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| Carbohydrate polymers. 2019 Mar 18. pii: S0144-8617(19)30332-7. doi: 10.1016/j.carbpol.2019.03.060 |
| Self-assembled high molecular weight inulin nanoparticles: Enzymatic synthesis, physicochemical and biological properties. |
| Jiménez-Sánchez M1, Pérez-Morales R2, Goycoolea FM3, Mueller M4, Praznik W5, Loeppert R6, Bermúdez-Morales V7, Zavala-Padilla G8, Ayala M9, Olvera C10 |
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Abstract Inulin has interesting physicochemical and functional properties, and therefore a wide range of applications in the food and medical industries. It has gained great traction due to its ability to form nanoparticles and its possible application as nanovehicle for drug delivery. In this work, we demonstrated that the enzymatically-synthesized high molecular weight (HMW) inulin forms stable spherical nanoparticles with an average diameter of 112 ± 5 nm. The self-assemblage of HMW inulin nanoparticles is carried out during enzymatic synthesis of the polymer, and become detectable after a certain critical aggregation concentration (CAC) is reached. Both, the CAC and nanoparticle size are influenced by the reaction temperature. These nanoparticles are not toxic for peripheral blood mononuclear cells, at concentrations below 200 μg/mL; no significant prebiotic potential was detected in cultures of 13 probiotic strains. This work contributes to a better understanding of the formation of HMW inulin nanoparticles and their biological properties. |
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Copyright © 2019 Elsevier Ltd. All rights reserved. |
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KEYWORDS: Enzymatic synthesis, Fructan, Inulin, Inulosucrase, Polysaccharide nanoparticles |
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Publikations ID: 30981341 Quelle: öffnen |
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