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| Nature genetics. 2015 Jan 12. pii: ng.3185. doi: 10.1038/ng.3185. pmc: PMC4445140. mid: NIHMS647338 |
| Identification of six new susceptibility loci for invasive epithelial ovarian cancer. |
| Kuchenbaecker KB1, Ramus SJ2, Tyrer J3, Lee A4, Shen HC5, Beesley J6, Lawrenson K7, McGuffog L8, Healey S9, Lee JM10, Spindler TJ11, Lin YG12, Pejovic T13, Bean Y14, Li Q15, Coetzee S16, Hazelett D17, Miron A18, Southey M19, Terry MB20, Goldgar DE21, Buys SS22, Janavicius R23, Dorfling CM24, van Rensburg EJ25, Neuhausen SL26, Ding YC27, Hansen TV28, Jønson L29, Gerdes AM30, Ejlertsen B31, Barrowdale D32, Dennis J33, Benitez J34, Osorio A35, Garcia MJ36, Komenaka I37, Weitzel JN38, Ganschow P39, Peterlongo P40, Bernard L41, Viel A42, Bonanni B43, Peissel B44, Manoukian S45, Radice P46, Papi L47, Ottini L48, Fostira F49, Konstantopoulou I50, Garber J51, Frost D52, Perkins J53, Platte R54, Ellis S55, Godwin AK56, Schmutzler RK57, Meindl A58, Engel C59, Sutter C60, Sinilnikova OM61, Damiola F62, Mazoyer S63, Stoppa-Lyonnet D64, Claes K65, De Leeneer K66, Kirk J67, Rodriguez GC68, Piedmonte M69, O'Malley DM70, de la Hoya M71, Caldes T72, Aittomäki K73, Nevanlinna H74, Collée JM75, Rookus MA76, Oosterwijk JC77, Tihomirova L78, Tung N79, Hamann U80, Isaccs C81, Tischkowitz M82, Imyanitov EN83, Caligo MA84, Campbell IG85, Hogervorst FB86, Olah E87, Diez O88, Blanco I89, Brunet J90, Lazaro C91, Pujana MA92, Jakubowska A93, Gronwald J94, Lubinski J95, Sukiennicki G96, Barkardottir RB97, Plante M98, Simard J99, Soucy P100, Montagna M101, Tognazzo S102, Teixeira MR103, Pankratz VS104, Wang X105, Lindor N106, Szabo CI107, Kauff N108, Vijai J109, Aghajanian CA110, Pfeiler G111, Berger A112, Singer CF113, Tea MK114, Phelan CM115, Greene MH116, Mai PL117, Rennert G118, Mulligan AM119, Tchatchou S120, Andrulis IL121, Glendon G122, Toland AE123, Jensen UB124, Kruse TA125, Thomassen M126, Bojesen A127, Zidan J128, Friedman E129, Laitman Y130, Soller M131, Liljegren A132, Arver B133, Einbeigi Z134, Stenmark-Askmalm M135, Olopade OI136, Nussbaum RL137, Rebbeck TR138, Nathanson KL139, Domchek SM140, Lu KH141, Karlan BY142, Walsh C143, Lester J144, Hein A145, Ekici AB146, Beckmann MW147, Fasching PA148, Lambrechts D149, Van Nieuwenhuysen E150, Vergote I151, Lambrechts S152, Dicks E153, Doherty JA154, Wicklund KG155, Rossing MA156, Rudolph A157, Chang-Claude J158, Wang-Gohrke S159, Eilber U160, Moysich KB161, Odunsi K162, Sucheston L163, Lele S164, Wilkens LR165, Goodman MT166, Thompson PJ167, Shvetsov YB168, Runnebaum IB169, Dürst M170, Hillemanns P171, Dörk T172, Antonenkova N173, Bogdanova N174, Leminen A175, Pelttari LM176, Butzow R177, Modugno F178, Kelley JL179, Edwards RP180, Ness RB181, du Bois A182, Heitz F183, Schwaab I184, Harter P185, Matsuo K186, Hosono S187, Orsulic S188, Jensen A189, Kjaer SK190, Hogdall E191, Hasmad HN192, Azmi MA193, Teo SH194, Woo YL195, Fridley BL196, Goode EL197, Cunningham JM198, Vierkant RA199, Bruinsma F200, Giles GG201, Liang D202, Hildebrandt MA203, Wu X204, Levine DA205, Bisogna M206, Berchuck A207, Iversen ES208, Schildkraut JM209, Concannon P210, Weber RP211, Cramer DW212, Terry KL213, Poole EM214, Tworoger SS215, Bandera EV216, Orlow I217, Olson SH218, Krakstad C219, Salvesen HB220, Tangen IL221, Bjorge L222, van Altena AM223, Aben KK224, Kiemeney LA225, Massuger LF226, Kellar M227, Brooks-Wilson A228, Kelemen LE229, Cook LS230, Le ND231, Cybulski C232, Yang H233, Lissowska J234, Brinton LA235, Wentzensen N236, Hogdall C237, Lundvall L238, Nedergaard L239, Baker H240, Song H241, Eccles D242, McNeish I243, Paul J244, Carty K245, Siddiqui N246, Glasspool R247, Whittemore AS248, Rothstein JH249, McGuire V250, Sieh W251, Ji BT252, Zheng W253, Shu XO254, Gao YT255, Rosen B256, Risch HA257, McLaughlin JR258, Narod SA259, Monteiro AN260, Chen A261, Lin HY262, Permuth-Wey J263, Sellers TA264, Tsai YY265, Chen Z266, Ziogas A267, Anton-Culver H268, Gentry-Maharaj A269, Menon U270, Harrington P271, Lee AW272, Wu AH273, Pearce CL274, Coetzee G275, Pike MC276, Dansonka-Mieszkowska A277, Timorek A278, Rzepecka IK279, Kupryjanczyk J280, Freedman M281, Noushmehr H282, Easton DF283, Offit K284, Couch FJ285, Gayther S286, Pharoah PP287, Antoniou AC288, Chenevix-Trench G289 |
  Collaborators
Green AC Parsons PG Hayward NK Purdie DM Webb PM Whiteman DC Bowtell D Chenevix-Trench G Green A Webb P deFazio A Gertig D Hopper JL Miron A Goldgar DE John EM Terry MB Whittemore AS Buys SS Chung WK Daly MB Southey M Miron A John EM Hopper JL Southey M Whittemore AS Terry MB Chung WK Daly MB Goldgar DE Buys SS Janavicius R Rudaitis V Eglitis J Tihomirova L Nikitina-Zake L Tung N Dorfling CM van Rensburg EJ Steele L Neuhausen SL Ding YC Gerdes AM Ejlertsen B Nielsen FC Jønson L Andersen MK Hansen TV Lee A Antoniou AC Barrowdale D Dennis J Kuchenbaecker KB McGuffog L Healey S Easton DF Chenevix-Trench G Lee A Wang C Cunningham J Hart S Slager S Lasa A Osorio A Benitez J Godino J Tejada MI Garcia MJ Duran M Hall P Dicks E Fontaine A Komenaka I Weitzel JN Herzog J Ganschow P Peterlongo P Pilato B Lambo R Tommasi S Sardella D Capra F Ficarazzi F Mariette F Tizzoni L Bernard L Mariani P Volorio S Fortuzzi S Dall'Olio V Pensotti V Viel A Dolcetti R Bonanni B Feroce I Barile M Peissel B Zaffaroni D Cattaneo E Roversi G Melloni G Scuvera G Radice P Manoukian S Martayan A Savarese A Varesco L Gismondi V Putignano AL Papi L Genuardi M Tibiletti MG Ottini L Allavena A Pasini B Vignolo-Lutati F Vratimos A Fostira F Fountzilas G Konstantopoulou I Apostolou P Garber J Torres D Rashid MU Hamann U Donaldson A Murray A Dunning AM Chu C Brewer C Houghton C Jacobs C Oliver C Evans DG Frost D Eccles D Fineberg E Easton DF Frost D Ellis S Platte R Perkins J Miedzybrodzka Z Gregory H Morrison P Jeffers L Ong KR Hoffman J Donaldson A James M Paterson J Tischkowitz M Downing S Taylor A Murray A Rogers MT McCann E Kennedy MJ Barton D Porteous M Drummond S Brewer C Kivuva E Searle A Goodman S Hill K Davidson R Murday V Bradshaw N Snadden L Longmuir M Watt C Gibson S Haque E Tobias E Duncan A Izatt L Jacobs C Langman C Dorkins H Barwell J Adlard J Serra-Feliu G Ellis I Foo C Evans DG Lalloo F Taylor J Side L Male A Berlin C Eason J Collier R Henderson A Claber O Jobson I Walker L McLeod D Halliday D Durell S Stayner B Eeles R Rahman N Bancroft E Page E Ardern-Jones A Kohut K Wiggins J Pope J Saya S Taylor N Kemp Z Cook J Quarrell O Bardsley C Hodgson S Goff S Brice G Winchester L Eddy C Tripathi V Attard V Eccles D Lucassen A Crawford G McBride D Smalley S McCann E Douglas F Lalloo F ichert G Gregory H Dorkins H Cook J Eason J Perkins J Paterson J Adlard J Barwell J Ong KR Walker L Izatt L Side LE Kennedy MJ Cook M Rogers MT Porteous ME Harrington P Morrison PJ Platte R Eeles R Davidson R Hodgson S Ellis S Peock S Cole T Godwin AK Bove B Weaver J Sharma P Lee A Shapira I Vega A Becker A Meindl A Gehrig A Baumgärtner A Wappenschmidt B Weber BH Sutter C Engel C Niederacher D Schäfer D Steinemann D Gadzicki D Hahnen E Plendl H Deissler H Ruehl I Kast K Rhiem K Ditsch N Arnold N Varon-Mateeva R Schmutzler RK Preisler-Adams S Heidemann S Engert S Heinritz W Hardouin A Calender A de Pauw A Bressac-de Paillerets B Buecher B Delnatte C Tirapo C Verny-Pierre C Kientz C Nogues C Lasset C Houdayer C Muller D Leroux D Stoppa-Lyonnet D Rouleau E Lesueur F Prieur F Damiola F Sinilnikova O Mazoyer S Damiola F Barjhoux L Verny-Pierre C Giraud S Léone M Boutry-Kryza N Stoppa-Lyonnet D Gauthier-Villars M Buecher B Houdayer C Rouleau E Golmard L Collet A Moncoutier V Lefol C Belotti M de Pauw A Elan C Nogues C Fourme E Birot AM Bressac-de-Paillerets B Caron O Guillaud-Bataille M Bignon YJ Uhrhammer N Lasset C Bonadona V Handallou S Hardouin A Berthet P Vaur D Castera L Sobol H Bourdon V Noguchi T Remenieras A Eisinger F Coupier I Pujol P Peyrat JP Fournier J Révillion F Vennin P Adenis C Muller D Fricker JP Barouk-Simonet E Bonnet F Bubien V Sevenet N Longy M Toulas C Guimbaud R Gladieff L Feillel V Leroux D Dreyfus H Rebischung C Peysselon M Coron F Faivre L Prieur F Lebrun M Kientz C Ferrer SF Frénay M Vénat-Bouvet L Delnatte C Mortemousque I Coulet F Colas C Soubrier F Warcoin M Sokolowska J Bronner M Lynch HT Snyder CL Sobol H Dreyfus H Coupier I Peyrat JP Fricker JP Sokolowska J Barjhoux L Faivre L Venat-Bouvet L Castera L Akloul L Golmard L Frenay M Collonge-Rame MA Remon MA Lebrun M Fassy-Colcombet M Gauthier-Villars M Léoné M Longy M Belotti M Bronner M Boutry-Kryza N Uhrhammer N Sevenet N Sinilnikova OM Caron O Pujol P Berthet P Ferrer SF Giraud S Mazoyer S Bonadona V Caux-Moncoutier V Bignon YJ Isaacs C De Paepe A Poppe B Claes K De Leeneer K Cohn DE O'Malley DM Rodriguez GC Basil JB Hoffman JS Fiorica JV Hurteau JA Boggess JF Byron JW Carter J Kirk J Wakeley K Phillips KA Small L Andrews L DeMars LR Van Le L Piedmonte M Azodi M Friedlander M DiSilvestro PA Schwartz PE Salani R Nerenstone SR Blank SV Bae-Jump VL Romero A de la Hoya M Segura PP Caldes T Nevanlinna H Aittomäki K Khan S Muranen TA Jager A van der Hout AH van den Ouweland AM Hollestelle A Mensenkamp AR van Deurzen CH Kets CM Seynaeve C van Asperen CJ Aalfs CM Garcia EB van Leeuwen FE Hogervorst FB van der Baan FH Meijers-Heijboer HE Vasen HF Rookus MA Hogervorst FB van Leeuwen FE Verhoef S Schmidt MK Russell NS de Lange JL Wijnands R Collée JM van den Ouweland AM Hooning MJ Seynaeve C van Deurzen CH Obdeijn IM van Asperen CJ Wijnen JT Tollenaar RA Devilee P van Cronenburg TC Kets CM Mensenkamp AR Ausems MG van der Luijt RB van der Pol CC Aalfs CM van Os TA Gille JJ Waisfisz Q Meijers-Heijboer HE Gómez-Garcia EB Blok MJ Vasen HF Siesling S Verloop J Overbeek LI Kluijt I Collee J Gille JJ Knol-Bout JP Oosterwijk JC Wijnen JT van Roozendaal KE Schrijver LH Hooning MJ Tilanus-Linthorst MA Ausems MG Blom MJ van Dooren MF Blok MJ Ligtenberg MJ Rookus MA Kriege M Hoogerbrugge N Devilee P Waisfisz Q van der Luijt RB Verhoef S van Os TA Kwong A Ma E Chan TL Olah E Papp J Vaszko T Pocza T Balmana J Bosch N Diez O Teule A Izquierdo A Velasco A Solanes A Lazaro C Darder E Tornero E Capella G Blanco I Del Valle J Brunet J Feliubadalo L Navarro M Pujana MA Menendez M Salinas M Iglesias S Toloczko-Grabarek A Jakubowska A Gorski B Cybulski C Złowocka-Perłowska E Sukiennicki G Gronwald J Lubinski J Menkiszak J Durda K Jaworska-Bieniek K bniak TD Byrski T Huzarski T Arason A Agnarsson BA Johannsson OT Barkardottir RB Lesperance B Maugard C Chiquette J Plante M Dumont M Laframboise R Simard J Soucy P Casella C Alducci E D'Andrea E Montagna M Tognazzo S Agata S Peixoto A Teixeira MR Spurdle AB Holland H Beesley J Aghmesheh M Amor D Andrews L Antill Y Armitage S Arnold L Balleine R Bankier A Bastick P Beesley J Beilby J Bennett B Bennett I Berry G Blackburn A Bogwitz M Brennan M Brown M Buckley M Burgess M Burke J Butow P Byron K Callen D Campbell I Chauhan D Chauhan M Chenevix-Trench G Christian A Clarke C Colley A Cotton D Crook A Cui J Culling B Cummings M Dawson SJ deFazio A Delatycki M Dickson R Dixon J Dobrovic A Dudding T Edkins T Edwards S Eisenbruch M Farshid G Fawcett S Fellows A Fenton G Field M Firgaira F Flanagan J Fleming J Fong P Forbes J Fox S French J Friedlander M Gaff C Gardner M Gattas M George P Giles G Gill G Goldblatt J Greening S Grist S Haan E Hardie K Harris M Hart S Hayward N Healey S Heiniger L Hopper J Humphrey E Hunt C James P Jenkins M Jones A Kefford R Kidd A Kiely B Kirk J Koehler J Kollias J Kovalenko S Lakhani S Leaming A Leary J Lim J Lindeman G Lipton L Lobb L Mann G Marsh D McLachlan SA Meiser B Meldrum C Milne R Mitchell G Newman B Niedermayr E Nightingale S O'Connell S O'Loughlin I Osborne R Pachter N Patterson B Peters L Phillips K Price M Purser L Reeve T Reeve J Richards R Rickard E Rudzki BR Saleh M Salisbury E Sambrook J Saunders C Saunus J Sayer R Scott E Scott R Scott C Seshadri R Sexton A Sharma R Shelling A Simpson P Southey M Spurdle A Suthers G Sykes P Tassell M Taylor D Taylor J Thierry B Thomas S Thompson E Thorne H Townshend S Trainer A Tran L Tucker K Visvader JT Walker L Walpole I Ward R Waring P Warner B Warren G Williams R Wilson J Winship I Wu K Young MA Chen X Lee JW Lee MH Park SK Kim SW Friebel T Olswold C Stevens K Kosel M Lindor N Pankratz VS Wang X Fredericksen Z Couch FJ Tischkowitz M Foulkes WD Szabo CI Machackova E Foretova L Zikan M Pohlreich P Kleibl Z Catts ZA Dutra-Clarke A Aghajanian CA Przybylo J Vijai J Sarrel K Offit K Corines M Robson M Gaudet MM Kauff N Shah S Kirchhoff T Berger A Fink-Retter A Singer CF Rappaport C Kaulich DG Pfeiler G Tea MK Phelan CM Narod SA Greene MH Mai PL Savage SA Loud JT Sherman ME Lejbkowicz F Rennert G Sokolenko AP Imyanitov EN Selkirk C Hulick P Mulligan AM Glendon G Ozcelik H Andrulis IL Tchatchou S Toland AE Senter L Bojesen A Skytte AB Pedersen IS Sunde L Thomassen M Moeller ST Væth S Kruse TA Jensen UB Collavoli A Caligo MA Tancredi M Aretini P Teo SH Kaufman B Friedman E Zidan J Berger R Laitman Y Borg A Öfverholm A von Wachenfeldt A Liljegren A Lindblom A Melin B Arver B Ardnor CE Bustinza GB Olsson H Ehrencrona H Jernström H Rantala J Henriksson K Harbst K Nordling M Soller M Stenmark-Askmalm M Pigg MH Emanuelsson M Loman N Karlsson P Rosenquist R Liedgren S Kristoffersson U Einbeigi Z Huo D Sighoko D Zhang J Patrick-Miller L Verp M Olopade OI Nielsen S Zheng Y Seldon J Ganz PA Nussbaum RL Chan SB Moysich KB Odunsi K Sucheston L Pharoah PD Gayther SA Ramus SJ Nathanson KL Domchek SM Rebbeck TR Arun BK Lu KH Mitchell G Campbell I James P Karlan BY Walsh C Lester J Orsulic S Easton DF Frost D Ellis S Platte R Perkins J Miedzybrodzka Z Gregory H Morrison P Jeffers L Kai-ren Ong Hoffman J Donaldson A James M Paterson J Tischkowitz M Downing S Taylor A Murray A Rogers MT McCann E Kennedy M Barton D Porteous M Drummond S Brewer C Kivuva E Searle A Goodman S Hill K Davidson R Murday V Bradshaw N Snadden L Longmuir M Watt C Gibson S Haque E Tobias E Duncan A Izatt L Jacobs C Langman C Dorkins H Barwell J Adlard J Serra-Feliu G Ellis I Foo C Evans DG Lalloo F Taylor J Thames NE Side L Male A Berlin C Eason J Collier R Henderson A Claber O Jobson I Walker L McLeod D Halliday D Durell S Stayner B Eeles R Rahman N Bancroft E Page E Ardern-Jones A Kohut K Wiggins J Pope J Saya S Taylor N Kemp Z George A Cook J Quarrell O Bardsley C Hodgson S Goff S Brice G Winchester L Eddy C Tripathi V Attard V Eccles D Lucassen A Crawford G McBride D Smalley S Sinilnikova O Mazoyer S Damiola F Barjhoux L Verny-Pierre C Giraud S Léone M Boutry-Kryza N Stoppa-Lyonnet D Gauthier-Villars M Buecher B Houdayer C Rouleau E Golmard L Collet A Moncoutier V Lefol C Belotti M de Pauw A Elan C Nogues C Fourme E Birot AM Bressac-dePaillerets B Caron O Guillaud-Bataille M Bignon YJ Uhrhammer N Lasset C Bonadona V Handallou S Hardouin A Berthet P Vaur D Castera L Sobol H Bourdon V Noguchi T Remenieras A Eisinger F Coupier I Pujol P Fournier JP Révillion F Vennin P Adenis C Muller D Fricker JP Barouk-Simonet E Bonnet F Bubien V Sevenet N Longy M Toulas C Guimbaud R Gladieff L Feillel V Leroux D Dreyfus H Rebischung C Peysselon M Coron F Faivre L Prieur F Lebrun M Kientz C Ferrer SF Frénay M Vénat-Bouvet L Delnatte C Mortemousque I Coulet F Colas C Soubrier F Warcoin M Sokolowska J Bronner M Lynch HT Snyder CL Rookus MA Hogervorst FB van Leeuwen FE Verhoef S Schmidt MK Russell NS de Lange JL Wijnands R van den Ouweland AM Hooning MJ Seynaeve C van Deurzen CH Obdeijn IM van Asperen CJ Wijnen JT Tollenaar RA Devilee P van Cronenburg TC Kets CM Mensenkamp AR Ausems MG van der Luijt RB van der Pol CC Aalfs CM van Os TA Gille JJ Waisfisz Q Meijers-Heijboer HE Gómez-Garcia EB Blok MJ Oosterwijk JC van der Hout AH Mourits MJ de Bock GH Vasen HF Siesling S Verloop J Overbeek LI Aghmesheh M Amor D Andrews L Antill Y Armitage S Arnold L Balleine R Bankier A Bastick P Beesley J Beilby J Bennett B Bennett I Berry G Blackburn A Bogwitz M Brennan M Brown M Buckley M Burgess M Burke J Butow P Byron K Callen D Campbell I Chauhan D Chauhan M Chenevix-Trench G Christian A Clarke C Colley A Cotton D Crook A Cui J Culling B Cummings M Dawson SJ deFazio A Delatycki M Dickson R Dixon J Dobrovic A Dudding T Edkins T Edwards S Eisenbruch M Farshid G Fawcett S Fellows A Fenton G Field M Firgaira F Flanagan J Fleming J Fong P Forbes J Fox S French J Friedlander M Gaff C Gardner M Gattas M George P Giles G Gill G Goldblatt J Greening S Grist S Haan E Hardie K Harris M Hart S Hayward N Healey S Heiniger L Hopper J Humphrey E Hunt C James P Jenkins M Jones A Kefford R Kidd A Kiely B Kirk J Koehler J Kollias J Kovalenko S Lakhani S Leaming A Leary J Lim J Lindeman G Lipton L Lobb L Mann G Marsh D McLachlan SA Meiser B Meldrum C Milne R Mitchell G Newman B Niedermayr E Nightingale S O'Connell S O'Loughlin I Osborne R Pachter N Patterson B Peters L Phillips K Price M Purser L Reeve T Reeve J Richards R Rickard E Robinson B Rudzki B Saleh M Salisbury E Sambrook J Saunders C Saunus J Sayer R Scott E Scott R Scott C Seshadri R Sexton A Sharma R Shelling A Simpson P Southey M Spurdle A Suthers G Sykes P Tassell M Taylor D Taylor J Thierry B Thomas S Thompson E Thorne H Townshend S Trainer A Tran L Tucker K Tyler J Visvader J Walker L Walpole I Ward R Waring P Warner B Warren G Williams R Wilson J Winship I Wu K Young MA
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Author information
1Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
2Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 3Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. 4Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 5Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 6Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 7Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 8Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 9Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 10Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 11Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 12Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, California, USA. 131] Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA. [2] Knight Cancer Institute, Portland, Oregon, USA. 141] Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA. [2] Knight Cancer Institute, Portland, Oregon, USA. 15Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. 161] Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. [2] Center for Cell-Based Therapy, Monte Alegre, Ribeirão Preto, Brazil. [3] Center for Integrative Systems Biology, Monte Alegre, Ribeirão Preto, Brazil. 171] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Urology, University of Southern California, Los Angeles, California, USA. 18Department of Genomics and Genome Sciences, Case Western Reserve University Medical School, Cleveland, Ohio, USA. 19Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia. 20Department of Epidemiology, Columbia University, New York, New York, USA. 21Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA. 22Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA. 231] Department of Molecular and Regenerative Medicine, Hematology, Oncology and Transfusion Medical Center, Vilinius University Hospital Santariskiu Clinics, Vilnius, Lithuania, Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania. [2] State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. 24Department of Genetics, University of Pretoria, Pretoria, South Africa. 25Department of Genetics, University of Pretoria, Pretoria, South Africa. 26Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA. 27Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, California, USA. 28Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 29Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 30Department of Clinical Genetics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 31Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. 32Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 331] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. [2] Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. 341] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Human Genotyping Unit (CEGEN), Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [3] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 351] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 361] Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Centre (CNIO), Madrid, Spain. [2] Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. 37Maricopa Medical Center, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA. 38Clinical Cancer Genetics, for the City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA. 39Cook County Health and Hospital System, care of City of Hope Clinical Cancer Genetics Community Research Network, Duarte, California, USA. 40Fondazione Istituto FIRC (Italian Foundation for Cancer Research) di Oncologia Molecolare (IFOM), Milan, Italy. 411] Department of Experimental Oncology, Istituto Europeo di Oncologia, Milan, Italy. [2] Cogentech Cancer Genetic Test Laboratory, Milan, Italy. 42Division of Experimental Oncology, CRO (Centro di Riferimento Oncologico) Aviano National Cancer Institute, Aviano, Italy. 43Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia, Milan, Italy. 44Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico (Italian Research Hospital)) Istituto Nazionale Tumori (INT), Milan, Italy. 45Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico (Italian Research Hospital)) Istituto Nazionale Tumori (INT), Milan, Italy. 46Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale Tumori (INT), Milan, Italy. 47Unit of Medical Genetics, Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy. 48Department of Molecular Medicine, University La Sapienza, Rome, Italy. 49Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece. 50Molecular Diagnostics Laboratory, INRASTES (Institute of Nuclear and Radiological Sciences and Technology), National Centre for Scientific Research 'Demokritos', Aghia Paraskevi Attikis, Athens, Greece. 51Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. 52Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 53Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 54Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 55Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 56Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA. 571] Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany. [2] Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany. [3] Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany. [4] On behalf of the German Consortium of Hereditary Breast and Ovarian Cancer (GC-HBOC). 58Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany. 59Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. 60Institute of Human Genetics, University Heidelberg, Heidelberg, Germany. 611] INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France. [2] Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon-Centre Léon Bérard, Lyon, France. 62INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France. 63INSERM U1052, CNRS UMR 5286, Université Lyon, Centre de Recherche en Cancérologie de Lyon, Lyon, France. 641] Institut Curie, Department of Tumour Biology, Paris, France. [2] Institut Curie, INSERM U830, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. 65Center for Medical Genetics, Ghent University, Ghent, Belgium. 66Center for Medical Genetics, Ghent University, Ghent, Belgium. 67Australia New Zealand Gynecologic Oncology Group (ANZGOG) and Familial Cancer Service, Westmead Hosptial, Sydney, New South Wales, Australia. 68Division of Gynecologic Oncology, NorthShore University HealthSystem, Evanston, Illinois, USA. 69Gynecologic Oncology Group, Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, New York, USA. 70James Cancer Center, Ohio State University, Columbus, Ohio, USA. 71Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain. 72Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Madrid, Spain. 73Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland. 74Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. 75Department of Clinical Genetics, Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, the Netherlands. 76Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands. 77Department of Genetics, University Medical Center, Groningen University, Groningen, the Netherlands. 78Latvian Biomedical Research and Study Centre, Riga, Latvia. 79Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA. 80Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany. 81Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 82Program in Cancer Genetics, McGill University, Montreal, Quebec, Canada. 83N.N. Petrov Institute of Oncology, St. Petersburg, Russia. 84Section of Genetic Oncology, Department of Laboratory Medicine, University of Pisa and University Hospital of Pisa, Pisa, Italy. 85VBCRC (Victorian Breast Cancer Research Consortium) Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. 86Family Cancer Clinic, Netherlands Cancer Institute, Amsterdam, the Netherlands. 87Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary. 88Oncogenetics Group, University Hospital Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO) and Universitat Autònoma de Barcelona, Barcelona, Spain. 89Genetic Counseling Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute)-Catalan Institute of Oncology, Barcelona, Spain. 90Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona)-Catalan Institute of Oncology, Girona, Spain. 91Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain. 92Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL-Catalan Institute of Oncology, Barcelona, Spain. 93Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 94Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 95Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 96Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland. 97Department of Pathology, Landspitali University Hospital and Biomedical Centre (BMC), Faculty of Medicine, University of Iceland, Reykjavik, Iceland. 98Gynaecologic Oncology Service, Centre Hospitalier Universitaire de Québec (CHUQ), Quebec City, Quebec, Canada. 99Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, Laval University, Quebec City, Quebec, Canada. 100Centre Hospitalier Universitaire de Québec (CHUQ) Research Center, Laval University, Quebec City, Quebec, Canada. 101Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV)-IRCCS, Padua, Italy. 102Immunology and Molecular Oncology Unit, Istituto Oncologico Veneto (IOV)-IRCCS, Padua, Italy. 1031] Biomedical Sciences Institute (ICBAS), Porto University, Porto, Portugal. [2] Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. 104Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. 105Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. 106Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. 107National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA. 108Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 109Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 110Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 111Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 112Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 113Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 114Department of Obstetrics and Gynecology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria. 115Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. 116Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA. 117Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Rockville, Maryland, USA. 118Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel. 1191] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [2] Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada. 120Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 1211] Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. [2] Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada. 122Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Ontario, Canada. 123Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio, USA. 124Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark. 125Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. 126Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. 127Department of Clinical Genetics, Vejle Hospital, Vejle, Denmark. 128Institute of Oncology, Rivka Ziv Medical Center, Zefat, Israel. 129Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel. 130Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Aviv, Israel. 131Department of Clinical Genetics, Lund University Hospital, Lund, Sweden. 132Department of Oncology, Karolinska University Hospital, Stockholm, Sweden. 133Department of Oncology, Karolinska University Hospital, Stockholm, Sweden. 134Department of Oncology, Sahlgrenska University Hospital, Gothenburg, Sweden. 135Division of Clinical Genetics, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. 136Center for Clinical Cancer Genetics and Global Health, University of Chicago Medical Center, Chicago, Illinois, USA. 137Department of Medicine and Genetics, University of California, San Francisco, San Francisco, California, USA. 138Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 139Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 140Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. 141Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 142Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 143Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 144Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 145Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany. 146Institute of Human Genetics, University of Erlangen-Nuremberg, Erlangen, Germany. 147Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany. 1481] Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany. [2] Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. 1491] Vesalius Research Center, VIB, Leuven, Belgium. [2] Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium. 150Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium. 151Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium. 152Division of Gynecological Oncology, Department of Oncology, University Hospitals Leuven, Leuven, Belgium. 153Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. 154Department of Community and Family Medicine, Section of Biostatistics and Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire, USA. 155Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. 1561] Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. [2] Department of Epidemiology, University of Washington, Seattle, Washington, USA. 157Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 158Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 159Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany. 160Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 161Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA. 162Department of Gynecologic Oncology, Roswell Park Cancer Institute, Buffalo, New York, USA. 163Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA. 164Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York, USA. 165Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA. 1661] Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. [2] Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA. 1671] Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. [2] Community and Population Health Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA. 168Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, USA. 169Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany. 170Department of Gynecology, Jena University Hospital-Friedrich Schiller University, Jena, Germany. 171Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany. 172Gynaecology Research Unit, Hannover Medical School, Hannover, Germany. 173Byelorussian Institute for Oncology and Medical Radiology Aleksandrov N.N., Minsk, Belarus. 174Gynaecology Research Unit, Hannover Medical School, Hannover, Germany. 175Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. 176Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. 1771] Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. [2] Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland. 1781] Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [2] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. [3] Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [4] Women's Cancer Research Program, Magee-Women's Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA. 179Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. 1801] Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. [2] Ovarian Cancer Center of Excellence, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 181University of Texas School of Public Health, Houston, Texas, USA. 1821] Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany. [2] Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. 1831] Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany. [2] Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. 184Institut für Humangenetik Wiesbaden, Wiesbaden, Germany. 1851] Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany. [2] Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Essen, Germany. 186Department of Preventive Medicine, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan. 187Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan. 188Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. 189Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. 1901] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. [2] Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 1911] Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. [2] Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark. 192Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. 193Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. 1941] Cancer Research Initiatives Foundation, Sime Darby Medical Centre, Subang Jaya, Malaysia. [2] University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. 1951] Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. [2] University Malaya Cancer Research Institute, Faculty of Medicine, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia. 196Biostatistics and Informatics Shared Resource, University of Kansas Medical Center, Kansas City, Kansas, USA. 197Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. 198Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. 199Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA. 200Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. 201Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia. 202College of Pharmacy and Health Sciences, Texas Southern University, Houston, Texas, USA. 203Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 204Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA. 205Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 206Gynecology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 207Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina, USA. 208Department of Statistical Science, Duke University, Durham, North Carolina, USA. 2091] Cancer Control and Population Sciences, Duke Cancer Institute, Durham, North Carolina, USA. [2] Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA. 2101] Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA. [2] Genetics Institute, University of Florida, Gainesville, Florida, USA. 211Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina, USA. 2121] Harvard School of Public Health, Boston, Massachusetts, USA. [2] Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. 2131] Harvard School of Public Health, Boston, Massachusetts, USA. [2] Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. 2141] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. 2151] Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. 216Cancer Prevention and Control, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA. 217Department of Epidemiology and Biostatistics, Epidemiology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 218Department of Epidemiology and Biostatistics, Epidemiology Service, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 2191] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. 2201] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. 2211] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. 2221] Centre for Cancer Biomarkers, Department of Clinical Medicine, University of Bergen, Bergen, Norway. [2] Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway. 223Department of Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands. 2241] Comprehensive Cancer Center The Netherlands, Utrecht, the Netherlands. [2] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. 2251] Department for Health Evidence, Radboud University Medical Centre, Nijmegen, the Netherlands. [2] Department of Urology, Radboud University Medical Centre, Nijmegen, the Netherlands. 226Department of Gynaecology, Radboud University Medical Centre, Nijmegen, the Netherlands. 2271] Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, USA. [2] Knight Cancer Institute, Portland, Oregon, USA. 2281] Canada's Michael Smith Genome Sciences Centre, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. [2] Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada. 229Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. 230Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, New Mexico, USA. 231Cancer Control Research, British Columbia Cancer Agency, Vancouver, British Columbia, Canada. 232International Hereditary Cancer Center, Department of Genetics and Pathology, Clinic of Opthalmology, Pomeranian Medical University, Szczecin, Poland. 233Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. 234Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. 235Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. 236Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. 237Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 238Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 239Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. 240Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. 241Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. 242Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK. 243Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, UK. 244Cancer Research UK Clinical Trials Unit, Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK. 245Cancer Research UK Clinical Trials Unit, Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK. 246Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, UK. 247Cancer Research UK Clinical Trials Unit, Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK. 248Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA. 249Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA. 250Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA. 251Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, California, USA. 252Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA. 253Vanderbilt University School of Medicine, Nashville, Tennessee, USA. 254Vanderbilt University School of Medicine, Nashville, Tennessee, USA. 255Shanghai Cancer Institute, Shanghai, China. 2561] Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. [2] Department of Gynecologic-Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada. 257Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. 258Prosserman Centre for Health Research, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. 259Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada. 260Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. 261Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida, USA. 262Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida, USA. 263Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. 264Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. 265Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, USA. 266Department of Biostatistics, Moffitt Cancer Center, Tampa, Florida, USA. 267Department of Epidemiology, University of California-Irvine, Irvine, California, USA. 268Department of Epidemiology, University of California-Irvine, Irvine, California, USA. 269Women's Cancer, University College London Elizabeth Garrett Anderson (EGA) Institute for Women's Health, London, UK. 270Women's Cancer, University College London Elizabeth Garrett Anderson (EGA) Institute for Women's Health, London, UK. 271Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. 272Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 273Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 274Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 2751] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Urology, University of Southern California, Los Angeles, California, USA. 2761] Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. [2] Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 277Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. 278Department of Obstetrics, Gynecology and Oncology, 2nd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland. 279Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. 280Department of Pathology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. 281Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA. 282Department of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil. 283Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 284Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA. 2851] Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA. [2] Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. 286Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California, USA. 287Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK. 288Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. 289Cancer Division, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
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Abstract Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high risk of EOC. After imputation to 1000 Genomes Project data, we assessed associations of 11 million genetic variants with EOC risk from 15,437 cases unselected for family history and 30,845 controls and from 15,252 BRCA1 mutation carriers and 8,211 BRCA2 mutation carriers (3,096 with ovarian cancer), and we combined the results in a meta-analysis. This new study design yielded increased statistical power, leading to the discovery of six new EOC susceptibility loci. Variants at 1p36 (nearest gene, WNT4), 4q26 (SYNPO2), 9q34.2 (ABO) and 17q11.2 (ATAD5) were associated with EOC risk, and at 1p34.3 (RSPO1) and 6p22.1 (GPX6) variants were specifically associated with the serous EOC subtype, all with P < 5 × 10(-8). Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers. |
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Publikations ID: 25581431 Quelle: öffnen |
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