The European respiratory journal. 2017 Aug 31. pii: 50/2/1700936. doi: 10.1183/13993003.00936-2017 |
Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study. |
Walsh SLF1, Maher TM2, Kolb M3, Poletti V4, Nusser R5, Richeldi L6, Vancheri C7, Wilsher ML8, Antoniou KM9, Behr J10, Bendstrup E11, Brown K12, Calandriello L13, Corte TJ14, Cottin V15, Crestani B16, Flaherty K17, Glaspole I18, Grutters J19, Inoue Y20, Kokosi M21, Kondoh Y22, Kouranos V23, Kreuter M24, Johannson K25, Judge E26, Ley B27, Margaritopoulos G28, Martinez FJ29, Molina-Molina M30, Morais A31, Nunes H32, Raghu G33, Ryerson CJ34, Selman M35, Spagnolo P36, Taniguchi H37, Tomassetti S38, Valeyre D39, Wijsenbeek M40, Wuyts W41, Hansell D42, Wells A43 |
Abstract We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index.A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75).Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts. |
Copyright ©ERS 2017. |
Publikations ID: 28860269 Quelle: öffnen |