Bernardos R5,  Mallick S6,  Lazaridis I7,  Nakatsuka N8,  Olalde I9,  Lipson M10,  Kim AM11,  Olivieri LM12,  Coppa A13,  Vidale M14,  Mallory J15,  Moiseyev V16,  Kitov E17,  Monge J18,  Adamski N19,  Alex N20,  Broomandkhoshbacht N21,  Candilio F22,  Callan K23,  Cheronet O24,  Culleton BJ25,  Ferry M26,  Fernandes D27,  Freilich S28,  Gamarra B29,  Gaudio D30,  Hajdinjak M31,  Harney É32,  Harper TK33,  Keating D34,  Lawson AM35,  Mah M36,  Mandl K37,  Michel M38,  Novak M39,  Oppenheimer J40,  Rai N41,  Sirak K42,  Slon V43,  Stewardson K44,  Zalzala F45,  Zhang Z46,  Akhatov G47,  Bagashev AN48,  Bagnera A49,  Baitanayev B50,  Bendezu-Sarmiento J51,  Bissembaev AA52,  Bonora GL53,  Chargynov TT54,  Chikisheva T55,  Dashkovskiy PK56,  Derevianko A57,  Dobeš M58,  Douka K59,  Dubova N60,  Duisengali MN61,  Enshin D62,  Epimakhov A63,  Fribus AV64,  Fuller D65,  Goryachev A66,  Gromov A67,  Grushin SP68,  Hanks B69,  Judd M70,  Kazizov E71,  Khokhlov A72,  Krygin AP73,  Kupriyanova E74,  Kuznetsov P75,  Luiselli D76,  Maksudov F77,  Mamedov AM78,  Mamirov TB79,  Meiklejohn C80,  Merrett DC81,  Micheli R82,  Mochalov O83,  Mustafokulov S84,  Nayak A85,  Pettener D86,  Potts R87,  Razhev D88,  Rykun M89,  Sarno S90,  Savenkova TM91,  Sikhymbaeva K92,  Slepchenko SM93,  Soltobaev OA94,  Stepanova N95,  Svyatko S96,  Tabaldiev K97,  Teschler-Nicola M98,  Tishkin AA99,  Tkachev VV100,  Vasilyev S101,  Velemínský P102,  Voyakin D103,  Yermolayeva A104,  Zahir M105,  Zubkov VS106,  Zubova A107,  Shinde VS108,  Lalueza-Fox C109,  Meyer M110,  Anthony D111,  Boivin N112,  Thangaraj K113,  Kennett DJ114,  Frachetti M115,  Pinhasi R116,  Reich D117
    Author information
    1Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. vagheesh@mail.harvard.edu nickp@broadinstitute.org frachetti@wustl.edu ron.pinhasi@univie.ac.at reich@genetics.med.harvard.edu.
    2Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. vagheesh@mail.harvard.edu nickp@broadinstitute.org frachetti@wustl.edu ron.pinhasi@univie.ac.at reich@genetics.med.harvard.edu.
    3Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
    4Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    5Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    6Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    7Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    8Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    9Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    10Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    11Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    12ISMEO - International Association of Mediterranean and Oriental Studies, Italian Archaeological Mission in Pakistan, 19200 Saidu Sharif (Swat), Pakistan.
    13Department of Environmental Biology, Sapienza University, Rome 00185, Italy.
    14ISMEO - International Association of Mediterranean and Oriental Studies, Italian Archaeological Mission in Pakistan, 19200 Saidu Sharif (Swat), Pakistan.
    15School of Natural and Built Environment, Queen's University Belfast, Belfast BT7 1NN, Northern Ireland, UK.
    16Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Science, St. Petersburg 199034, Russia.
    17Center of Physical Anthropology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow 119991, Russia.
    18University of Pennsylvania Museum of Archaeology and Anthropology, Philadelphia, PA 19104, USA.
    19Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    20Department of Electrical Engineering and Computer Science, University of California, Berkeley, CA 94720, USA.
    21Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    22Earth Institute, University College Dublin, Dublin 4, Ireland.
    23Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    24Earth Institute, University College Dublin, Dublin 4, Ireland.
    25Institutes of Energy and the Environment, Pennsylvania State University, University Park, PA 16802, USA.
    26Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    27Earth Institute, University College Dublin, Dublin 4, Ireland.
    28Department of Evolutionary Anthropology, University of Vienna, 1090 Vienna, Austria.
    29Earth Institute, University College Dublin, Dublin 4, Ireland.
    30Earth Institute, University College Dublin, Dublin 4, Ireland.
    31Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
    32Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    33Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA.
    34Earth Institute, University College Dublin, Dublin 4, Ireland.
    35Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    36Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    37Department of Evolutionary Anthropology, University of Vienna, 1090 Vienna, Austria.
    38Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    39Earth Institute, University College Dublin, Dublin 4, Ireland.
    40Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    41CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
    42Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    43Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
    44Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    45Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    46Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
    47A.Kh. Margulan Institute of Archaeology, Almaty 050010, Kazakhstan.
    48Tyumen Scientific Centre SB RAS, Institute of the Problems of Northern Development, Tyumen 625003, Russia.
    49ISMEO - International Association of Mediterranean and Oriental Studies, Italian Archaeological Mission in Pakistan, 19200 Saidu Sharif (Swat), Pakistan.
    50A.Kh. Margulan Institute of Archaeology, Almaty 050010, Kazakhstan.
    51CNRS-EXT500, Directeur de la Delegation Archaologique Francaise en Afghanistan (DAFA), Embassy of France in Kabul, Afghanistan.
    52A.Kh. Margulan Institute of Archaeology, Almaty 050010, Kazakhstan.
    53Archaeology of Asia Department, ISMEO - International Association of Mediterranean and Oriental Studies, Rome RM00186, Italy.
    54Kyrgyz National University, 720033 Bishkek, Kyrgyzstan.
    55Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia.
    56Department of Political History, National and State-Confessional Relations, Altai State University, Barnaul 656049, Russia.
    57Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia.
    58Institute of Archaeology, Czech Academy of Sciences, Prague 118 01, Czech Republic.
    59Department of Archaeology, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
    60Center of Physical Anthropology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow 119991, Russia.
    61Aktobe Regional Historical Museum, Aktobe 030006, Kazakhstan.
    62Tyumen Scientific Centre SB RAS, Institute of the Problems of Northern Development, Tyumen 625003, Russia.
    63Institute of History and Archaeology, Ural Branch RAS, Yekaterinburg 620990, Russia.
    64Department of Archaeology, Kemerovo State University, Kemerovo 650043, Russia.
    65Institute of Archaeology, University College London, London WC1H 0PY, UK.
    66Tyumen Scientific Centre SB RAS, Institute of the Problems of Northern Development, Tyumen 625003, Russia.
    67Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Science, St. Petersburg 199034, Russia.
    68Department of Archaeology, Ethnography and Museology, Altai State University, Barnaul 656049, Russia.
    69Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
    70Department of Anthropology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
    71A.Kh. Margulan Institute of Archaeology, Almaty 050010, Kazakhstan.
    72Samara State University of Social Sciences and Education, Samara 443099, Russia.
    73West Kazakhstan Regional Center for History and Archaeology, Uralsk 090000, Kazakhstan.
    74Scientific and Educational Center of Study on the Problem of Nature and Man, Chelyabinsk State University, Chelyabinsk 454021, Russia.
    75Samara State University of Social Sciences and Education, Samara 443099, Russia.
    76Department of Cultural Heritage, University of Bologna, 48121 Ravenna, Italy.
    77Institute for Archaeological Research, Uzbekistan Academy of Sciences, Samarkand 140151, Uzbekistan.
    78Center for Research, Restoration and Protection of Historical and Cultural Heritage of Aktobe Region, Aktobe 030007, Kazakhstan.
    79A.Kh. Margulan Institute of Archaeology, Almaty 050010, Kazakhstan.
    80Department of Anthropology, University of Winnipeg, Winnipeg, MB R3B 2E9, Canada.
    81Department of Archaeology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada.
    82ISMEO - International Association of Mediterranean and Oriental Studies, Italian Archaeological Mission in Pakistan, 19200 Saidu Sharif (Swat), Pakistan.
    83Samara State University of Social Sciences and Education, Samara 443099, Russia.
    84Institute for Archaeological Research, Uzbekistan Academy of Sciences, Samarkand 140151, Uzbekistan.
    85Department of Archaeology, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
    86Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum - University of Bologna, Bologna 40126, Italy.
    87Human Origins Program, National Museum of Natural History, Smithsonian Institution, Washington, DC 20013, USA.
    88Tyumen Scientific Centre SB RAS, Institute of the Problems of Northern Development, Tyumen 625003, Russia.
    89National Research Tomsk State University, Tomsk 634050, Russia.
    90Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum - University of Bologna, Bologna 40126, Italy.
    91F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk 660022, Russia.
    92Central State Museum Republic of Kazakhstan, Samal-1 Microdistrict, Almaty 050010, Kazakhstan.
    93Tyumen Scientific Centre SB RAS, Institute of the Problems of Northern Development, Tyumen 625003, Russia.
    94Kyrgyz National University, 720033 Bishkek, Kyrgyzstan.
    95Institute of Archaeology and Ethnography, Siberian Branch, Russian Academy of Sciences, Novosibirsk 630090, Russia.
    96Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Science, St. Petersburg 199034, Russia.
    97Kyrgyz-Turkish Manas University, Bishkek, Kyrgyzstan.
    98Department of Evolutionary Anthropology, University of Vienna, 1090 Vienna, Austria.
    99Department of Archaeology, Ethnography and Museology, The Laboratory of Interdisciplinary Studies in Archaeology of Western Siberia and Altai, Altai State University, Barnaul 656049, Russia.
    100Institute of Steppe, Ural Branch RAS, Orenburg 460000, Russia.
    101Center of Physical Anthropology, Institute of Ethnology and Anthropology, Russian Academy of Sciences, Moscow 119991, Russia.
    102Department of Anthropology, National Museum, Prague 115 79, Czech Republic.
    103A.Kh. Margulan Institute of Archaeology, Almaty 050010, Kazakhstan.
    104A.Kh. Margulan Institute of Archaeology, Almaty 050010, Kazakhstan.
    105Department of Archaeology, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
    106N.F. Katanov Khakassia State University, Abakan 655017, Russia.
    107Peter the Great Museum of Anthropology and Ethnography (Kunstkamera), Russian Academy of Science, St. Petersburg 199034, Russia.
    108Department of Archaeology, Deccan College Post-Graduate and Research Institute, Pune 411006, India.
    109Institute of Evolutionary Biology, CSIC-Universitat Pompeu Fabra, Barcelona 08003, Spain.
    110Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany.
    111Anthropology Department, Hartwick College, Oneonta, NY 13820, USA.
    112Department of Archaeology, Max Planck Institute for the Science of Human History, Jena 07745, Germany.
    113CSIR-Centre for Cellular and Molecular Biology, Hyderabad 500 007, India.
    114Institutes of Energy and the Environment, Pennsylvania State University, University Park, PA 16802, USA.
    115Department of Anthropology, Washington University in St. Louis, St. Louis, MO 63112, USA. vagheesh@mail.harvard.edu nickp@broadinstitute.org frachetti@wustl.edu ron.pinhasi@univie.ac.at reich@genetics.med.harvard.edu.
    116Earth Institute, University College Dublin, Dublin 4, Ireland. vagheesh@mail.harvard.edu nickp@broadinstitute.org frachetti@wustl.edu ron.pinhasi@univie.ac.at reich@genetics.med.harvard.edu.
    117Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. vagheesh@mail.harvard.edu nickp@broadinstitute.org frachetti@wustl.edu ron.pinhasi@univie.ac.at reich@genetics.med.harvard.edu.
    Abstract

    By sequencing 523 ancient humans, we show that the primary source of ancestry in modern South Asians is a prehistoric genetic gradient between people related to early hunter-gatherers of Iran and Southeast Asia. After the Indus Valley Civilization's decline, its people mixed with individuals in the southeast to form one of the two main ancestral populations of South Asia, whose direct descendants live in southern India. Simultaneously, they mixed with descendants of Steppe pastoralists who, starting around 4000 years ago, spread via Central Asia to form the other main ancestral population. The Steppe ancestry in South Asia has the same profile as that in Bronze Age Eastern Europe, tracking a movement of people that affected both regions and that likely spread the distinctive features shared between Indo-Iranian and Balto-Slavic languages.


    Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

    Publikations ID: 31488661
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