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| Diabetes care. 2019 May 21. pii: dc18-2625. doi: 10.2337/dc18-2625. pmc: PMC6609966 |
| Young Children Have Higher Variability of Insulin Requirements: Observations During Hybrid Closed-Loop Insulin Delivery. |
| Dovc K1, Boughton C2, Tauschmann M3, Thabit H4, Bally L5, Allen JM6, Acerini CL7, Arnolds S8, de Beaufort C9, Bergenstal RM10, Campbell F11, Criego A12, Dunger DB13, Elleri D14, Evans ML15, Fröhlich-Reiterer E16, Hofer S17, Kapellen T18, Leelarathna L19, Pieber TR20, Rami-Merhar B21, Shah VN22, Sibayan J23, Wilinska ME24, Hovorka R25 |
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Abstract OBJECTIVE: To quantify age-related variability of insulin needs during day and night closed-loop insulin delivery. RESEARCH DESIGN AND METHODS: We retrospectively analyzed data from hybrid closed-loop studies involving young children (1-6 years old, = 20), children (7-12 years, = 21), adolescents (13-17 years, = 15), and adults (>18 years, = 58) with type 1 diabetes. The coefficient of variation quantified variability of insulin needs during 3 weeks of unrestricted-living hybrid closed-loop use. RESULTS: Data from 2,365 nights and 2,367 days in 114 participants were analyzed. The coefficient of variation of insulin delivery was higher in young children compared with adults (mean difference at nighttime 10.7 percentage points [95% CI 2.9-18.4], = 0.003; daytime 6.4 percentage points [95% CI 2.0-10.9], = 0.002) and compared with adolescents (mean difference at nighttime 10.2 percentage points [95% CI 0.0-20.4], = 0.049; daytime 7.0 percentage points [95% CI 1.1-12.8], = 0.014). CONCLUSIONS: Diabetes management in young children is complicated by higher variability in insulin requirements, supporting fast-track clinical practice adoption of closed-loop in this vulnerable population. |
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© 2019 by the American Diabetes Association. |
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Publikations ID: 31221700 Quelle: öffnen |
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