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    Journal of the European Academy of Dermatology and Venereology : JEADV. 2017 Aug 9. doi: 10.1111/jdv.14458
    European Dermatology Forum S1-guideline on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: localized scleroderma, systemic sclerosis and overlap syndromes.
    Knobler R1,  Moinzadeh P2,  Hunzelmann N3,  Kreuter A4,  Cozzio A5,  Mouthon L6,  Cutolo M7,  Rongioletti F8,  Denton CP9,  Rudnicka L10,  Frasin LA11,  Smith V12,  Gabrielli A13,  Aberer E14,  Bagot M15,  Bali G16,  Bouaziz J17,  Braae Olesen A18,  Foeldvari I19,  Frances C20,  Jalili A21,  Just U22,  Kähäri V23,  Kárpáti S24,  Kofoed K25,  Krasowska D26,  Olszewska M27,  Orteu C28,  Panelius J29,  Parodi A30,  Petit A31,  Quaglino P32,  Ranki A33,  Sanchez Schmidt JM34,  Seneschal J35,  Skrok A36,  Sticherling M37,  Sunderkötter C38,  Taieb A39,  Tanew A40,  Wolf P41,  Worm M42,  Wutte NJ43,  Krieg T44
    Author information
    1Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    2Department of Dermatology and Venereology, University Hospital of Cologne, Cologne, Germany.
    3Department of Dermatology and Venereology, University Hospital of Cologne, Cologne, Germany.
    4Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Klinik Oberhausen, University Witten-Herdecke, Oberhausen, Germany.
    5Department of Dermatology, Venereology and Allergology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
    6Service de Médecine Interne, Centre de référence maladies rares: vascularites et sclérodermie systémique, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France.
    7Research Laboratories and Academic Division of Clinical Rheumatology, IRCCS San Martino, University Medical School of Genoa, Genoa, Italy.
    8Dermatology Unit, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
    9Division of Medicine, Centre for Rheumatology, University College London, London, UK.
    10Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
    11Dermatology Unit, Hospital of Lecco, Lecco, Italy.
    12Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.
    13Department of Clinical and Molecular Science, Università Politecnica delle Marche, Ancona, Italy.
    14Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    15Department of Dermatology, Hôpital Saint-Louis, Hôpitaux Universitaires, Paris, France.
    16Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
    17Department of Dermatology, Hôpital Saint-Louis, Hôpitaux Universitaires, Paris, France.
    18Department of Dermatology, University Hospital of Aarhus, Aarhus, Denmark.
    19Hamburg Centre for Pediatric and Adolescent Rheumatology, Schön Klinik Hamburg Eilbek, Hamburg, Germany.
    20Department of Dermatology and Allergology, Hôpital Tenon, Assistance Publique Hôpitaux de Paris, Université Pierre et Marie Curie, Paris, France.
    21Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    22Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    23Department of Dermatology and Venereology, Turku University Hospital and University of Turku, Turku, Finland.
    24Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.
    25Department of Dermato-Allergology, Herlev and Gentofte University Hospital, Copenhagen, Denmark.
    26Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Lublin, Poland.
    27Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
    28Department of Dermatology, Connective Tissue Diseases Service, Royal Free Hospital, London, UK.
    29Department of Dermatology, Allergology and Venereology, University of Helsinki, and Skin and Allergy Hospital, Helsinki University Central Hospital, Helsinki, Finland.
    30Department of Dermatology, IRCCS San Martino, University Medical School of Genoa, Genoa, Italy.
    31Department of Dermatology, Hôpital Saint-Louis, Hôpitaux Universitaires, Paris, France.
    32Department of Medical Sciences, University of Turin, Turin, Italy.
    33Department of Dermatology, Allergology and Venereology, Inflammation Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
    34Department of Dermatology, Hospital del Mar-Parc de Salut Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
    35Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Saint-Andre, University of Bordeaux, Bordeaux, France.
    36Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.
    37Department of Dermatology, University Hospital of Erlangen, Erlangen, Germany.
    38Department of Dermatology and Venereology, University Hospital Halle, Halle (Saale), Germany.
    39Department of Dermatology and Pediatric Dermatology, National Centre for Rare Skin Disorders, Hôpital Saint-Andre, University of Bordeaux, Bordeaux, France.
    40Department of Dermatology, Medical University of Vienna, Vienna, Austria.
    41Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    42Department of Dermatology, Venereology and Allergology, University Hospital Charité - Universitätsmedizin Berlin, Berlin, Germany.
    43Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.
    44Department of Dermatology and Venereology, University Hospital of Cologne, Cologne, Germany.
    Abstract

    The term 'sclerosing diseases of the skin' comprises specific dermatological entities, which have fibrotic changes of the skin in common. These diseases mostly manifest in different clinical subtypes according to cutaneous and extracutaneous involvement and can sometimes be difficult to distinguish from each other. The present guideline focuses on characteristic clinical and histopathological features, diagnostic scores and the serum autoantibodies most useful for differential diagnosis. In addition, current strategies in the first- and advanced-line therapy of sclerosing skin diseases are addressed in detail. Part 1 of this guideline provides clinicians with an overview of the diagnosis and treatment of localized scleroderma (morphea), and systemic sclerosis including overlap syndromes of systemic sclerosis with diseases of the rheumatological spectrum.


    © 2017 European Academy of Dermatology and Venereology.

    Publikations ID: 28792092
    Quelle: öffnen
     
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