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| Neuro-oncology. 2017 Apr 9. pii: 3038141. doi: 10.1093/neuonc/now241 |
| Diagnosis and treatment of brain metastases from solid tumors: guidelines from the European Association of Neuro-Oncology (EANO). |
| Soffietti R1, Abacioglu U2, Baumert B3, Combs SE4, Kinhult S5, Kros JM6, Marosi C7, Metellus P8, Radbruch A9, Villa Freixa SS10, Brada M11, Carapella CM12, Preusser M13, Le Rhun E14, Rudà R15, Tonn JC16, Weber DC17, Weller M18 |
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1Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.).
2Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 3Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 4Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 5Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 6Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 7Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 8Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 9Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 10Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 11Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 12Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 13Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 14Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 15Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 16Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 17Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). 18Department of Neuro-Oncology, University and City of Health and Science Hospital, Turin, Italy (R.S., R.R.); Department of Radiation Oncology, Neolife Medical Center, Istanbul, Turkey (U.A.); Department of Radiation-Oncology, MediClin Robert-Janker-Klinik, Bonn, Germany (B.B.); Department of Innovative Radiation Oncology and Radiation Sciences, Munich, Germany (S.E.C.); Department of Oncology, Skane University Hospital, Lund, Sweden (S.K.); Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands (J.M.K.); Department of Internal Medicine, Division of Oncology, Medical University, Vienna, Austria (C.M., P.M.); Department of Neurosurgery, Clairval Hospital Center, Generale de Santé, Marseille, France (P.M.); Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany (A.R.); Department of Radiation Oncology, Institut Català d'Oncologia, Hospital Universitari Germans Trias i Pujol, Badalona, Spain (S.S.V.F.); Department of Molecular and Clinical Cancer Medicine & Radiation Oncology, Liverpool, United Kingdom (M.B.); Department of Neuroscience, Division of Neurosurgery, Regina Elena Nat Cancer Institute, Rome, Italy (C.M.C.); Department of Neurosurgery, Neuro-oncology, University Hospital, Lille, France (E.L.); Department of Neurosurgery, University of Munich LMU, Munich, Germany (J.C.T.); Centre for Proton Therapy, Paul Scherrer Institute, Villigen, Switzerland (D.C.W.); Department of Neurology, University Hospital Zurich, Zurich, Switzerland (M.W.). |
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Abstract The management of patients with brain metastases has become a major issue due to the increasing frequency and complexity of the diagnostic and therapeutic approaches. In 2014, the European Association of Neuro-Oncology (EANO) created a multidisciplinary Task Force to draw evidence-based guidelines for patients with brain metastases from solid tumors. Here, we present these guidelines, which provide a consensus review of evidence and recommendations for diagnosis by neuroimaging and neuropathology, staging, prognostic factors, and different treatment options. Specifically, we addressed options such as surgery, stereotactic radiosurgery/stereotactic fractionated radiotherapy, whole-brain radiotherapy, chemotherapy and targeted therapy (with particular attention to brain metastases from non-small cell lung cancer, melanoma and breast and renal cancer), and supportive care. |
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© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
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KEYWORDS: brain metastases, chemotherapy, neuroimaging, neuropathology, stereotactic radiosurgery/stereotactic fractionated radiotherapy, supportive care, surgery, targeted therapy, whole-brain radiation therapy |
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Publikations ID: 28391295 Quelle: öffnen |
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