Zurück zur Übersicht
| Oncogene. 2017 Sep 18. pii: onc2017341. doi: 10.1038/onc.2017.341 |
| A slow-cycling subpopulation of melanoma cells with highly invasive properties. |
| Perego M1, Maurer M2, Wang JX3, Shaffer S4, Müller AC5, Parapatics K6, Li L7, Hristova D8, Shin S9, Keeney F10, Liu S11, Xu X12, Raj A13, Jensen JK14, Bennett KL15, Wagner SN16, Somasundaram R17, Herlyn M18 |
 Author information
|
|
Abstract Melanoma is a heterogeneous tumor with different subpopulations showing different proliferation rates. Slow-cycling cells were previously identified in melanoma, but not fully biologically characterized. Using the label-retention method, we identified a subpopulation of slow-cycling cells, defined as label-retaining cells (LRC), with strong invasive properties. We demonstrate through live imaging that LRC are leaving the primary tumor mass at a very early stage and disseminate to peripheral organs. Through global proteome analyses, we identified the secreted protein SerpinE2/protease nexin-1 as causative for the highly invasive potential of LRC in melanomas.Oncogene advance online publication, 18 September 2017; doi:10.1038/onc.2017.341. |
|
Publikations ID: 28925403 Quelle: öffnen |
Author information
Schnellinfo
-- Cancer Care
-- Kliniken und Partner
-- CCC Cancer School
-- Young CCC
-- CCC Tumorboards
-- CCC Forschungscluster
-- CCC Units
-- CCC Platforms
-- SOPs / Leitlinien
-- Kontakt
Featured
