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| Open forum infectious diseases. 2017 Dec 22. doi: 10.1093/ofid/ofx275. pii: ofx275. pmc: PMC5772402 |
| Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study. |
| Castillo-Mancilla JR1, Phillips AN2, Neaton JD3, Neuhaus J4, Collins S5, Mannheimer S6, Pett S7, Touzeau-Römer V8, Polizzotto MN9, Lundgren JD10, Gardner EM11 |
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Abstract Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352. |
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KEYWORDS: SMART study, adherence, antiretroviral therapy, inflammation |
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Publikations ID: 29362724 Quelle: öffnen |
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