Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2014 Dec 18. pii: S1083-8791(14)01378-0. doi: 10.1016/j.bbmt.2014.12.001. pmc: PMC4329079. mid: NIHMS650779 |
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report. |
Jagasia MH1, Greinix HT2, Arora M3, Williams KM4, Wolff D5, Cowen EW6, Palmer J7, Weisdorf D8, Treister NS9, Cheng GS10, Kerr H11, Stratton P12, Duarte RF13, McDonald GB14, Inamoto Y15, Vigorito A16, Arai S17, Datiles MB18, Jacobsohn D19, Heller T20, Kitko CL21, Mitchell SA22, Martin PJ23, Shulman H24, Wu RS25, Cutler CS26, Vogelsang GB27, Lee SJ28, Pavletic SZ29, Flowers ME30 |
Abstract The 2005 National Institutes of Health (NIH) Consensus Conference proposed new criteria for diagnosing and scoring the severity of chronic graft-versus-host disease (GVHD). The 2014 NIH consensus maintains the framework of the prior consensus with further refinement based on new evidence. Revisions have been made to address areas of controversy or confusion, such as the overlap chronic GVHD subcategory and the distinction between active disease and past tissue damage. Diagnostic criteria for involvement of mouth, eyes, genitalia, and lungs have been revised. Categories of chronic GVHD should be defined in ways that indicate prognosis, guide treatment, and define eligibility for clinical trials. Revisions have been made to focus attention on the causes of organ-specific abnormalities. Attribution of organ-specific abnormalities to chronic GVHD has been addressed. This paradigm shift provides greater specificity and more accurately measures the global burden of disease attributed to GVHD, and it will facilitate biomarker association studies. |
Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved. |
KEYWORDS: Chronic graft-versus-host disease, Diagnosis, National Institutes of Health, Staging |
Publikations ID: 25529383 Quelle: öffnen |