Abk�rzung zur Hauptnavigation Abk�rzung zu den Newsmeldungen Abk�rzung zu den Topstories  
  Barrierefreiheit    Kontakt MedUni Wien    Intranet    MedUni Wien - Shop    Universitätsbibliothek    Universitätsklinikum AKH Wien  
 
ccc_logo_en.gif
 
AKH Wien
 
 
Hauptnavigation
  • Livestream 2021
  • Home
  • Über das CCC
    • Allgemeines
    • Leitung der Organisationseinheit
    • CCC-Office Team
    • Kliniken und Partner
    • Qualitätsmanagement
    • Kontakt
  • PatientInnen
    • Covid-19
    • Allgemeines
    • Cancer School
    • Terminvereinbarung
    • Pflegeambulanz
    • PatientInnenvertretung
    • Links
  • Klinischer Bereich
    • Allgemeines
    • CCC Tumorboards
  • Wissenschaft & Forschung
    • Young CCC
    • CCC-ExpertInnenvideos
    • CCC Forschungscluster
    • CCC Units
    • CCC Platforms
    • Translationale Forschung
    • CCC Best Paper Award
    • CCC-TRIO Symposium
    • Kontakt/Links
  • Lehre
    • CCC Cancer School
    • Vienna International Summer School on Clinical and Experimental Oncology - VSSO
    • CCC Excellence Lecture
    • Interdisziplinäre onkologische Ausbildung
    • Klinisch-Praktisches Jahr (KPJ)
    • PhD Programme
    • Postgraduelle Fort- und Weiterbildung
    • Information/Contact
 
 
Subnavigation
    Inhaltsbereich


    Zurück zur Übersicht
    Science (New York, N.Y.). pii: 365/6452/eaau9923. doi: 10.1126/science.aau9923
    Somatic evolution and global expansion of an ancient transmissible cancer lineage.
    Baez-Ortega A1,  Gori K2,  Strakova A3,  Allen JL4,  Allum KM5,  Bansse-Issa L6,  Bhutia TN7,  Bisson JL8,  Briceño C9,  Castillo Domracheva A10,  Corrigan AM11,  Cran HR12,  Crawford JT13,  Davis E14,  de Castro KF15,  B de Nardi A16,  de Vos AP17,  Delgadillo Keenan L18,  Donelan EM19,  Espinoza Huerta AR20,  Faramade IA21,  Fazil M22,  Fotopoulou E23,  Fruean SN24,  Gallardo-Arrieta F25,  Glebova O26,  Gouletsou PG27,  Häfelin Manrique RF28,  Henriques JJGP29,  Horta RS30,  Ignatenko N31,  Kane Y32,  King C33,  Koenig D34,  Krupa A35,  Kruzeniski SJ36,  Kwon YM37,  Lanza-Perea M38,  Lazyan M39,  Lopez Quintana AM40,  Losfelt T41,  Marino G42,  Martínez Castañeda S43,  Martínez-López MF44,  Meyer M45,  Migneco EJ46,  Nakanwagi B47,  Neal KB48,  Neunzig W49,  Ní Leathlobhair M50,  Nixon SJ51,  Ortega-Pacheco A52,  Pedraza-Ordoñez F53,  Peleteiro MC54,  Polak K55,  Pye RJ56,  Reece JF57,  Rojas Gutierrez J58,  Sadia H59,  Schmeling SK60,  Shamanova O61,  Sherlock AG62,  Stammnitz M63,  Steenland-Smit AE64,  Svitich A65,  Tapia Martínez LJ66,  Thoya Ngoka I67,  Torres CG68,  Tudor EM69,  van der Wel MG70,  Viţălaru BA71,  Vural SA72,  Walkinton O73,  Wang J74,  Wehrle-Martinez AS75,  Widdowson SAE76,  Stratton MR77,  Alexandrov LB78,  Martincorena I79,  Murchison EP80
    Author information
    1Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    2Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    3Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    4Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
    5World Vets, Gig Harbor, USA.
    6Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
    7Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, India.
    8Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    9ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.
    10Corozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.
    11St. George's University, True Blue, Grenada.
    12The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.
    13Animal Medical Centre, Belize City, Belize.
    14International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, CA, USA.
    15Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.
    16Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), São Paulo, Brazil.
    17Ladybrand Animal Clinic, Ladybrand, South Africa.
    18Veterinary Clinic Sr. Dog's, Guadalajara, Mexico.
    19Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.
    20World Vets Latin America Veterinary Training Center, Granada, Nicaragua.
    21National Veterinary Research Institute, Vom, Nigeria.
    22Animal Clinic, Mombasa, Kenya.
    23Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.
    24Animal Protection Society of Samoa, Apia, Samoa.
    25Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.
    26Veterinary Clinic BIOCONTROL, Moscow, Russia.
    27Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.
    28Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.
    29OnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.
    30Universidade Vila Velha, Vila Velha, Brazil.
    31Veterinary Clinic Zoovetservis, Kiev, Ukraine.
    32École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.
    33World Vets, Gig Harbor, USA.
    34World Vets, Gig Harbor, USA.
    35Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.
    36World Vets Latin America Veterinary Training Center, Granada, Nicaragua.
    37Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    38St. George's University, True Blue, Grenada.
    39Vetexpert Veterinary Group, Yerevan, Armenia.
    40Veterinary Clinic Lopez Quintana, Maldonado, Uruguay.
    41Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.
    42Department of Veterinary Sciences, University of Messina, Messina, Italy.
    43Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.
    44School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.
    45Touray & Meyer Vet Clinic, Serrekunda, The Gambia.
    46Hillside Animal Hospital, St. Louis, MO, USA.
    47The Kampala Veterinary Surgery, Kampala, Uganda.
    48Asavet Veterinary Charities, Tucson, AZ, USA.
    49World Vets, Gig Harbor, USA.
    50Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    51Vets Beyond Borders, Bylakuppe, India.
    52Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.
    53Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.
    54Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.
    55Four Paws International, Vienna, Austria.
    56Vets Beyond Borders, The Rocks, Australia.
    57Help in Suffering, Jaipur, India.
    58Veterinary Clinic Dr José Rojas, Los Andes, Chile.
    59Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.
    60Corozal Veterinary Clinic, Corozal Town, Belize.
    61Veterinary Clinic Vetmaster, Ramenskoye, Russia.
    62Vets Beyond Borders, The Rocks, Australia.
    63Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    64Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.
    65State Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine.
    66World Vets Latin America Veterinary Training Center, Granada, Nicaragua.
    67Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.
    68Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.
    69Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.
    70Animal Anti Cruelty League, Port Elizabeth, South Africa.
    71Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.
    72Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.
    73Vets Beyond Borders, The Rocks, Australia.
    74Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
    75Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.
    76Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.
    77Wellcome Sanger Institute, Hinxton, UK.
    78Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.
    79Wellcome Sanger Institute, Hinxton, UK.
    80Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. epm27@cam.ac.uk.
    Abstract

    The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution.


    Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

    Publikations ID: 31371581
    Quelle: öffnen
     
    Drucken
     
    ccc_logo_en.gif
    ccc_logo_en.gif
    ccc_logo_en.gif

    Schnellinfo

     
    -- Initiative Krebsforschung / Krebsforschungslauf

    -- Cancer Care
    -- Kliniken und Partner
    -- CCC Cancer School
    -- Young CCC
    -- CCC Tumorboards
    -- CCC Forschungscluster
    -- CCC Units
    -- CCC Platforms
    -- SOPs / Leitlinien
    -- Kontakt
    Zuklappen
     
    Ausklappen
     
     

    Featured

     
     
     
     
     
     
     
     
     
     
     
     
     
    21sextury.org fake hub hd sexy hub eroticax.org
    © MedUni Wien |
     Impressum | Nutzungsbedingungen | Kontakt