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    International journal of cancer. 2019 Aug 29. doi: 10.1002/ijc.32651
    EORTC SPECTA-AYA: A unique molecular profiling platform for adolescents and young adults with cancer in Europe.
    de Rojas T1,  Kasper B2,  Van der Graaf W3,  Pfister SM4,  Bielle F5,  Ribalta T6,  Shenjere P7,  Preusser M8,  Fröhling S9,  Golfinopoulos V10,  Morfouace M11,  McCabe MG12
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    Abstract

    For most adolescent and young adult (AYA) cancers, age-specific molecular features are poorly understood. SPECTA, an academic translational research infrastructure for biomaterial collection, will explicitly recruit AYA patients and will therefore collect empirical data to bridge the molecular gap between pediatric and adult oncology. The initial pilot study, activated in Feb-2019 across Europe, will recruit 100 AYA patients (aged 12-29 years) with newly diagnosed or relapsed high-grade gliomas and high-grade bone and soft tissue sarcomas. The primary objective of the pilot is to determine feasibility and recruitment rates. Formalin-fixed tumor tissue and whole blood from study participants will be prospectively collected with clinical data and stored centrally at the Integrated BioBank of Luxembourg (IBBL). Whole exome sequencing (WES) of matched tumor and blood, and tumor RNA sequencing and DNA methylation profiling will be performed at the German Cancer Research Center (DKFZ), Heidelberg. Virtual central pathology review of scanned diagnostic slides will be undertaken by an international expert panel, and diagnostic material returned to the participating centers. A multidisciplinary molecular tumor board will release a clinically validated report to referring clinicians within 4-6 weeks after biopsy. SPECTA-AYA constitutes a major opportunity to gain knowledge about the tumor biology of this unique age group. It incorporates notable innovative aspects: AYA specificity, pan-European academic collaboration, centralized biobanking, comprehensive molecular profiling, and virtual central pathology review, among others. SPECTA-AYA will help untangle the tumor particularities of AYAs with cancer and aims to improve their access to novel drugs and personalized medicine. This article is protected by copyright. All rights reserved.


    This article is protected by copyright. All rights reserved.

    KEYWORDS: Adolescents and young adults, high grade glioma, molecular profiling, personalized medicine, sarcoma

    Publikations ID: 31465545
    Quelle: öffnen
     
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