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| The British journal of dermatology. 2015 Jul 25. doi: 10.1111/bjd.14045 |
| The BRAAFF checklist: a new dermoscopic algorithm for diagnosing acral melanoma. |
| Lallas A1, Kyrgidis A2, Koga H3, Moscarella E4, Tschandl P5, Apalla Z6, Di Stefani A7, Ioannides D8, Kittler H9, Kobayashi K10, Lazaridou E11, Longo C12, Phan A13, Saida T14, Tanaka M15, Thomas L16, Zalaudek I17, Argenziano G18 |
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Abstract BACKGROUND: The parallel ridge pattern (PRP) is considered as the dermoscopic hallmark of acral melanoma (AM). However, it was recently shown that approximately one third of AM do not display dermoscopically a PRP, rendering their detection more troublesome. OBJECTIVE: To investigate the diagnostic accuracy of dermoscopic criteria for the diagnosis of AM. METHODS: Dermoscopic images of consecutive cases of histopathologically diagnosed AMs and acral nevi with histopathologic diagnosis or with at least 1 year of follow up were evaluated by 3 independent investigators for the presence of pre-defined criteria. Crude odds ratios, adjusted odds ratios and corresponding 95% confidence intervals were calculated by univariate and multivariate logistic regression, respectively. ROC curves were used to choose among competing classification schemes. RESULTS: A total of 603 lesions (472 nevi and 131 AMs) were included in the study. A scoring system (named BRAAFF) composed of 6 variables was associated with optimal area under curve and sensitivity for the diagnosis of AM. This method included 4 positive (blotches irregular, ridge pattern, asymmetry of structures and asymmetry of colours) and 2 negative predictors (furrow pattern and fibrillar pattern). CONCLUSION: The BRAAFF checklist significantly improves the diagnostic accuracy of dermoscopy for the diagnosis of AM. This article is protected by copyright. All rights reserved. |
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This article is protected by copyright. All rights reserved. |
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Publikations ID: 26211689 Quelle: öffnen |
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