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| Journal of clinical medicine. 2019 Aug 27. pii: jcm8091315. doi: 10.3390/jcm8091315 |
| Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland. |
| Grasl S1, Janik S2, Grasl MC3, Pammer J4, Formanek M5, Weinreb I6, Perez-Ordonez B7, Hope A8, Hosni A9, de Almeida JR10, Irish J11, Gilbert R12, Goldstein DP13, Erovic BM14 |
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Abstract The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS ( = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69-44.01; = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01-0.37; = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02-0.59; = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes. |
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KEYWORDS: acinic cell tumor, elective neck dissection, parotid gland |
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Publikations ID: 31461946 Quelle: öffnen |
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