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| Occupational and environmental medicine. 2016 Jun 16. pii: oemed-2016-103597. doi: 10.1136/oemed-2016-103597 |
| Night shift work and stomach cancer risk in the MCC-Spain study. |
| Gyarmati G1, Turner MC2, Castaño-Vinyals G3, Espinosa A4, Papantoniou K5, Alguacil J6, Costas L7, Pérez-Gómez B8, Martin Sanchez V9, Ardanaz E10, Moreno V11, Gómez-Acebo I12, Fernández-Tardon G13, Villanueva Ballester V14, Capelo R15, Chirlaque MD16, Santibáñez M17, Pollán M18, Aragonés N19, Kogevinas M20 |
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Abstract OBJECTIVES: Night shift work has been classified as a probable human carcinogen by the International Agency for Research on Cancer, based on experimental studies and limited evidence on human breast cancer risk. Evidence at other cancer sites is scarce. We evaluated the association between night shift work and stomach cancer risk in a population-based case-control study. METHODS: A total of 374 incident stomach adenocarcinoma cases and 2481 population controls were included from the MCC-Spain study. Detailed data on lifetime night shift work were collected including permanent and rotating shifts, and their cumulative duration (years). Adjusted unconditional logistic regression models were used in analysis. RESULTS: A total of 25.7% of cases and 22.5% of controls reported ever being a night shift worker. There was a weak positive, non-significant association between ever having had worked for at least 1 year in permanent night shifts and stomach cancer risk compared to never having worked night shifts (OR=1.2, 95% CI 0.9 to 1.8). However, there was an inverse 'U' shaped relationship with cumulative duration of permanent night shifts, with the highest risk observed in the intermediate duration category (OR 10-20 years=2.0, 95% CI 1.1 to 3.6) (p for trend=0.19). There was no association with ever having had worked in rotating night shifts (OR=0.9, 95% CI 0.6 to 1.2) and no trend according to cumulative duration (p for trend=0.68). CONCLUSION: We found no clear evidence concerning an association between night shift work and stomach cancer risk. |
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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ |
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KEYWORDS: Night shift work, Spain, case-control study, stomach cancer |
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Publikations ID: 27312400 Quelle: öffnen |
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