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    Nature genetics. 2017 Oct 23. pii: ng.3785. doi: 10.1038/ng.3785
    Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
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    Author information
    1Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
    2Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    3Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    4Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    5Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    6Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA.
    7Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
    8Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.
    9Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.
    10Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    11Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    12Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
    13Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    14Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    15Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    16Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    17Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
    18Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    19Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
    20Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS, Padua, Italy.
    21Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    22Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois, USA.
    23Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    24Personalised Medicine Team, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    25Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    26Roswell Park Cancer Institute, Buffalo, New York, USA.
    27Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.
    28Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
    29Department of Epidemiology, University of California, Irvine, Irvine, California, USA.
    30N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
    31Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    32Institute of Clinical Molecular Biology / Department of Gynecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany.
    33Department of Public Health Sciences and Cancer Research Institute, Queen's University, Kingston, Ontario, Canada.
    34Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
    35Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
    36Department of Medical Genetics, University Medical Center Utrecht, Utrecht, the Netherlands.
    37Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy.
    38McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada.
    39Department of Medical Oncology, University Hospital, Vall d'Hebron, Barcelona, Spain.
    40Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.
    41Bâtiment Cheney D, Centre Léon Bérard, Lyon, France.
    42Laboratory of Cell Biology, Department of Pathology, Landspitali, Reykjavik, Iceland.
    43Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    44Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    45Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    46Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    47Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
    48Human Genotyping Unit -Centro Nacional de Genotipado (CEGEN), Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
    49Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation.
    50Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
    51Université Clermont Auvergne, INSERM, U1240, Imagerie Moléculaire et Stratégies Théranostiques, Centre Jean Perrin, Clermont-Ferrand, France.
    52Clinical Cancer Genetics, City of Hope, Duarte, California, USA.
    53Department of Clinical Genetics, Maastricht University Medical Center, Maastricht, the Netherlands.
    54Department of Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    55Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
    56City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA.
    57Vesalius Research Center, VIB, Leuven, Belgium.
    58N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus.
    59Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark.
    60Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
    61Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy.
    62Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
    63Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
    64Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    65Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    66Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
    67Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    68Gustave Roussy, Biopathology Department, Villejuif, France.
    69Department of Clinical Genetics, Royal Devon and Exeter Hospital, Exeter, UK.
    70Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
    71Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
    72Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
    73Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Girona, Spain.
    74Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
    75Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
    76Department of Medicine, Huntsman Cancer Institute, Salt Lake City, Utah, USA.
    77Center for Genomic Medicine, Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, New Hampshire, USA.
    78Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
    79Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain.
    80Section of Molecular Genetics, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy.
    81Research Department, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
    82Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    83Gustave Roussy, Biopathology Department, Villejuif, France.
    84Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servizo Galego de Saúde SERGAS, Santiago de Compostela, Spain.
    85Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
    86Oncology and Genetics Unit, Instituto de Investigación Biomédica (IBI) de Orense-Pontevedra-Vigo, Xerencia de Xestión Integrada de Vigo, Servizo Galego de Saúde SERGAS, Vigo, Spain.
    87Centre François Baclesse, Caen, France.
    88Service de Génétique Oncologique and INSERM U830, Institut Curie, Paris, France - Université Paris Descartes, Sorbonne Paris Cité.
    89Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    90Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
    91Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    92Division of Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA.
    93Unité de Recherche en Santé des Populations, Centre des Maladies du Sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec City, Québec, Canada.
    94Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
    95Center for Medical Genetics, Ghent University, Ghent, Belgium.
    96Westmead Institute for Medical Research, University of Sydney, Sydney, New South Wales, Australia.
    97Huntsman Cancer Institute, Salt Lake City, Utah, USA.
    98Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    99Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, UK.
    100Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
    101Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
    102Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France.
    103Academic Unit of Molecular Oncology, Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK.
    104Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
    105Academic Unit of Pathology, Department of Neuroscience, University of Sheffield, Sheffield, UK.
    106Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    107Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    108Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    109Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA.
    110Bâtiment Cheney D, Centre Léon Bérard, Lyon, France.
    111Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    112Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK.
    113Center for Medical Genetics, Ghent University, Ghent, Belgium.
    114Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
    115Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    116Oncogenetics Group, Vall d'Hebron Institute of Oncology (VHIO), Clinical and Molecular Genetics Area, Vall d'Hebron University Hospital, Barcelona, Spain.
    117Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
    118Department of Gynecology and Obstetrics, Ludwig Maximilians University of Munich, Munich, Germany.
    119Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    120Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    121Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Arcadia, South Africa.
    122Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
    123Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
    124Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.
    125Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
    126Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.
    127Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    128Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
    129Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK.
    130Institute of Human Genetics, University of Münster, Münster, Germany.
    131Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
    132Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
    133Department of Clinical Genetics, Lund University Hospital, Lund, Sweden.
    134Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    135Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    136Institute of Human Genetics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
    137Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    138Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
    139Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    140Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    141Genetics Department, Dijon University Hospital, Dijon, France.
    142Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
    143Institute of Medical Genetics and Applied Genomics, University of Tübingen, Tübingen, Germany.
    144Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
    145Institute for Medical Biometrics and Epidemiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    146Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
    147Department of Breast Surgery, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
    148Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Québec, Canada.
    149Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.
    150School of Public Health, Curtin University, Perth, Western Australia, Australia.
    151Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    152Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    153Clinical Cancer Genetics Laboratory, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    154Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
    155Division of Cancer Prevention and Control Research, Jonsson Comprehensive Cancer Center, Schools of Medicine and Public Health, University of California, Los Angeles, Los Angeles, California, USA.
    156Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
    157Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    158Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain.
    159Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain.
    160Epidemiology Research Program, American Cancer Society, Atlanta, Georgia, USA.
    161Service de Génétique Oncologique and INSERM U830, Institut Curie, Paris, France - Université Paris Descartes, Sorbonne Paris Cité.
    162Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.
    163Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece.
    164Department of Clinical Genetics, Rigshospitalet, Copenhagen, Denmark.
    165Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
    166Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
    167Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
    168Department of Medicine, McGill University, Montréal, Québec, Canada.
    169Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.
    170Human Genotyping Unit -Centro Nacional de Genotipado (CEGEN), Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
    171Department of Obstetrics and Gynecology, Ohio State University James Comprehensive Cancer Center, Columbus, Ohio, USA.
    172Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
    173Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
    174Department of Surgery, Oulu University Hospital, University of Oulu, Oulu, Finland.
    175Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    176Centre de Recherche du Centre Hospitalier de Université de Montréal (CHUM), Montréal, Québec, Canada.
    177Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.
    178Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
    179Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    180Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
    181Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
    182Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    183Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    184Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
    185Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    186McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada.
    187Department of Biostatistics and Epidemiology, University of Massachusetts, Amherst, Amherst, Massachusetts, USA.
    188Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
    189Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    190Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
    191Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
    192Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    193Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Erlangen, Germany.
    194Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
    195Institute of Genetic Medicine, Centre for Life, Newcastle-upon-Tyne Hospitals NHS Trust, Newcastle-upon-Tyne, UK.
    196School of Population Health, University of Western Australia, Perth, Western Australia, Australia.
    197Cancer Genomics Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    198Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
    199Medical Genetics Unit, St George's, University of London, London, UK.
    200Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
    201Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
    202Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
    203Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
    204Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
    205Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    206Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    207Center for Medical Genetics, NorthShore University HealthSystem, Evanston, Illinois, USA.
    208Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    209Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    210N.N. Petrov Institute of Oncology, St. Petersburg, Russian Federation.
    211Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.
    212Division of Epidemiology, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
    213Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
    214Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    215Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
    216State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania.
    217Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany.
    218Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark.
    219Department of Epidemiology, Cancer Prevention Institute of California, Fremont, California, USA.
    220Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
    221Cancer Genomics Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    222Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
    223Department of Oncology, Oulu University Hospital, University of Oulu, Oulu, Finland.
    224Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    225Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    226Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    227Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
    228Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
    229Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
    230School of Medicine, National University of Ireland, Galway, Ireland.
    231Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
    232Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
    233Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    234Institute of Biochemistry and Genetics, Ufa Scientific Center of the Russian Academy of Sciences, Ufa, Russian Federation.
    235Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    236Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.
    237Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada.
    238Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
    239Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
    240Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Oslo, Norway.
    241Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
    242Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong.
    243Department of Pathology, University Hospital of Region Zealand, Division Slagelse, Slagelse, Denmark.
    244Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan, Israel.
    245Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
    246Vesalius Research Center, VIB, Leuven, Belgium.
    247Clalit National Cancer Control Center, Haifa, Israel.
    248Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
    249Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
    250University of Hawaii Cancer Center, Honolulu, Hawaii, USA.
    251Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    252Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    253Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    254Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.
    255Department of Surgery, Soonchunhyang University and Hospital, Seoul, Republic of Korea.
    256Clalit National Cancer Control Center, Haifa, Israel.
    257Institut Curie, Paris, France.
    258Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    259Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona, USA.
    260Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    261Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
    262Department of Cancer Epidemiology and Prevention, M. Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
    263Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
    264German Breast Group, Neu Isenburg, Germany.
    265Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
    266Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA.
    267Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    268Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    269Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    270Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
    271Southampton Clinical Trials Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
    272Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
    273Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Macedonia.
    274Division of Public Health Sciences, Epidemiology Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
    275Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy.
    276Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
    277Department of Oncology, Pathology, Karolinska Institutet, Stockholm, Sweden.
    278Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
    279Moores Cancer Center, University of California, San Diego, La Jolla, California, USA.
    280Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
    281Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece.
    282Lyon Neuroscience Research Center-CRNL, INSERM U1028, CNRS UMR 5292, University of Lyon, Lyon, France.
    283Anatomical Pathology, Alfred Hospital, Melbourne, Victoria, Australia.
    284Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
    285Servicio de Anatomía Patológica, Hospital Monte Naranco, Oviedo, Spain.
    286Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    287Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
    288NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, New York, USA.
    289School of Medicine, National University of Ireland, Galway, Ireland.
    290Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Victoria, Australia.
    291Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV), IRCCS, Padua, Italy.
    292Institute of Population Health, University of Manchester, Manchester, UK.
    293Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
    294Université Paris Sorbonne Cité, INSERM UMRS 1147, Paris, France.
    295City of Hope Clinical Cancer Genomics Community Research Network, Duarte, California, USA.
    296Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
    297Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA.
    298Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
    299Leuven Multidisciplinary Breast Center, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
    300Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
    301Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
    302Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark.
    303Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
    304Department of Medicine, University of California, San Francisco,San Francisco, California, USA.
    305Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
    306Center for Clinical Cancer Genetics and Global Health, University of Chicago, Chicago, Illinois, USA.
    307Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
    308Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
    309West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK.
    310Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
    311Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
    312Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO), Madrid, Spain.
    313University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico, USA.
    314Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy.
    315Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
    316Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
    317Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Western Australia, Australia.
    318Section of Molecular Diagnostics, Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.
    319Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy.
    320Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
    321Servicio de Cirugía General y Especialidades, Hospital Monte Naranco, Oviedo, Spain.
    322IFOM, FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
    323Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.
    324Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    325Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA.
    326Clalit National Cancer Control Center, Haifa, Israel.
    327Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Macedonian Academy of Sciences and Arts, Skopje, Macedonia.
    328Center for Medical Genetics, Ghent University, Ghent, Belgium.
    329South East of Scotland Regional Genetics Service, Western General Hospital, Edinburgh, UK.
    330Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
    331Department of Biomedical Sciences, Faculty of Science and Technology, University of Westminster, London, UK.
    332Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russian Federation.
    333Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    334ProCURE, Catalan Institute of Oncology, IDIBELL (Bellvitge Biomedical Research Institute), Barcelona, Spain.
    335Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
    336Department of Gynecology and Obstetrics, Ludwig Maximilians University of Munich, Munich, Germany.
    337Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy.
    338Section of Cancer Genetics, The Institute of Cancer Research, London, UK.
    339Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
    340Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.
    341Clalit National Cancer Control Center, Haifa, Israel.
    342Clalit National Cancer Control Center, Haifa, Israel.
    343Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    344Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
    345Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
    346Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, Illinois, USA.
    347Medical Oncology Department, CIBERONC, Hospital Clínico San Carlos, Madrid, Spain.
    348Center for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    349Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
    350Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    351Institute of Pathology, Staedtisches Klinikum Karlsruhe, Karlsruhe, Germany.
    352Hereditary Cancer Clinic, University Hospital of Heraklion, Heraklion, Greece.
    353Department of Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
    354Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
    355National Cancer Institute, Bangkok, Thailand.
    356Department of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, USA.
    357Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
    358Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
    359Research Oncology, Guy's Hospital, King's College London, London, UK.
    360Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
    361Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany.
    362Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
    363Division of Molecular Medicine, Pathology North, John Hunter Hospital, Newcastle, New South Wales, Australia.
    364Section of Cancer Genetics, The Institute of Cancer Research, London, UK.
    365Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
    366Department of Medical Oncology, Family Cancer Clinic, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
    367Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    368Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.
    369School of Public Health, China Medical University, Taichung, Taiwan.
    370Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    371Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    372Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
    373Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
    374North East Thames Regional Genetics Service, Great Ormond Street Hospital for Children NHS Trust, London, UK.
    375Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.
    376National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
    377Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
    378Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
    379Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    380Saarland Cancer Registry, Saarbrücken, Germany.
    381Service de Génétique Oncologique and INSERM U830, Institut Curie, Paris, France - Université Paris Descartes, Sorbonne Paris Cité.
    382Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
    383Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
    384Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
    385Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
    386National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA.
    387Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    388Department of Obstetrics and Gynaecology and Comprehensive Cancer Centre, Medical University of Vienna, Vienna, Austria.
    389Epidemiology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
    390Molecular Genetics Laboratory, Clinical Genetics Service, Cruces University Hospital and BioCruces Health Research Institute, Barakaldo, Spain.
    391Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
    392Cancer Research Malaysia, Subang Jaya, Malaysia.
    393Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA.
    394McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada.
    395Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.
    396Department of Cancer Epidemiology, Clinical Cancer Registry, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
    397Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
    398Ospedale di Circolo ASST Settelaghi, Varese, Italy.
    399Latvian Biomedical Research and Study Centre, Riga, Latvia.
    400Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, Québec, Canada.
    401Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, USA.
    402Department of Surgery, Leiden University Medical Center, Leiden, the Netherlands.
    403Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
    404Center for Cancer Epidemiology and Prevention, University of Chicago, Chicago, Illinois, USA.
    405Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
    406Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.
    407Cancer and Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif, France.
    408Hereditary Cancer Clinic, Department of Medical Oncology, Prince of Wales Hospital, Randwick, New South Wales, Australia.
    409Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
    410Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
    411Frauenklinik der Stadtklinik Baden Baden, Baden Baden, Germany.
    412Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
    413Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
    414Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    415Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
    416Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Arcadia, South Africa.
    417Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) AOU San Martino, IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
    418Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany.
    419Fundación Pública Galega de Medicina Xenómica, Servizo Galego de Saúde SERGAS, Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain.
    420Unit of Functional Onco-genomics and Genetics, CRO Aviano, National Cancer Institute, Aviano, Italy.
    421Clinical Genetics Research Laboratory, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    422McGill University and Génome Québec Innovation Centre, Montréal, Québec, Canada.
    423Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    424Oxford Regional Genetics Service, Churchill Hospital, Oxford, UK.
    425Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
    426Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany.
    427Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
    428Biostatistics and Computational Biology Branch, National Institute of Environmental Health Sciences, US National Institutes of Health, Research Triangle Park, North Carolina, USA.
    429Clinical Cancer Genetics, City of Hope, Duarte, California, USA.
    430Department of Oncology, Pathology, Karolinska Institutet, Stockholm, Sweden.
    431Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
    432Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA.
    433Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
    434Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    435Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, University of Oulu, Oulu, Finland.
    436Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    437Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    438Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
    439Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
    440Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
    441Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico), Istituto Nazionale dei Tumori (INT), Milan, Italy.
    442Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
    443Cancer Genomics Research Laboratory (CGR), Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
    444Department of Epidemiology, University of California, Irvine, Irvine, California, USA.
    445Department of Medicine, Institute for Human Genetics, UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.
    446Ospedale di Circolo ASST Settelaghi, Varese, Italy.
    447Genomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servizo Galego de Saúde SERGAS, Santiago de Compostela, Spain.
    448Translational Cancer Research Area, University of Eastern Finland, Kuopio, Finland.
    449Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
    450Department of Genetics, Portuguese Oncology Institute, Porto, Portugal.
    451Curtin UWA Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Perth, Western Australia, Australia.
    452Clinical Genetics Research Laboratory, Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
    453Department of Molecular Medicine, University La Sapienza, Rome, Italy.
    454Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
    455Department of Clinical Genetics, Odense University Hospital, Odense, Denmark.
    456Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    457Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
    458Center for Familial Breast and Ovarian Cancer, University Hospital of Cologne, Cologne, Germany.
    459Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.
    460Donnelly Centre, University of Toronto, Toronto, Ontario, Canada.
    461Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    462Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
    463Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    464Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
    465Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
    466Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
    467Division of Molecular Pathology, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
    468Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
    469Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Québec, Canada.
    Abstract

    Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease. We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 × 10(-8) with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.


    Publikations ID: 29058716
    Quelle: öffnen
     
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