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    Journal of clinical medicine. 2019 Aug 27. pii: jcm8091315. doi: 10.3390/jcm8091315
    Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland.
    Grasl S1,  Janik S2,  Grasl MC3,  Pammer J4,  Formanek M5,  Weinreb I6,  Perez-Ordonez B7,  Hope A8,  Hosni A9,  de Almeida JR10,  Irish J11,  Gilbert R12,  Goldstein DP13,  Erovic BM14
    Author information
    1Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria.
    2Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria.
    3Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, 1090 Vienna, Austria.
    4Clinical Institute of Pathology, Medical University of Vienna, A-1097 Vienna, Austria.
    5Department of Otorhinolaryngology and Phonetics, Hospital of St. John of God, 1020 Vienna, Austria.
    6Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada.
    7Department of Pathology, University Health Network, Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada.
    8Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
    9Department of Radiation Oncology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON M5G 2C4, Canada.
    10Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada.
    11Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada.
    12Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada.
    13Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, ON M5G2C4, Canada. David.Goldstein@uhn.ca.
    14Institute of Head and Neck Diseases, Evangelical Hospital Vienna, 1180 Vienna, Austria. b.erovic@ekhwien.at.
    Abstract

    The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS ( = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69-44.01; = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01-0.37; = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02-0.59; = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.


    KEYWORDS: acinic cell tumor, elective neck dissection, parotid gland

    Publikations ID: 31461946
    Quelle: öffnen
     
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