Publikationen

Subnavigation

Inhaltsbereich

Zurück zur Übersicht

Clinical and translational allergy. 2017 Sep 17. doi: 10.1186/s13601-017-0169-4. pii: 169. pmc: PMC5604509

Peak nasal inspiratory flow as outcome for provocation studies in allergen exposure chambers: a GA(2)LEN study.

Boelke G¹, Berger U², Bergmann KC³, Bindslev-Jensen C⁴, Bousquet J⁵, Gildemeister J⁶, Jutel M⁷, Pfaar O⁸, Sehlinger T⁹, Zuberbier T¹⁰

Author information

¹Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Center-Charité, Berlin, Germany.
²Department of Otorhinolaryngology, Aerobiology and Pollen Information Research Unit, Medical University of Vienna, Vienna, Austria.
³Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Center-Charité, Berlin, Germany.
⁴Department of Dermatology and Allergy Centre, Odense University Hospital, Odense, Denmark.
⁵CHRU, Montpellier University Hospital Center, Montpellier, France.
⁶Mobile Chamber Experts GmbH, Berlin, Germany.
⁷ALL-MED Medical Research Institute, Wrocław, Poland.
⁸Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
⁹Bluestone Technology GmbH, Woerrstadt, Germany.
¹⁰Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Dermatology and Allergy, Allergy-Center-Charité, Berlin, Germany.

Abstract

BACKGROUND: The GA(2)LEN chamber has been developed as a novel mobile allergen exposure chamber (AEC) allowing standardized multicenter trials in allergy. Hitherto, subjective nasal symptom scores have been the most often used outcome parameter, but in standardized modern trials objective parameters are preferred. Despite its practicability, the objective parameter peak nasal inspiratory flow (PNIF) has been rarely used for allergy trials in the setting of allergen exposure chambers. This study aims to evaluate PNIF as an outcome parameter for provocation studies in AECs.

METHODS: In a randomized controlled blinded setting subjects suffering from allergic rhinitis were exposed to grass pollen, birch pollen, house dust mite and/or placebo in the GA(2)LEN chamber. Different allergen concentrations were used to evaluate symptom severities. Patients had to perform PNIF before and every 30 min during a challenge using a portable PNIF meter.

RESULTS: 86 subjects participated in 203 challenges, altogether. House dust mite provocations caused the greatest reduction in PNIF values, followed by grass pollen and birch pollen. Provocations with every allergen or pollen concentration led to a significant decrease (p < 0.05) in PNIF compared to baseline. Furthermore, positive correlations were obtained between PNIF and peak expiratory flow, height and weight, and inverse correlations between PNIF and total nasal symptom score, nasal congestion score and visual analog scale of overall subjective symptoms.

CONCLUSION: PNIF is a helpful and feasible tool for conducting provocation trials with allergens, especially grass pollen and house dust mite, in an AEC.

KEYWORDS: Allergen exposure chamber (AEC), Allergy trial, GA2LEN chamber, Peak nasal inspiratory flow (PNIF), Provocation study

Publikations ID: 28932387
Quelle: öffnen

Drucken

Schnellinfo

-- Initiative Krebsforschung / Krebsforschungslauf

-- Cancer Care
-- Kliniken und Partner
-- CCC Cancer School
-- Young CCC
-- CCC Tumorboards
-- CCC Forschungscluster
-- CCC Units
-- CCC Platforms
-- SOPs / Leitlinien
-- Kontakt

Zuklappen

Ausklappen

Schnellinfo

Featured